HitPredict

Interactor 1: MED13 (Q9UHV7)
Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
Gene: MED13

Interactor 2: MED31 (Q9Y3C7)
Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (hSOH1)
Gene: MED31

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.671

Property	Details
Experiments	29568061, 24981860, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex GO:0060261 - positive regulation of transcription initiation by RNA polymerase II
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 2174 Hs			1 131
+	Hs
		1174791 MD13L_HUMAN (2-2174): 0: 3190: 51.68		MED31_HUMAN (1-131): 4.08e-63: 190: 100.00
+	Dm
		1182280 MED13_DROME (776-947): 6.01e-50: 198: 25.11		MED31_DROME (6-115): 7.51e-54: 169: 70.00