Protein: FNDC5
Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) [Cleaved into: Irisin]

Gene: FNDC5
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q8NAU1

Gene Ontology (top 5):
GO:0005179 - hormone activity
GO:0005576 - extracellular region
GO:0005778 - peroxisomal membrane
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369368

A1AT
Alpha-1-antitrypsin

1

5

High-throughput

0.691

High

379018

PIGR
Polymeric immunoglobulin receptor

1

2

High-throughput

0.691

High

387990

FIBG
Fibrinogen gamma chain

1

1

High-throughput

0.691

High

424527

PAI2
Plasminogen activator inhibitor 2

1

6

High-throughput

0.691

High

445634

CEAM5
Cell adhesion molecule CEACAM5

1

3

High-throughput

0.691

High

568259

PLST
Plastin-3

1

2

High-throughput

0.691

High

631349

RAB5A
Ras-related protein Rab-5A

1

7

High-throughput

0.691

High

671826

ZA2G
Zinc-alpha-2-glycoprotein

1

2

High-throughput

0.691

High

713416

SPB3
Serpin B3

1

6

High-throughput

0.691

High

874823

SPB4
Serpin B4

1

6

High-throughput

0.691

High

956594

RAB5B
Ras-related protein Rab-5B

1

7

High-throughput

0.691

High

963206

LYSC
Lysozyme C

1

1

High-throughput

0.691

High

1009682

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.691

High

1022551

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

4

High-throughput

0.691

High

1332797

SPB12
Serpin B12

1

7

High-throughput

0.691

High

1108491

TRPC3
Short transient receptor potential channel 3

1

0

Small-scale

0.687

High

389664

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.656

High

322042

ENDD1
Endonuclease domain-containing 1 protein

2

1

High-throughput

0.628

High

624651

SL9A1
Sodium/hydrogen exchanger 1

2

2

High-throughput

0.628

High

799630

GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha

2

2

High-throughput

0.628

High

1332794

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

2

2

High-throughput

0.628

High

86008

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

5

High-throughput

0.618

High

895457

SPB8
Serpin B8

1

6

High-throughput

0.618

High

1332813

SPB13
Serpin B13

1

6

High-throughput

0.618

High

389631

AMBP
Protein AMBP

1

1

Small-scale

0.618

High

1332800

SLK
STE20-like serine/threonine-protein kinase

1

0

High-throughput

0.578

High

379118

IGKC
Immunoglobulin kappa constant

1

6

High-throughput

0.575

High

379280

IGHG1
Immunoglobulin heavy constant gamma 1

1

6

High-throughput

0.575

High

379376

IGHG2
Immunoglobulin heavy constant gamma 2

1

6

High-throughput

0.575

High

379551

IGHM
Immunoglobulin heavy constant mu

1

5

High-throughput

0.575

High

379678

IGHA1
Immunoglobulin heavy constant alpha 1

1

5

High-throughput

0.575

High

379757

IGHA2
Immunoglobulin heavy constant alpha 2

1

6

High-throughput

0.575

High

1332816

RHBD3
Rhomboid domain-containing protein 3

2

1

High-throughput

0.574

High

262543

MCE1
mRNA-capping enzyme

1

1

High-throughput

0.553

High

133189

QSOX1
Sulfhydryl oxidase 1

1

7

High-throughput

0.536

High

210766

KLK10
Kallikrein-10

1

8

High-throughput

0.536

High

238671

AK1BA
Aldo-keto reductase family 1 member B10

1

1

High-throughput

0.536

High

239282

TM11D
Transmembrane protease serine 11D

1

5

High-throughput

0.536

High

248740

PEPL
Periplakin

1

4

High-throughput

0.536

High

353447

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.536

High

366189

HPT
Haptoglobin

1

7

High-throughput

0.536

High

369892

CO3
Complement C3

1

3

High-throughput

0.536

High

424226

S10A8
Protein S100-A8

1

7

High-throughput

0.536

High

445030

S10A9
Protein S100-A9

1

7

High-throughput

0.536

High

464462

TSP1
Thrombospondin-1

1

5

High-throughput

0.536

High

568967

ANXA8
Annexin A8

1

1

High-throughput

0.536

High

636177

ENDOU
Uridylate-specific endoribonuclease

1

1

High-throughput

0.536

High

652361

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

4

High-throughput

0.536

High

693030

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.536

High

722799

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

4

High-throughput

0.536

High

748653

DSG3
Desmoglein-3

1

3

High-throughput

0.536

High

1009856

NUCB2
Nucleobindin-2

1

2

High-throughput

0.536

High

1037013

DSC2
Desmocollin-2

1

2

High-throughput

0.536

High

1058529

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.536

High

1061260

RHG01
Rho GTPase-activating protein 1

1

1

High-throughput

0.536

High

1117966

PKP1
Plakophilin-1

1

2

High-throughput

0.536

High

1160919

PRSS8
Prostasin

1

5

High-throughput

0.536

High

1251082

RPTN
Repetin

1

6

High-throughput

0.536

High

1326483

BPIB2
BPI fold-containing family B member 2

1

1

High-throughput

0.536

High

1332788

MUC7
Mucin-7

1

1

High-throughput

0.536

High

1332789

BPIB1
BPI fold-containing family B member 1

1

2

High-throughput

0.536

High

1332790

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

1

High-throughput

0.536

High

1332796

CPNS2
Calpain small subunit 2

1

2

High-throughput

0.536

High

1332798

NIBA2
Protein Niban 2

1

1

High-throughput

0.536

High

1332802

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

1

High-throughput

0.536

High

1332803

MUC5B
Mucin-5B

1

4

High-throughput

0.536

High

1332804

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.536

High

1332807

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.536

High

1332808

KLK14
Kallikrein-14

1

7

High-throughput

0.536

High

1332812

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

5

High-throughput

0.536

High

1332814

KLK13
Kallikrein-13

1

7

High-throughput

0.536

High

1332817

PKP3
Plakophilin-3

1

2

High-throughput

0.536

High

856809

BAG6
Large proline-rich protein BAG6

1

3

High-throughput

0.514

High

126244

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

143966

EST2
Cocaine esterase

1

0

High-throughput

0.513

High

348877

CLIC3
Chloride intracellular channel protein 3

1

0

High-throughput

0.513

High

358062

ADH1G
Alcohol dehydrogenase 1C

1

0

High-throughput

0.513

High

378702

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.513

High

387295

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

391053

TRFL
Lactotransferrin

1

0

High-throughput

0.513

High

391743

STAT
Statherin

1

0

High-throughput

0.513

High

471552

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

505869

PA24B
Cytosolic phospholipase A2 beta

1

0

High-throughput

0.513

High

553015

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

615220

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.513

High

627892

TCO1
Transcobalamin-1

1

0

High-throughput

0.513

High

1332792

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.513

High

1332795

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

183354

ZN185
Zinc finger protein 185

1

1

High-throughput

0.489

High

276608

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.489

High

277749

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.489

High

328444

SCEL
Sciellin

1

1

High-throughput

0.489

High

358889

AL1A1
Aldehyde dehydrogenase 1A1

1

2

High-throughput

0.489

High

457887

INVO
Involucrin

1

4

High-throughput

0.489

High

592864

CBR1
Carbonyl reductase [NADPH] 1

1

1

High-throughput

0.489

High

635616

FILA
Filaggrin

1

8

High-throughput

0.489

High

706220

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

868738

LEG7
Galectin-7

1

1

High-throughput

0.489

High

877355

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.489

High

1048470

AK1C1
Aldo-keto reductase family 1 member C1

1

1

High-throughput

0.489

High

1062264

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

4

High-throughput

0.489

High

1120927

TRI29
Tripartite motif-containing protein 29

1

1

High-throughput

0.489

High

1248706

SBSN
Suprabasin

1

1

High-throughput

0.489

High

1252730

GBP6
Guanylate-binding protein 6

1

3

High-throughput

0.489

High

1332787

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

3

High-throughput

0.489

High

1332793

EVPL
Envoplakin

1

4

High-throughput

0.489

High

1332801

GHITM
Growth hormone-inducible transmembrane protein

1

2

High-throughput

0.489

High

1332809

SPRR3
Small proline-rich protein 3

1

1

High-throughput

0.489

High

1332810

CRNN
Cornulin

1

7

High-throughput

0.489

High

820567

GPV
Platelet glycoprotein V

1

2

Small-scale

0.479

High

1136820

MO4L2
Mortality factor 4-like protein 2

1

1

Small-scale

0.479

High

1332799

PD1L2
Programmed cell death 1 ligand 2

1

4

Small-scale

0.479

High

1022242

MUC5A
Mucin-5AC

1

3

High-throughput

0.445

High

75697

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

3

High-throughput

0.437

High

566185

K1C10
Keratin, type I cytoskeletal 10

1

1

Small-scale

0.437

High

1332811

MO4L1
Mortality factor 4-like protein 1

1

1

Small-scale

0.437

High

69523

A2ML1
Alpha-2-macroglobulin-like protein 1

1

3

High-throughput

0.407

High

517247

AMY1B
Alpha-amylase 1B

1

1

High-throughput

0.407

High

294790

CAN15
Calpain-15

2

0

High-throughput

0.328

High

1248485

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.328

High

692752

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

933031

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.279

Low

1036580

SEMG2
Semenogelin-2

1

0

High-throughput

0.279

Low

1162837

H2A2C
Histone H2A type 2-C

1

0

High-throughput

0.279

Low

1163931

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.279

Low

1200351

APRV1
Retroviral-like aspartic protease 1

1

0

High-throughput

0.279

Low

1207921

SAMD9
Sterile alpha motif domain-containing protein 9

1

0

High-throughput

0.279

Low

1218600

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.279

Low

1242797

LEG1H
Protein LEG1 homolog

1

0

High-throughput

0.279

Low

1256960

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

1332791

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

1332806

GLTP
Glycolipid transfer protein

1

0

High-throughput

0.279

Low

1332815

NDRG2
Protein NDRG2

1

0

High-throughput

0.279

Low

772031

K1C9
Keratin, type I cytoskeletal 9

1

0

Small-scale

0.249

Low

777520

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

Small-scale

0.249

Low

1295067

F90A1
Protein FAM90A1

1

0

Small-scale

0.249

Low

1332805

RASF1
Ras association domain-containing protein 1

1

0

Small-scale

0.249

Low

1272398

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025