Protein: HIC2
Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30)

Gene: HIC2
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q96JB3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001817 - regulation of cytokine production
GO:0002682 - regulation of immune system process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1133384

ZN169
Zinc finger protein 169

2

20

High-throughput

0.811

High

1226645

E4F1
Transcription factor E4F1

2

20

High-throughput

0.811

High

1385030

ZBT8A
Zinc finger and BTB domain-containing protein 8A

2

19

High-throughput

0.794

High

1394764

EHMT2
Histone-lysine N-methyltransferase EHMT2

2

3

High-throughput

0.783

High

1128670

ZN460
Zinc finger protein 460

2

18

High-throughput

0.776

High

1103317

CTBP1
C-terminal-binding protein 1

4

6

High-throughput

0.699

High

1127702

HIC1
Hypermethylated in cancer 1 protein

1

20

Small-scale

0.656

High

1394763

HIC2
Hypermethylated in cancer 2 protein

1

17

Small-scale

0.656

High

1394767

CRBN
Protein cereblon

1

3

Small-scale

0.647

High

339825

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.646

High

230655

PRIC3
Prickle planar cell polarity protein 3

2

19

High-throughput

0.628

High

1394772

LZTS2
Leucine zipper putative tumor suppressor 2

2

8

High-throughput

0.628

High

1114003

CUL3
Cullin-3

1

20

High-throughput

0.618

High

1114998

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

1394770

BARD1
BRCA1-associated RING domain protein 1

1

6

High-throughput

0.618

High

1394781

KLF15
Krueppel-like factor 15

1

19

High-throughput

0.618

High

941520

CTBP2
C-terminal-binding protein 2

2

6

High-throughput

0.611

High

139406

VMA5A
von Willebrand factor A domain-containing protein 5A

2

0

High-throughput

0.602

High

1394777

YYAP1
YY1-associated protein 1

2

0

High-throughput

0.602

High

1295385

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

1

High-throughput

0.574

High

229791

CALU
Calumenin

2

4

High-throughput

0.558

High

1340309

CEP70
Centrosomal protein of 70 kDa

2

5

High-throughput

0.553

High

407691

S100B
Protein S100-B

1

3

High-throughput

0.536

High

938022

FOXA3
Hepatocyte nuclear factor 3-gamma

1

3

High-throughput

0.536

High

1332562

TEX19
Testis-expressed protein 19

1

2

High-throughput

0.536

High

1394771

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

1394774

FOXQ1
Forkhead box protein Q1

1

3

High-throughput

0.536

High

1394779

FOXJ2
Forkhead box protein J2

1

2

High-throughput

0.536

High

1394780

FBLN5
Fibulin-5

1

20

High-throughput

0.536

High

570959

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

1330469

HORM2
HORMA domain-containing protein 2

1

0

High-throughput

0.513

High

422889

A4
Amyloid-beta precursor protein

1

14

High-throughput

0.501

High

1394784

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

2

High-throughput

0.489

High

1394782

PNMA2
Paraneoplastic antigen Ma2

1

4

High-throughput

0.489

High

143190

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

190086

FOXP2
Forkhead box protein P2

1

5

Small-scale

0.479

High

260306

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

342290

BRD1
Bromodomain-containing protein 1

1

5

High-throughput

0.479

High

474209

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

905035

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

1029908

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

1067604

EP300
Histone acetyltransferase p300

1

13

High-throughput

0.479

High

1087944

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1133604

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1220735

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

1271082

RNF44
RING finger protein 44

1

1

Small-scale

0.479

High

1308716

FOXP4
Forkhead box protein P4

1

7

Small-scale

0.479

High

1394765

CIC
Protein capicua homolog

1

12

High-throughput

0.479

High

1394769

FEV
Protein FEV

1

1

High-throughput

0.479

High

1394775

FOXP1
Forkhead box protein P1

1

4

Small-scale

0.479

High

1394783

BRPF3
Bromodomain and PHD finger-containing protein 3

1

4

High-throughput

0.479

High

319982

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

892713

DNLI4
DNA ligase 4

1

0

High-throughput

0.458

High

1394776

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

430243

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

1142730

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.438

High

1393598

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

1394766

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1394768

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

1394778

TBCC1
TBCC domain-containing protein 1

2

0

High-throughput

0.328

High

1394773

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025