HitPredict

Interactor 1: TRI38 (O00635)
E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet)
Gene: TRIM38

Interactor 2: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 321
+	Hs
		584907 RO52_HUMAN (1-462): 2.44e-152: 443: 41.39		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		584923 RO52_HUMAN (1-462): 2.44e-152: 443: 41.39		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		584916 RO52_HUMAN (1-462): 2.44e-152: 443: 41.39		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		1336390 TRI39_HUMAN (7-465): 2.82e-147: 431: 37.30		UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33
+	Hs
		849453 TRI39_HUMAN (7-465): 2.82e-147: 431: 37.30		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		919870 TRI39_HUMAN (7-465): 2.82e-147: 431: 37.30		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		895921 TRI39_HUMAN (7-465): 2.82e-147: 431: 37.30		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		135045 TRI38_HUMAN (1-465): 7.78e-146: 426: 100.00		UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33
+	Hs
		135012 TRI38_HUMAN (1-465): 7.78e-146: 426: 100.00		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		135019 TRI38_HUMAN (1-465): 7.78e-146: 426: 100.00		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		135017 TRI38_HUMAN (1-465): 7.78e-146: 426: 100.00		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		584910 RO52_HUMAN (1-462): 2.44e-152: 443: 41.39		UB2E1_HUMAN (3-153): 1.32e-66: 209: 25.17
+	Hs
		895851 TRI58_HUMAN (1-464): 5.62e-145: 425: 39.23		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		1297370 TRI39_HUMAN (7-465): 2.82e-147: 431: 37.30		UB2E2_HUMAN (3-153): 5.78e-68: 212: 23.18
+	Hs
		1282350 TRI39_HUMAN (7-465): 2.82e-147: 431: 37.30		UB2E3_HUMAN (3-153): 1.57e-67: 211: 24.50
+	Hs
		851889 TRI39_HUMAN (7-465): 2.82e-147: 431: 37.30		UB2E1_HUMAN (3-153): 1.32e-66: 209: 25.17
+	Hs
		135040 TRI38_HUMAN (1-465): 7.78e-146: 426: 100.00		UB2E2_HUMAN (3-153): 5.78e-68: 212: 23.18
+	Hs
		135036 TRI38_HUMAN (1-465): 7.78e-146: 426: 100.00		UB2E3_HUMAN (3-153): 1.57e-67: 211: 24.50
+	Hs
		135013 TRI38_HUMAN (1-465): 7.78e-146: 426: 100.00		UB2E1_HUMAN (3-153): 1.32e-66: 209: 25.17
+	Hs
		135922 RO52_HUMAN (1-462): 2.44e-152: 443: 41.39		UBE2C_HUMAN (9-145): 2.39e-20: 88.2: 35.77