Protein: RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3 (TFIIH subunit XPD) (EC 5.6.2.3) (DNA 5'-3' helicase RAD3) (DNA repair helicase RAD3) (RNA polymerase II transcription factor B subunit RAD3) (TFB subunit RAD3)

Gene: RAD3
Organism: Saccharomyces cerevisiae S288C
Interactions: 94
UniProt ID: P06839

Gene Ontology (top 5):
GO:0000019 - regulation of mitotic recombination
GO:0000112 - nucleotide-excision repair factor 3 complex
GO:0000439 - transcription factor TFIIH core complex
GO:0003684 - damaged DNA binding
GO:0003678 - DNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449362

TFB3
RNA polymerase II transcription factor B subunit 3

12

3

Small-scale

0.978

High

449325

TFB1
General transcription and DNA repair factor IIH subunit TFB1

12

2

Small-scale

0.972

High

449364

SSL1
General transcription and DNA repair factor IIH subunit SSL1

11

4

Small-scale

0.972

High

449358

RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2

10

2

Small-scale

0.751

High

440815

KIN28
Serine/threonine-protein kinase KIN28

7

3

Small-scale

0.737

High

449321

RAD14
DNA repair protein RAD14

1

1

Small-scale

0.724

High

449349

MET18
DNA repair/transcription protein MET18/MMS19

5

4

Small-scale

0.718

High

449361

TFB2
General transcription and DNA repair factor IIH subunit TFB2

6

3

Small-scale

0.714

High

449369

TFB4
General transcription and DNA repair factor IIH subunit TFB4

5

2

Small-scale

0.709

High

449334

CCL1
Cyclin CCL1

5

2

Small-scale

0.703

High

449318

MAS5
Mitochondrial protein import protein MAS5

4

4

High-throughput

0.691

High

449309

VATA
V-type proton ATPase catalytic subunit A

3

4

High-throughput

0.671

High

449359

PRS8
26S proteasome regulatory subunit 8 homolog

3

1

High-throughput

0.667

High

449326

PRS6B
26S proteasome regulatory subunit 6B homolog

3

0

High-throughput

0.629

High

449345

GPP2
Glycerol-1-phosphate phosphohydrolase 2

2

1

High-throughput

0.621

High

449295

TBA1
Tubulin alpha-1 chain

2

2

High-throughput

0.618

High

449340

RPN1
26S proteasome regulatory subunit RPN1

2

1

High-throughput

0.601

High

449296

TBA3
Tubulin alpha-3 chain

2

2

High-throughput

0.588

High

449335

GBLP
Small ribosomal subunit protein RACK1

2

2

High-throughput

0.588

High

449339

ECM29
Proteasome component ECM29

2

1

High-throughput

0.588

High

449298

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.586

High

449316

DBP5
ATP-dependent RNA helicase DBP5

1

0

Small-scale

0.586

High

386516

TBB
Tubulin beta chain

2

1

High-throughput

0.584

High

449328

GCN1
eIF-2-alpha kinase activator GCN1

2

0

High-throughput

0.563

High

449342

RPN10
26S proteasome regulatory subunit RPN10

2

0

High-throughput

0.563

High

449352

GCN20
Protein GCN20

2

0

High-throughput

0.563

High

449293

PYR1
Multifunctional protein URA2

2

0

High-throughput

0.559

High

449306

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.559

High

449315

HSP60
Heat shock protein 60, mitochondrial

2

0

High-throughput

0.559

High

449300

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.552

High

449346

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

415095

ADT1
ADP,ATP carrier protein 1

1

2

High-throughput

0.536

High

449347

RAD26
DNA repair and recombination protein RAD26

1

1

High-throughput

0.536

High

449350

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

1

High-throughput

0.536

High

449366

THI22
Thiamine biosynthesis protein THI22

1

1

High-throughput

0.536

High

449373

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

Small-scale

0.529

High

449308

NCPR
NADPH--cytochrome P450 reductase

1

1

High-throughput

0.515

High

364868

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.513

High

449314

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.513

High

449331

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.513

High

449341

YHS2
MIP18 family protein YHR122W

1

6

Small-scale

0.501

High

449365

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

6

Small-scale

0.501

High

366880

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.500

High

392001

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.500

High

404999

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.500

High

449292

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.500

High

449305

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.500

High

449307

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.500

High

449313

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.500

High

449329

MDJ1
DnaJ homolog 1, mitochondrial

1

5

High-throughput

0.500

High

449367

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

449311

ADT3
ADP,ATP carrier protein 3

1

2

High-throughput

0.489

High

449368

RPN8
26S proteasome regulatory subunit RPN8

1

1

High-throughput

0.489

High

449319

MSH2
DNA mismatch repair protein MSH2

1

0

Small-scale

0.486

High

368543

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.479

High

408268

GAL1
Galactokinase

1

0

High-throughput

0.479

High

416338

HXKA
Hexokinase-1

1

0

High-throughput

0.479

High

449301

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

449304

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

449323

BMH1
Protein BMH1

1

0

High-throughput

0.479

High

449344

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.479

High

449354

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.479

High

449371

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.479

High

449302

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

449356

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

449357

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.479

High

449322

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

449330

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

449370

YRA1
RNA annealing protein YRA1

1

0

Small-scale

0.458

High

449360

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.457

High

449312

ADT2
ADP,ATP carrier protein 2

1

2

High-throughput

0.457

High

449353

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.457

High

449294

RAD2
DNA repair protein RAD2

1

3

Small-scale

0.445

High

449297

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.445

High

449299

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

449324

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

449327

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

High-throughput

0.445

High

449332

T2EA
Transcription initiation factor IIE subunit alpha

1

1

Small-scale

0.445

High

449337

CHK1
Serine/threonine-protein kinase CHK1

1

0

High-throughput

0.438

High

394107

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

449333

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.426

High

449372

TFB5
General transcription and DNA repair factor IIH subunit TFB5

1

0

Small-scale

0.426

High

449363

CLU
Clustered mitochondria protein 1

2

0

High-throughput

0.307

High

449310

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

449320

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

0

High-throughput

0.279

Low

449336

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

449338

YB34
Uncharacterized protein YBR184W

1

0

High-throughput

0.279

Low

449343

HXT6
High-affinity hexose transporter HXT6

1

0

High-throughput

0.279

Low

449355

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

449303

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

449317

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

449348

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

427069

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

449351

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025