HitPredict

Interactor 1: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Interactor 2: EVL (Q9UI08)
Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)
Gene: EVL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.705

Property	Details
Experiments	29892012, 25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane GO:0017124 - SH3 domain binding GO:0030027 - lamellipodium GO:1900028 - negative regulation of ruffle assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 366 Hs			1 416
+	Hs
		840593 ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Hs
		1205736 ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00		HOME1_HUMAN (1-188): 3e-55: 188: 19.90
+	Hs
		1345493 ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00		HOME2_HUMAN (1-164): 3.47e-53: 182: 20.36
+	Hs
		1345512 ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00		HOME3_HUMAN (3-169): 1.07e-37: 141: 20.00
+	Hs
		1237895 ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00		ENAH_HUMAN (94-415): 1.88e-29: 122: 32.24
+	Hs
		282318 NEBL_HUMAN (13-363): 2.92e-35: 139: 14.13		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Hs
		282344 NEBL_HUMAN (13-363): 2.92e-35: 139: 14.13		SPRE1_HUMAN (2-165): 1.31e-48: 173: 26.74
+	Hs
		840586 ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Hs
		840522 ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Hs
		1205704 ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49		HOME1_HUMAN (1-188): 3e-55: 188: 19.90
+	Hs
		282372 NEBL_HUMAN (13-363): 2.92e-35: 139: 14.13		HOME3_HUMAN (3-169): 1.07e-37: 141: 20.00
+	Hs
		1345510 ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18		HOME3_HUMAN (3-169): 1.07e-37: 141: 20.00
+	Hs
		1237890 ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18		ENAH_HUMAN (94-415): 1.88e-29: 122: 32.24
+	Hs
		203262 PACN2_HUMAN (17-363): 1.11e-44: 162: 14.29		SYNJ1_HUMAN (94-376): 2.64e-09: 61.6: 8.78
+	Hs
		203224 MYO1E_HUMAN (34-363): 1.97e-42: 159: 18.34		SYNJ1_HUMAN (94-376): 2.64e-09: 61.6: 8.78
+	Hs
		1052365 SRC8_HUMAN (40-363): 2.07e-42: 157: 16.12		CABIN_HUMAN (186-393): 8.37e-09: 60: 13.84
+	Hs
		203251 PACN1_HUMAN (11-363): 5.47e-37: 140: 12.67		SYNJ1_HUMAN (94-376): 2.64e-09: 61.6: 8.78
+	Mm
		88459 SH3G2_MOUSE (265-363): 3.47e-27: 111: 24.75		D3Z656_MOUSE (82-402): 8.37e-11: 66.2: 12.01
+	Hs
		203249 SH3G2_HUMAN (265-363): 7.89e-26: 108: 23.76		SYNJ1_HUMAN (94-376): 2.64e-09: 61.6: 8.78
+	Rn
		192354 SH3G2_RAT (265-363): 2.5e-26: 109: 23.76		SYNJ1_RAT (89-371): 5.6e-09: 60.4: 13.95