HitPredict

Interactor 1: MED13 (Q9UHV7)
Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
Gene: MED13

Interactor 2: MED23 (Q9ULK4)
Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)
Gene: MED23

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.711

Property	Details
Experiments	29568061, 25281560, 24981860, 33961781, 12421765
Identification Methods	proximity labelling technology, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex GO:0060261 - positive regulation of transcription initiation by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 2174 Hs			1 1368
+	Hs
		1174787 MD13L_HUMAN (2-2174): 0: 3190: 51.68		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Dm
		1182318 MED13_DROME (776-947): 6.01e-50: 198: 25.11		MED23_DROME (1-1336): 0: 1744: 48.34
+	Ce
		1014362 MED13_CAEEL (8-255): 7.75e-92: 336: 31.05		MED23_CAEEL (44-1342): 0: 1394: 20.98