Protein: HAVR2
Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)

Gene: HAVR2, HAVCR2
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q8TDQ0

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0002250 - adaptive immune response
GO:0002281 - macrophage activation involved in immune response
GO:0002519 - natural killer cell tolerance induction
GO:0002652 - regulation of tolerance induction dependent upon immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135967

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

2

2

High-throughput

0.811

High

690110

AVR2A
Activin receptor type-2A

2

3

High-throughput

0.811

High

787213

BMR1A
Bone morphogenetic protein receptor type-1A

2

3

High-throughput

0.811

High

835581

TSN7
Tetraspanin-7

2

1

High-throughput

0.811

High

839054

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

2

2

High-throughput

0.811

High

839165

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

2

2

High-throughput

0.811

High

1157541

PKN2
Serine/threonine-protein kinase N2

2

1

High-throughput

0.811

High

1349719

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

2

1

High-throughput

0.811

High

247391

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

2

0

High-throughput

0.770

High

1129964

MELK
Maternal embryonic leucine zipper kinase

2

0

High-throughput

0.770

High

1351515

S67A1
Solute carrier family 67 member A1

2

0

High-throughput

0.770

High

1243026

PKN3
Serine/threonine-protein kinase N3

2

1

High-throughput

0.726

High

1006207

CNTP1
Contactin-associated protein 1

3

0

High-throughput

0.715

High

1351542

TTF2
Transcription termination factor 2

3

0

High-throughput

0.715

High

410957

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.691

High

567242

CEAM1
Cell adhesion molecule CEACAM1

1

1

Small-scale

0.690

High

322745

RHBT3
Rho-related BTB domain-containing protein 3

2

0

High-throughput

0.679

High

1206336

WDR44
WD repeat-containing protein 44

2

0

High-throughput

0.679

High

1336703

CBPC5
Cytosolic carboxypeptidase-like protein 5

2

0

High-throughput

0.679

High

1351514

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

2

0

High-throughput

0.679

High

1351531

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

2

2

High-throughput

0.675

High

699811

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

2

Small-scale

0.667

High

1351517

ORAI1
Calcium release-activated calcium channel protein 1

1

0

High-throughput

0.656

High

1351526

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.656

High

1351540

NOCT
Nocturnin

1

0

High-throughput

0.656

High

168878

PLD2
Phospholipase D2

3

0

High-throughput

0.634

High

318364

MYO1D
Unconventional myosin-Id

3

0

High-throughput

0.634

High

1351527

ZDHC5
Palmitoyltransferase ZDHHC5

3

0

High-throughput

0.634

High

1351537

CLDN1
Claudin domain-containing protein 1

3

0

High-throughput

0.634

High

65358

TCAF2
TRPM8 channel-associated factor 2

2

1

High-throughput

0.628

High

658743

JAK1
Tyrosine-protein kinase JAK1

2

5

High-throughput

0.628

High

714638

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

4

High-throughput

0.628

High

1112373

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

2

1

High-throughput

0.628

High

1130710

DIP2A
Disco-interacting protein 2 homolog A

2

3

High-throughput

0.628

High

1351521

PKP4
Plakophilin-4

2

1

High-throughput

0.628

High

1351523

PKP2
Plakophilin-2

2

1

High-throughput

0.628

High

1351545

NISCH
Nischarin

2

1

High-throughput

0.628

High

125538

LEG9
Galectin-9

1

2

Small-scale

0.618

High

422692

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.614

High

1225723

LPCT4
Lysophospholipid acyltransferase LPCAT4

3

1

High-throughput

0.604

High

1351522

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

3

1

High-throughput

0.604

High

1351536

AT132
Polyamine-transporting ATPase 13A2

3

2

High-throughput

0.604

High

505447

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

2

0

High-throughput

0.602

High

914828

DGKQ
Diacylglycerol kinase theta

2

0

High-throughput

0.602

High

1063066

S20A2
Sodium-dependent phosphate transporter 2

2

0

High-throughput

0.602

High

1349964

CERK1
Ceramide kinase

2

0

High-throughput

0.602

High

1351519

MYADM
Myeloid-associated differentiation marker

2

0

High-throughput

0.602

High

1351535

IL1AP
Interleukin-1 receptor accessory protein

2

0

High-throughput

0.602

High

619081

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

Small-scale

0.593

High

440156

LCK
Tyrosine-protein kinase Lck

2

2

Small-scale

0.588

High

1217542

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

0

High-throughput

0.578

High

1351549

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

0

High-throughput

0.578

High

641967

CD9
CD9 antigen

1

1

High-throughput

0.575

High

931817

EPHB3
Ephrin type-B receptor 3

1

2

High-throughput

0.575

High

944004

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.575

High

136415

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

6

High-throughput

0.574

High

331776

MTMR5
Myotubularin-related protein 5

2

1

High-throughput

0.574

High

1351513

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

6

High-throughput

0.574

High

1351539

DIP2B
Disco-interacting protein 2 homolog B

2

3

High-throughput

0.574

High

856827

BAG6
Large proline-rich protein BAG6

1

3

Small-scale

0.553

High

572325

CBPM
Carboxypeptidase M

1

0

High-throughput

0.546

High

1351543

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.546

High

1351546

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.546

High

339545

ACSL3
Fatty acid CoA ligase Acsl3

1

1

High-throughput

0.536

High

1139021

SNX17
Sorting nexin-17

1

1

High-throughput

0.536

High

1135224

Q149M6
Exophilin 5

2

1

High-throughput

0.533

High

127377

LEG8
Galectin-8

1

2

High-throughput

0.514

High

1351520

Q96T11
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.514

High

1191906

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.513

High

1351528

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.513

High

1337859

EXPH5
Exophilin-5

2

1

High-throughput

0.504

High

440646

FYN
Tyrosine-protein kinase Fyn

1

2

Small-scale

0.484

High

849076

ZAP70
Tyrosine-protein kinase ZAP-70

1

4

Small-scale

0.484

High

849211

KSYK
Tyrosine-protein kinase SYK

1

6

Small-scale

0.484

High

161302

ENC1
Ectoderm-neural cortex protein 1

1

0

High-throughput

0.481

High

229241

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.481

High

1094313

LCP2
Lymphocyte cytosolic protein 2

1

0

Small-scale

0.481

High

1351533

AT131
Endoplasmic reticulum transmembrane helix translocase

1

2

High-throughput

0.445

High

1351544

SH2B3
SH2B adapter protein 3

1

4

Small-scale

0.445

High

1351547

TCAF1
TRPM8 channel-associated factor 1

1

1

High-throughput

0.445

High

1351550

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.445

High

1351534

SH22A
SH2 domain-containing protein 2A

1

7

Small-scale

0.442

High

70012

D11L8
Putative ATP-dependent DNA helicase DDX11-like protein 8

1

0

High-throughput

0.426

High

335697

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

0

High-throughput

0.426

High

442767

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

584569

VAV
Proto-oncogene vav

1

0

Small-scale

0.426

High

951772

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.426

High

1060465

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.426

High

1139894

LRC14
Leucine-rich repeat-containing protein 14

1

0

High-throughput

0.426

High

1351516

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.426

High

1351525

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

1351530

AMPB
Aminopeptidase B

1

0

High-throughput

0.426

High

749627

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

1

High-throughput

0.407

High

1279115

GOGA7
Golgin subfamily A member 7

3

0

High-throughput

0.345

High

1313209

PLPL6
Patatin-like phospholipase domain-containing protein 6

3

0

High-throughput

0.345

High

345204

ZMYM6
Zinc finger MYM-type protein 6

2

0

High-throughput

0.328

High

1198311

TIGD5
Tigger transposable element-derived protein 5

2

0

High-throughput

0.328

High

1216010

M3K21
Mitogen-activated protein kinase kinase kinase 21

2

0

High-throughput

0.328

High

1280658

PKHH3
Pleckstrin homology domain-containing family H member 3

2

0

High-throughput

0.328

High

1310051

DEN6A
Protein DENND6A

2

0

High-throughput

0.328

High

1333162

KDM1B
Lysine-specific histone demethylase 2

2

0

High-throughput

0.328

High

1324421

TM86A
Lysoplasmalogenase TMEM86A

2

0

High-throughput

0.316

High

1351518

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.316

High

166961

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.279

Low

790164

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.279

Low

1231853

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.279

Low

1243425

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

0

High-throughput

0.279

Low

1339309

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.279

Low

1341112

WDR36
WD repeat-containing protein 36

1

0

High-throughput

0.279

Low

1351529

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

1

0

High-throughput

0.279

Low

1351538

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.279

Low

1351541

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.269

Low

214229

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

0

High-throughput

0.232

Low

243985

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.232

Low

317466

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.232

Low

1004310

3BP2
SH3 domain-binding protein 2

1

0

Small-scale

0.232

Low

1224757

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.232

Low

1351524

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.232

Low

1351532

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

1351548

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025