Protein: HSPB8
Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22)

Gene: HSPB8
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q9UJY1

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0034620 - cellular response to unfolded protein

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458895

HSPB7
Heat shock protein beta-7

5

18

Small-scale

0.941

High

415924

HSPB1
Heat shock protein beta-1

3

16

Small-scale

0.839

High

1460788

HSPB8
Heat shock protein beta-8

2

19

Small-scale

0.825

High

1156344

HSPB2
Heat shock protein beta-2

2

16

Small-scale

0.817

High

347987

BAG3
BAG family molecular chaperone regulator 3

13

9

Small-scale

0.762

High

156395

HSPB6
Heat shock protein beta-6

1

15

Small-scale

0.713

High

384745

CRYAB
Alpha-crystallin B chain

1

15

Small-scale

0.713

High

1180199

QRIC1
Transcriptional regulator QRICH1

4

8

High-throughput

0.704

High

61677

VWA8
von Willebrand factor A domain-containing protein 8

3

1

High-throughput

0.675

High

904409

BRCA2
Breast cancer type 2 susceptibility protein

3

1

High-throughput

0.675

High

1410809

NUD12
NAD-capped RNA hydrolase NUDT12

3

6

High-throughput

0.675

High

1153610

MLF2
Myeloid leukemia factor 2

3

3

High-throughput

0.669

High

1361875

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

3

6

High-throughput

0.667

High

1092307

HSPB3
Heat shock protein beta-3

1

17

Small-scale

0.656

High

651109

RFX1
MHC class II regulatory factor RFX1

2

3

High-throughput

0.628

High

1051886

EF1A2
Elongation factor 1-alpha 2

2

1

High-throughput

0.628

High

1168956

LONF2
LON peptidase N-terminal domain and RING finger protein 2

2

7

High-throughput

0.628

High

1253950

FA83H
Protein FAM83H

2

3

High-throughput

0.628

High

1257839

ACD11
Acyl-CoA dehydrogenase family member 11

2

2

High-throughput

0.628

High

1349274

WDR20
WD repeat-containing protein 20

2

6

High-throughput

0.628

High

1350201

ALMS1
Centrosome-associated protein ALMS1

2

6

High-throughput

0.628

High

1419384

SETD2
Histone-lysine N-methyltransferase SETD2

2

2

High-throughput

0.628

High

155183

SOCS7
Suppressor of cytokine signaling 7

2

2

High-throughput

0.606

High

296008

TPC6A
Trafficking protein particle complex subunit 6A

2

2

High-throughput

0.606

High

1135237

Q149M6
Exophilin 5

3

1

High-throughput

0.585

High

880479

RPIA
Ribose-5-phosphate isomerase

2

0

High-throughput

0.580

High

1272361

ATOSB
Atos homolog protein B

2

0

High-throughput

0.580

High

1460792

DUS12
Dual specificity protein phosphatase 12

1

6

High-throughput

0.573

High

1337870

EXPH5
Exophilin-5

3

1

High-throughput

0.558

High

1309182

MISP
Mitotic interactor and substrate of PLK1

2

1

High-throughput

0.553

High

156370

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

3

High-throughput

0.536

High

159024

ZN195
Zinc finger protein 195

1

2

High-throughput

0.536

High

161650

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

2

High-throughput

0.536

High

1438750

ZBT20
Zinc finger and BTB domain-containing protein 20

1

4

High-throughput

0.536

High

1439436

SYF1
Pre-mRNA-splicing factor SYF1

1

5

High-throughput

0.536

High

161758

APAF
Apoptotic protease-activating factor 1

1

4

High-throughput

0.536

High

174142

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.536

High

174276

ARHGA
Rho guanine nucleotide exchange factor 10

1

3

High-throughput

0.536

High

175256

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.536

High

186816

P73
Tumor protein p73

1

5

High-throughput

0.536

High

273592

DJC13
DnaJ homolog subfamily C member 13

1

2

High-throughput

0.536

High

275924

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

1

High-throughput

0.536

High

302993

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

4

High-throughput

0.536

High

321061

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.536

High

446190

PYGL
Glycogen phosphorylase, liver form

1

2

High-throughput

0.536

High

447890

TPM3
Tropomyosin alpha-3 chain

1

6

High-throughput

0.536

High

464226

TPM2
Tropomyosin beta chain

1

6

High-throughput

0.536

High

482978

TPM1
Tropomyosin alpha-1 chain

1

6

High-throughput

0.536

High

535955

MYH3
Myosin-3

1

10

High-throughput

0.536

High

539580

PYGB
Glycogen phosphorylase, brain form

1

2

High-throughput

0.536

High

539645

PYGM
Glycogen phosphorylase, muscle form

1

2

High-throughput

0.536

High

556886

MYH1
Myosin-1

1

10

High-throughput

0.536

High

563038

MYH6
Myosin-6

1

10

High-throughput

0.536

High

563076

MYH8
Myosin-8

1

10

High-throughput

0.536

High

569032

ENOB
Beta-enolase

1

3

High-throughput

0.536

High

658791

JAK1
Tyrosine-protein kinase JAK1

1

8

High-throughput

0.536

High

703085

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.536

High

733464

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

773797

ACTN2
Alpha-actinin-2

1

10

High-throughput

0.536

High

777330

AHR
Aryl hydrocarbon receptor

1

4

High-throughput

0.536

High

832590

ETV3
ETS translocation variant 3

1

4

High-throughput

0.536

High

861327

MAP1B
Microtubule-associated protein 1B

1

8

High-throughput

0.536

High

895143

EMD
Emerin

1

1

High-throughput

0.536

High

896470

ERF
ETS domain-containing transcription factor ERF

1

4

High-throughput

0.536

High

907620

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.536

High

913610

KIF11
Kinesin-like protein KIF11

1

1

High-throughput

0.536

High

946217

MLF1
Myeloid leukemia factor 1

1

3

High-throughput

0.536

High

1029780

FOXK2
Forkhead box protein K2

1

3

High-throughput

0.536

High

1044439

ZNF92
Zinc finger protein 92

1

1

High-throughput

0.536

High

1060500

DPOE1
DNA polymerase epsilon catalytic subunit A

1

2

High-throughput

0.536

High

1095067

DUS4
Dual specificity protein phosphatase 4

1

6

High-throughput

0.536

High

1106243

MYO9B
Unconventional myosin-IXb

1

12

High-throughput

0.536

High

1109678

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

5

High-throughput

0.536

High

1110317

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

High-throughput

0.536

High

1111498

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

4

High-throughput

0.536

High

1116704

RIN1
Ras and Rab interactor 1

1

2

High-throughput

0.536

High

1187177

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

2

High-throughput

0.536

High

1192002

TBB8
Tubulin beta-8 chain

1

2

High-throughput

0.536

High

1200932

WDR81
WD repeat-containing protein 81

1

3

High-throughput

0.536

High

1201909

PKHG4
Puratrophin-1

1

4

High-throughput

0.536

High

1208970

DCA10
DDB1- and CUL4-associated factor 10

1

4

High-throughput

0.536

High

1225103

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

7

High-throughput

0.536

High

1231889

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

1

High-throughput

0.536

High

1244747

KLD10
Kelch domain-containing protein 10

1

2

High-throughput

0.536

High

1247036

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.536

High

1257958

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

4

High-throughput

0.536

High

1259561

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.536

High

1322669

RPTOR
Regulatory-associated protein of mTOR

1

5

High-throughput

0.536

High

1325021

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

2

High-throughput

0.536

High

1357895

CTF18
Chromosome transmission fidelity protein 18 homolog

1

3

High-throughput

0.536

High

1359647

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

8

High-throughput

0.536

High

1361933

TITIN
Titin

1

12

High-throughput

0.536

High

1382132

MYL11
Myosin regulatory light chain 11

1

6

High-throughput

0.536

High

1384572

NACC2
Nucleus accumbens-associated protein 2

1

9

High-throughput

0.536

High

1392831

TONSL
Tonsoku-like protein

1

5

High-throughput

0.536

High

1396323

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

6

High-throughput

0.536

High

1401983

GCP6
Gamma-tubulin complex component 6

1

1

High-throughput

0.536

High

1402079

TRIB1
Tribbles homolog 1

1

7

High-throughput

0.536

High

1402109

IF140
Intraflagellar transport protein 140 homolog

1

3

High-throughput

0.536

High

1406301

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

2

High-throughput

0.536

High

1407013

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.536

High

1408357

PKP2
Plakophilin-2

1

6

High-throughput

0.536

High

1416747

OSB10
Oxysterol-binding protein-related protein 10

1

3

High-throughput

0.536

High

1433408

SAV1
Protein salvador homolog 1

1

8

High-throughput

0.536

High

1435162

ESRP2
Epithelial splicing regulatory protein 2

1

8

High-throughput

0.536

High

1438158

IF122
Intraflagellar transport protein 122 homolog

1

5

High-throughput

0.536

High

1446893

TF7L2
Transcription factor 7-like 2

1

3

High-throughput

0.536

High

1447731

PDLI7
PDZ and LIM domain protein 7

1

4

High-throughput

0.536

High

1449757

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

1

High-throughput

0.536

High

1460790

MYH2
Myosin-2

1

10

High-throughput

0.536

High

1460791

AKP8L
A-kinase anchor protein 8-like

1

2

High-throughput

0.536

High

1460793

TBD2B
TBC1 domain family member 2B

1

3

High-throughput

0.536

High

1460794

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.536

High

1460798

IRAK3
Interleukin-1 receptor-associated kinase 3

1

1

High-throughput

0.536

High

1460799

MYH4
Myosin-4

1

10

High-throughput

0.536

High

1460800

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

1

High-throughput

0.536

High

322477

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

437606

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

0

High-throughput

0.513

High

1118833

TF2H2
General transcription factor IIH subunit 2

1

0

High-throughput

0.513

High

1143022

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.513

High

1152973

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.513

High

1244276

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.513

High

1294738

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.513

High

1339892

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.513

High

1390830

CPNE2
Copine-2

1

0

High-throughput

0.513

High

1420258

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1453288

TF2L1
Transcription factor CP2-like protein 1

1

0

High-throughput

0.513

High

1460756

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.513

High

1460789

AKA11
A-kinase anchor protein 11

1

0

High-throughput

0.513

High

791819

SYUA
Alpha-synuclein

1

4

Small-scale

0.501

High

598232

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

High-throughput

0.489

High

1280086

FRMD5
FERM domain-containing protein 5

1

4

High-throughput

0.489

High

1281677

ZER1
Protein zer-1 homolog

1

3

High-throughput

0.489

High

1312087

DJC10
DnaJ homolog subfamily C member 10

1

1

High-throughput

0.489

High

1323933

KLH34
Kelch-like protein 34

1

3

High-throughput

0.489

High

1383705

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.489

High

173526

XPO1
Exportin-1

1

5

High-throughput

0.479

High

294504

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

331398

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

373444

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

397178

ESR1
Estrogen receptor

1

5

Small-scale

0.479

High

714502

PML
Protein PML

1

9

High-throughput

0.479

High

937961

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

985944

RL11
Large ribosomal subunit protein uL5

1

2

Small-scale

0.479

High

1116113

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.479

High

1391839

AURKB
Aurora kinase B

1

6

High-throughput

0.479

High

1410827

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

8

Small-scale

0.479

High

1438564

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

3

Small-scale

0.479

High

1460795

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

3

Small-scale

0.479

High

1460797

ASB4
Ankyrin repeat and SOCS box protein 4

1

8

High-throughput

0.479

High

274799

DNJB6
DnaJ homolog subfamily B member 6

1

0

Small-scale

0.458

High

1253011

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

564533

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

1198801

Q53FC7
Heat shock 70 kDa protein 6

1

5

High-throughput

0.437

High

841089

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.426

High

188104

MOT6
Monocarboxylate transporter 6

2

0

High-throughput

0.316

High

1200598

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

391760

STAT
Statherin

1

0

High-throughput

0.279

Low

1129304

BLTP2
Bridge-like lipid transfer protein family member 2

1

0

High-throughput

0.279

Low

1245149

RHDF2
Inactive rhomboid protein 2

1

0

High-throughput

0.279

Low

1316010

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1431588

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

1450072

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

1460796

DLGP4
Disks large-associated protein 4

1

0

High-throughput

0.279

Low

1213442

AT7L2
Ataxin-7-like protein 2

1

0

High-throughput

0.251

Low

1458880

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025