HitPredict

Interactor 1: FAK2 (Q9QVP9)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: Ptk2b

Interactor 2: ASAP1 (Q9QWY8)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
Gene: ASAP1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.756

Property	Details
Experiments	12771146
Identification Methods	two hybrid, pull down, experimental interaction detection, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0043197 - dendritic spine GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1009 Mm			1 1147
+	Hs
		195794 FAK2_HUMAN (1-1009): 0: 1059: 95.44		ASAP2_HUMAN (21-981): 0: 615: 53.73
+	Hs
		983689 FAK1_HUMAN (39-1000): 0: 803: 44.05		ASAP1_HUMAN (17-1147): 0: 788: 94.78
+	Mm
		1112655 FAK2_MOUSE (1-1009): 0: 1048: 100.00		AGAP2_MOUSE (394-675): 1.94e-86: 306: 29.02
+	Mm
		93394 E9Q2A6_MOUSE (1-1009): 0: 1006: 95.84		AGAP2_MOUSE (394-675): 1.94e-86: 306: 29.02
+	Hs
		523197 SRC_HUMAN (256-694): 2.06e-129: 404: 26.92		ASAP1_HUMAN (17-1147): 0: 788: 94.78
+	Hs
		412404 FYN_HUMAN (247-694): 2.21e-127: 399: 26.13		ASAP1_HUMAN (17-1147): 0: 788: 94.78
+	Hs
		49637 FAK2_HUMAN (1-1009): 0: 1059: 95.44		RHG10_HUMAN (919-1145): 5.47e-18: 91.9: 17.24
+	Mm
		1167905 FAK2_MOUSE (1-1009): 0: 1048: 100.00		RHG10_MOUSE (932-1145): 4.46e-18: 91.9: 16.74
+	Mm
		710137 FAK1_MOUSE (39-1000): 0: 799: 44.05		AGAP2_MOUSE (394-675): 1.94e-86: 306: 29.02
+	Hs
		195782 SRC_HUMAN (256-694): 2.06e-129: 404: 26.92		ASAP2_HUMAN (21-981): 0: 615: 53.73
+	Hs
		195776 FYN_HUMAN (247-694): 2.21e-127: 399: 26.13		ASAP2_HUMAN (21-981): 0: 615: 53.73
+	Hs
		195777 YES_HUMAN (272-694): 3.51e-127: 398: 27.23		ASAP2_HUMAN (21-981): 0: 615: 53.73
+	Hs
		983690 FAK1_HUMAN (39-1000): 0: 803: 44.05		RHG26_HUMAN (1075-1145): 8.83e-09: 61.8: 27.78
+	Hs
		522992 SRC_HUMAN (256-694): 2.06e-129: 404: 26.92		ACAP1_HUMAN (43-710): 4.91e-140: 442: 21.06
+	Mm
		403434 SRC_MOUSE (188-694): 1.11e-128: 402: 24.07		AGAP2_MOUSE (394-675): 1.94e-86: 306: 29.02
+	Hs
		412284 FYN_HUMAN (247-694): 2.21e-127: 399: 26.13		ARAP2_HUMAN (123-635): 6.76e-59: 224: 13.72
+	Hs
		523208 SRC_HUMAN (256-694): 2.06e-129: 404: 26.92		AGAP1_HUMAN (376-676): 3.84e-58: 218: 27.42
+	Hs
		411807 LCK_HUMAN (272-694): 8.62e-127: 396: 28.97		ARAP2_HUMAN (123-635): 6.76e-59: 224: 13.72
+	Zm
		24292 A0A1D6IZ90_MAIZE (185-681): 3.4e-143: 443: 15.96		A0A1D6IFU2_MAIZE (441-577): 3.27e-16: 85.1: 37.23
+	Mm
		1142639 ERBB4_MOUSE (413-885): 1.02e-121: 404: 28.57		ASAP2_MOUSE (978-1147): 1.55e-19: 96.9: 39.18