Protein: PLK4
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase SAK)

Gene: PLK4, SAK
Organism: Drosophila melanogaster
Interactions: 90
UniProt ID: O97143

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005814 - centriole

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

356630

PLK4
Serine/threonine-protein kinase PLK4

9

19

Small-scale

0.982

High

356683

Q9VNE4
Asterless

11

11

Small-scale

0.762

High

356636

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

2

9

Small-scale

0.754

High

356674

Q9VDE3
LD08669p

9

10

Small-scale

0.748

High

356638

CCNC
Cyclin-C

1

2

High-throughput

0.656

High

356649

Q7K306
cyclin-dependent kinase

1

12

High-throughput

0.656

High

356664

CYCG
Cyclin G

1

1

High-throughput

0.656

High

356666

Q961D1
Cyclin-K

1

3

High-throughput

0.656

High

356696

SF3B3
Splicing factor 3B subunit 3

1

6

High-throughput

0.656

High

305450

O77430
GEO01111p1

3

7

Small-scale

0.656

High

356703

Q9XZ31
Anastral spindle 2, isoform A

3

2

Small-scale

0.650

High

356641

POLO
Serine/threonine-protein kinase polo

1

16

High-throughput

0.621

High

356663

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

5

High-throughput

0.621

High

356677

Q9VGF9
Aurora kinase

1

17

High-throughput

0.621

High

356702

Q9W418
GH17761p

1

9

Small-scale

0.618

High

356669

Q9I7T8
PAN2-PAN3 deadenylation complex subunit PAN3

1

1

High-throughput

0.590

High

356648

Q7K0V7
LD27656p

1

8

High-throughput

0.587

High

356671

CEG1A
Centaurin-gamma-1A

1

2

High-throughput

0.587

High

356637

SGG
Protein kinase shaggy

1

8

High-throughput

0.575

High

356665

Q960T6
Centrosomal protein 135kDa, isoform A

1

12

High-throughput

0.573

High

356650

Q7PLE9
Ras-related protein Rab-21

1

17

High-throughput

0.555

High

356657

Q8SXN9
polynucleotide adenylyltransferase

1

3

High-throughput

0.555

High

356647

Q5U0Y0
Paired amphipathic helix protein Sin3a

1

6

High-throughput

0.541

High

52749

A1Z743
polynucleotide adenylyltransferase

1

3

High-throughput

0.528

High

356653

Q8MRG8
Ras-related protein Rab-21

1

17

High-throughput

0.528

High

51793

GUS
Protein gustavus

1

12

High-throughput

0.508

High

84283

DIMM
Protein dimmed

1

4

High-throughput

0.508

High

356633

BCD
Homeotic protein bicoid

1

8

High-throughput

0.508

High

356639

ECR
Ecdysone receptor

1

8

High-throughput

0.508

High

356640

ATPA
ATP synthase subunit alpha, mitochondrial

1

5

High-throughput

0.508

High

356643

FTF1B
Nuclear hormone receptor FTZ-F1 beta

1

8

High-throughput

0.508

High

356646

RAD51
DNA repair protein Rad51 homolog

1

1

High-throughput

0.508

High

356668

Q9I7L0
LP01847p

1

2

High-throughput

0.508

High

356675

Q9VFQ3
E5

1

5

High-throughput

0.508

High

356680

Q9VL21
LD11652p

1

8

High-throughput

0.508

High

356688

FRY
Protein furry

1

4

High-throughput

0.508

High

356690

Q9VUD3
GH07353p

1

14

High-throughput

0.508

High

356701

AAAS
Aladin

1

1

High-throughput

0.508

High

356704

MED15
Mediator of RNA polymerase II transcription subunit 15

1

7

High-throughput

0.508

High

356685

Q9VQV7
Centrosomal protein of 97 kDa

1

12

Small-scale

0.501

High

356691

Q9VV79
BcDNA.LD24702

1

1

Small-scale

0.501

High

356631

TBA1
Tubulin alpha-1 chain

1

11

Small-scale

0.500

High

356634

HSP7D
Heat shock 70 kDa protein cognate 4

1

3

Small-scale

0.500

High

356645

TBB1
Tubulin beta-1 chain

1

9

Small-scale

0.500

High

356661

Q8T965
Prefoldin subunit 3

1

0

High-throughput

0.486

High

356681

Q9VL27
Alpha-galactosidase

1

0

High-throughput

0.486

High

85009

B7Z143
Protein interacting with Ttk69 and Sin3A, isoform D

1

1

High-throughput

0.481

High

122297

M9PI43
Centriolar coiled coil protein 110kDa, isoform F

1

1

High-throughput

0.481

High

356652

PANG2
Protein pangolin, isoform J

1

11

High-throughput

0.481

High

356667

Q961D7
LD07765p

1

2

High-throughput

0.481

High

356684

Q9VQ95
Testis EndoG-Like 3

1

1

High-throughput

0.481

High

356698

Q9W1H7
Putative homeodomain protein

1

1

High-throughput

0.481

High

356644

CUL1
Cullin homolog 1

1

8

Small-scale

0.479

High

356660

ENA
Protein enabled

1

5

High-throughput

0.464

High

356676

Q9VG22
Davis-cup

1

20

High-throughput

0.464

High

356682

POLZ2
DNA polymerase zeta subunit 2

1

2

High-throughput

0.464

High

356686

Q9VRQ4
LD47944p

1

1

High-throughput

0.464

High

356687

Q9VS41
Unc-13-4A, isoform B

1

2

High-throughput

0.464

High

356697

Q9W0Y0
RE57840p

1

3

High-throughput

0.464

High

303717

O76136
Homeodomain protein

1

2

High-throughput

0.457

High

356654

Q8MS22
RE41430p

1

1

High-throughput

0.457

High

356695

Q9VZU6
BTB-VII protein domain

1

5

High-throughput

0.457

High

262709

TENM
Teneurin-m

1

3

High-throughput

0.445

High

356632

TBB3
Tubulin beta-3 chain

1

9

Small-scale

0.445

High

356678

Q9VH81
protein-serine/threonine phosphatase

1

17

High-throughput

0.445

High

51846

A1Z6E8
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

95617

E3CTS2
MIP27658p

1

1

High-throughput

0.439

High

121527

M9PFH3
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

356651

Q7Z2C5
Uncharacterized protein

1

4

High-throughput

0.439

High

356672

Q9VAZ0
FI05230p

1

1

High-throughput

0.439

High

356642

PANG1
Protein pangolin, isoforms A/H/I/S

1

10

High-throughput

0.417

High

356655

Q8MSW5
LD24928p

1

1

High-throughput

0.417

High

356658

Q8SYU4
RE33778p

1

1

High-throughput

0.417

High

356662

Q95RL9
LD20432p

1

1

High-throughput

0.417

High

356689

Q9VU23
Uncharacterized protein, isoform E

1

1

High-throughput

0.417

High

356693

Q9VYF9
RE28286p

1

7

High-throughput

0.417

High

356673

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.282

High

234818

O46070
EG:25E8.4 protein

1

0

High-throughput

0.265

Low

234922

PGAM5
Serine/threonine-protein phosphatase Pgam5, mitochondrial

1

0

High-throughput

0.265

Low

356635

VTU2
Vitelline membrane protein Vm26Ab

1

0

High-throughput

0.265

Low

356656

Q8SXL5
RE09177p

1

0

High-throughput

0.265

Low

356659

Q8SZP2
RE71854p

1

0

High-throughput

0.265

Low

356670

Q9I7Z8
LD21943p

1

0

High-throughput

0.265

Low

356679

PPT2
Lysosomal thioesterase PPT2 homolog

1

0

High-throughput

0.265

Low

356692

Q9VWT7
GEO07745p1

1

0

High-throughput

0.265

Low

356694

Q9VZG2
Cuticular protein 64Aa

1

0

High-throughput

0.265

Low

356699

Q9W1P1
Cilia- and flagella-associated protein 61 N-terminal domain-containing protein

1

0

High-throughput

0.265

Low

356700

Q9W221
MIP04282p

1

0

High-throughput

0.265

Low

53297

A1Z7M3
Notopleural, isoform A

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025