HitPredict

Interactor 1: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2610 Hs			1 147
+	Hs
		849486 HECD1_HUMAN (1-2610): 0: 2419: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919904 HECD1_HUMAN (1-2610): 0: 2419: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895952 HECD1_HUMAN (1-2610): 0: 2419: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		849351 HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919762 HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895825 HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		919889 HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895935 HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Sc
		549801 UFD4_YEAST (2031-2610): 2.7e-129: 448: 28.16		UBC4_YEAST (3-147): 9.94e-80: 233: 80.69
+	Hs
		304110 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		304101 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		304298 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		304280 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		849416 NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		895887 NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		304080 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		304067 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		UBE2A_HUMAN (2-144): 4.45e-71: 211: 41.26
+	Hs
		304114 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		UBE2B_HUMAN (2-144): 2.02e-70: 210: 39.86
+	Hs
		851875 NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		896522 NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53