Interactor 1: SAE1 (Q9UBE0)
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]
Gene: SAE1
Interactor 2: SAE2 (Q9UBT2)
SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)
Gene: UBA2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26496610, 17353931, 26264872, 10217437, 10187858, 35271311, 23601649, 35235311, 37071682, 9920803, 16189514, 28514442, 33961781, 20164921, 21120624, 31515488, 15660128 |
| Identification Methods | affinity chromatography technology, enzymatic study, pull down, cross-linking study, two hybrid, molecular sieving, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid array, x-ray crystallography and 1 others
more... |
| Interaction Type | physical association, direct interaction, other modification, sumoylation reaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | ThiF~ThiF, ThiF~UAE_UbL |
| Common GO terms | GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016925 - protein sumoylation GO:0019948 - SUMO activating enzyme activity GO:0031510 - SUMO activating enzyme complex and 3 others more... |
| Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
