Protein: ACSL1
Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24)

Gene: ACSL1
Organism: Homo sapiens
Interactions: 89
UniProt ID: P33121

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0001676 - long-chain fatty acid metabolic process
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

749601

FAS
Fatty acid synthase

1

0

High-throughput

0.656

High

182477

GP182
G-protein coupled receptor 182

2

4

High-throughput

0.601

High

240882

PRKN
E3 ubiquitin-protein ligase parkin

2

6

Small-scale

0.584

High

409561

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

3

High-throughput

0.536

High

688694

NKG2D
NKG2-D type II integral membrane protein

1

5

High-throughput

0.536

High

749598

EAA3
Excitatory amino acid transporter 3

1

5

High-throughput

0.536

High

749609

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.536

High

749614

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

1

High-throughput

0.536

High

749630

AQP3
Aquaporin-3

1

2

High-throughput

0.536

High

749637

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.536

High

749611

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

749622

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

749624

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

749626

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

749613

S39AC
Zinc transporter ZIP12

2

7

High-throughput

0.504

High

165910

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.489

High

289307

FCN3
Ficolin-3

1

1

High-throughput

0.489

High

688531

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

5

High-throughput

0.489

High

732955

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

2

High-throughput

0.489

High

733294

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.489

High

749594

APJ
Apelin receptor

1

2

High-throughput

0.489

High

749604

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

1

High-throughput

0.489

High

749616

T150A
Transmembrane protein 150A

1

1

High-throughput

0.489

High

749617

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

3

High-throughput

0.489

High

749619

S22A9
Organic anion transporter 7

1

5

High-throughput

0.489

High

749639

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

1

High-throughput

0.489

High

749645

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

1

High-throughput

0.489

High

749646

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

1

High-throughput

0.489

High

749647

GPR55
G-protein coupled receptor 55

1

6

High-throughput

0.489

High

749649

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.489

High

749650

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

467775

MCR
Mineralocorticoid receptor

1

6

High-throughput

0.481

High

105440

APRIO
Alternative prion protein

1

3

High-throughput

0.479

High

137662

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.479

High

208470

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.479

High

274987

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

2

High-throughput

0.479

High

403864

GCR
Glucocorticoid receptor

1

6

Small-scale

0.479

High

411453

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

606318

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

633885

ATP4A
Potassium-transporting ATPase alpha chain 1

1

3

Small-scale

0.479

High

713894

PML
Protein PML

1

2

High-throughput

0.479

High

749605

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

749628

RBCC1
RB1-inducible coiled-coil protein 1

1

3

High-throughput

0.479

High

749633

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

749638

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

1

High-throughput

0.479

High

749644

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

279121

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

749606

BDH
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

749618

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

749620

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

184006

S22A1
Solute carrier family 22 member 1

1

5

High-throughput

0.445

High

379906

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

563296

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

749597

EAA2
Excitatory amino acid transporter 2

1

5

High-throughput

0.445

High

749600

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.445

High

749603

VMAT1
Chromaffin granule amine transporter

1

3

High-throughput

0.445

High

749625

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

2

High-throughput

0.445

High

749632

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.445

High

749607

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

371298

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

588022

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

694736

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

749593

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

749595

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

749612

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.437

High

749615

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

749623

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

High-throughput

0.437

High

749634

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

749640

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

749641

ECT2
Protein ECT2

1

1

High-throughput

0.437

High

749643

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

261106

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

749636

SFXN3
Sideroflexin-3

1

0

High-throughput

0.426

High

749648

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.426

High

229262

ANGL7
Angiopoietin-related protein 7

1

1

High-throughput

0.407

High

749592

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.407

High

749596

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

2

High-throughput

0.407

High

749599

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.407

High

749627

HAVR2
Hepatitis A virus cellular receptor 2

1

1

High-throughput

0.407

High

749631

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.407

High

749642

S39A2
Zinc transporter ZIP2

1

7

High-throughput

0.407

High

749602

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.373

High

260839

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

749608

MESP2
Mesoderm posterior protein 2

1

0

High-throughput

0.279

Low

749629

ITLN1
Intelectin-1

1

0

High-throughput

0.279

Low

317315

ACL6B
Actin-like protein 6B

1

0

High-throughput

0.232

Low

749610

EFNB3
Ephrin-B3

1

0

High-throughput

0.232

Low

749621

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.232

Low

749635

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025