HitPredict

Interactor 1: UBE2C (O00762)
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Gene: UBE2C

Interactor 2: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	19250909, 11807090, 30097011, 36563856, 17597759
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process and 1 others more... GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 179 Hs			1 1058
+	Hs
		607050 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607190 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607026 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607136 UB2E2_HUMAN (2-175): 2.69e-78: 233: 33.52		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607039 UB2D3_HUMAN (31-176): 2.12e-78: 231: 34.93		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607129 UB2E3_HUMAN (6-175): 6.95e-77: 230: 34.71		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607028 UB2E1_HUMAN (5-175): 5.46e-75: 224: 32.18		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607023 UBE2A_HUMAN (28-175): 1.29e-69: 209: 40.27		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607054 UBE2B_HUMAN (28-174): 1.23e-68: 207: 41.22		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Sp
		293848 UBC4_SCHPO (31-175): 4.92e-78: 230: 37.24		UBA1_SCHPO (36-1053): 0: 1080: 53.37
+	Sp
		116508 UBC11_SCHPO (4-172): 1.86e-71: 215: 54.97		UBA1_SCHPO (36-1053): 0: 1080: 53.37
+	Sc
		549788 UBC4_YEAST (30-175): 2.78e-77: 228: 36.30		UBA1_YEAST (38-1057): 0: 1063: 51.50
+	Hs
		48107 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		UBA6_HUMAN (12-1057): 0: 1037: 41.09
+	Hs
		48104 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		UBA6_HUMAN (12-1057): 0: 1037: 41.09
+	Hs
		48106 UB2D3_HUMAN (31-176): 2.12e-78: 231: 34.93		UBA6_HUMAN (12-1057): 0: 1037: 41.09
+	Hs
		782203 UB2E1_HUMAN (5-175): 5.46e-75: 224: 32.18		UBA7_HUMAN (41-1057): 0: 1006: 46.00
+	Dm
		715098 UBE2N_DROME (33-157): 8.75e-32: 113: 45.60		Q8T0L3_DROME (36-1057): 0: 1108: 59.75
+	Sc
		410211 UBC2_YEAST (30-172): 2.47e-32: 115: 43.75		UBA1_YEAST (38-1057): 0: 1063: 51.50
+	Hs
		1282360 UB2E3_HUMAN (6-175): 6.95e-77: 230: 34.71		SAE2_HUMAN (60-451): 2.55e-88: 299: 17.08
+	Hs
		919796 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		UBA3_HUMAN (847-1018): 1.74e-12: 72.9: 17.13