Protein: PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)

Gene: PK3CA, Pik3ca
Organism: Mus musculus
Interactions: 21
UniProt ID: P42337

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001889 - liver development
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686942

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

9

20

Small-scale

0.961

High

834246

CSK
Tyrosine-protein kinase CSK

1

11

High-throughput

0.646

High

470808

RASN
GTPase NRas

1

20

Small-scale

0.618

High

533372

RRAS
Ras-related protein R-Ras

1

20

Small-scale

0.618

High

746557

RASK
GTPase KRas

1

20

Small-scale

0.618

High

839123

CRKL
Crk-like protein

1

16

High-throughput

0.618

High

839128

RASH
GTPase HRas

1

20

Small-scale

0.618

High

839129

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.590

High

148535

RASM
Ras-related protein M-Ras

1

20

Small-scale

0.553

High

839125

RRAS2
Ras-related protein R-Ras2

1

20

Small-scale

0.553

High

839130

RASE
GTPase ERas

1

20

Small-scale

0.553

High

839133

APC7
Anaphase-promoting complex subunit 7

1

2

High-throughput

0.528

High

431456

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.479

High

772534

IRS1
Insulin receptor substrate 1

1

8

Small-scale

0.479

High

839126

CTNB1
Catenin beta-1

1

6

Small-scale

0.479

High

839131

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

839134

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

5

High-throughput

0.457

High

651488

CBL
E3 ubiquitin-protein ligase CBL

1

8

High-throughput

0.445

High

839124

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

Small-scale

0.445

High

839127

TPOR
Thrombopoietin receptor

1

0

Small-scale

0.249

Low

839132

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025