HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: TBA1B (P68363)
Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]
Gene: TUBA1B

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 451
+	Dm
		356631 PLK4_DROME (6-662): 1.29e-124: 398: 32.09		TBA1_DROME (1-439): 0: 710: 97.49
+	Hs
		1259535 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		TBA1A_HUMAN (1-440): 0: 712: 99.55
+	Hs
		170315 AURKA_HUMAN (9-273): 3.29e-53: 193: 37.74		TBA1C_HUMAN (1-451): 0: 725: 98.00
+	Hs
		920062 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		TBA1A_HUMAN (1-440): 0: 712: 99.55
+	Hs
		1391732 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		TBA1C_HUMAN (1-451): 0: 725: 98.00
+	Ce
		758688 PLK1_CAEEL (12-259): 5.46e-52: 196: 39.92		TBA2_CAEEL (1-439): 0: 704: 88.38
+	Hs
		997082 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		TBA4A_HUMAN (1-450): 0: 716: 96.44
+	Ce
		198247 PLK1_CAEEL (12-259): 5.46e-52: 196: 39.92		O18688_CAEEL (1-439): 0: 700: 87.70
+	Hs
		1259416 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		TBA1A_HUMAN (1-440): 0: 712: 99.55
+	Hs
		169901 AURKA_HUMAN (9-273): 3.29e-53: 193: 37.74		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Hs
		170074 AURKA_HUMAN (9-273): 3.29e-53: 193: 37.74		TBB4B_HUMAN (1-437): 0: 697: 40.96
+	Hs
		457616 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		TBB5_HUMAN (1-439): 0: 699: 41.23