Protein: PLK2
Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase)

Gene: PLK2
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q9NYY3

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000776 - kinetochore
GO:0000785 - chromatin
GO:0000922 - spindle pole
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177318

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

3

7

High-throughput

0.861

High

1097238

PAK2
Serine/threonine-protein kinase PAK 2

3

17

High-throughput

0.861

High

1331015

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

3

7

High-throughput

0.770

High

1050718

DYN1
Dynamin-1

1

5

Small-scale

0.724

High

168759

CSKP
Peripheral plasma membrane protein CASK

1

20

High-throughput

0.698

High

531162

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

9

High-throughput

0.691

High

1256807

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

17

High-throughput

0.691

High

289287

SPB7
Serpin B7

3

3

High-throughput

0.667

High

1338078

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

3

1

High-throughput

0.667

High

920315

PLK1
Serine/threonine-protein kinase PLK1

1

17

Small-scale

0.666

High

791779

SYUA
Alpha-synuclein

3

5

Small-scale

0.651

High

1431048

RNAS7
Ribonuclease 7

3

0

High-throughput

0.638

High

896905

DYN2
Dynamin-2

1

5

Small-scale

0.618

High

1407518

CIB1
Calcium and integrin-binding protein 1

1

20

Small-scale

0.618

High

1452847

DYN3
Dynamin-3

1

5

Small-scale

0.618

High

261667

CATL2
Cathepsin L2

3

1

High-throughput

0.609

High

1309625

SPA12
Serpin A12

3

3

High-throughput

0.609

High

1311566

SUGP1
SURP and G-patch domain-containing protein 1

3

1

High-throughput

0.609

High

1452846

CBPA4
Carboxypeptidase A4

3

2

High-throughput

0.609

High

1051877

EF1A2
Elongation factor 1-alpha 2

2

0

High-throughput

0.585

High

1191616

RABL6
Rab-like protein 6

2

0

High-throughput

0.585

High

1281052

TAF8
Transcription initiation factor TFIID subunit 8

2

0

High-throughput

0.585

High

857191

NSF
Vesicle-fusing ATPase

1

8

Small-scale

0.573

High

1294648

CD20B
Cell division cycle protein 20 homolog B

1

9

High-throughput

0.573

High

344813

AP2A1
AP-2 complex subunit alpha-1

1

6

Small-scale

0.561

High

1083326

AP1B1
AP-1 complex subunit beta-1

1

6

Small-scale

0.561

High

1365012

TSC1
Hamartin

1

9

Small-scale

0.561

High

369404

A1AT
Alpha-1-antitrypsin

2

3

High-throughput

0.558

High

502152

H2AZ
Histone H2A.Z

1

10

High-throughput

0.536

High

1129049

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

5

High-throughput

0.536

High

1162910

H2A2C
Histone H2A type 2-C

1

6

High-throughput

0.536

High

1286270

PCGF5
Polycomb group RING finger protein 5

1

7

High-throughput

0.536

High

1362114

IRGQ
Immunity-related GTPase family Q protein

1

3

High-throughput

0.536

High

1365604

MY18A
Unconventional myosin-XVIIIa

1

2

High-throughput

0.536

High

1418702

LOXE3
Hydroperoxide isomerase ALOXE3

1

3

High-throughput

0.536

High

1452849

TR150
Thyroid hormone receptor-associated protein 3

1

6

High-throughput

0.536

High

874008

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.518

High

567750

HEM2
Delta-aminolevulinic acid dehydratase

1

0

High-throughput

0.513

High

1430796

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.513

High

225859

AP1G1
AP-1 complex subunit gamma-1

1

6

Small-scale

0.501

High

423330

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

861812

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

High-throughput

0.501

High

890898

TSC2
Tuberin

1

3

Small-scale

0.501

High

1259535

TBA1A
Tubulin alpha-1A chain

1

5

Small-scale

0.501

High

1103528

MPP3
MAGUK p55 subfamily member 3

1

11

High-throughput

0.494

High

50834

CA226
Uncharacterized protein C1orf226

1

1

High-throughput

0.489

High

1309743

MFN1
Mitofusin-1

1

1

High-throughput

0.489

High

1359814

RT4I1
NAD(P)H oxidoreductase RTN4IP1, mitochondrial

1

1

High-throughput

0.489

High

1452845

CATZ
Cathepsin Z

1

4

High-throughput

0.489

High

135720

DNM1L
Dynamin-1-like protein

1

5

Small-scale

0.479

High

173470

XPO1
Exportin-1

1

9

High-throughput

0.479

High

730923

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

900196

FXR1
RNA-binding protein FXR1

1

12

High-throughput

0.479

High

972069

1433E
14-3-3 protein epsilon

1

14

High-throughput

0.479

High

992359

SKP1
S-phase kinase-associated protein 1

1

5

Small-scale

0.479

High

1005179

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1380210

FBXW7
F-box/WD repeat-containing protein 7

1

9

Small-scale

0.479

High

1452850

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.479

High

258193

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

1026253

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.458

High

116541

H7C4S4
FMR1 autosomal homolog 1

1

7

High-throughput

0.445

High

1438725

CPAP
Centrosomal P4.1-associated protein

1

6

Small-scale

0.445

High

327657

ELP1
Elongator complex protein 1

1

0

High-throughput

0.438

High

892142

KLK7
Kallikrein-7

1

2

High-throughput

0.437

High

1050311

CSTF1
Cleavage stimulation factor subunit 1

1

5

High-throughput

0.437

High

1452848

DLGP4
Disks large-associated protein 4

1

3

High-throughput

0.417

High

1259034

CENPU
Centromere protein U

1

2

Small-scale

0.408

High

379143

IGKC
Immunoglobulin kappa constant

1

1

High-throughput

0.407

High

1358592

POF1B
Protein POF1B

3

0

High-throughput

0.347

High

1385266

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.279

Low

1287065

RN180
E3 ubiquitin-protein ligase RNF180

1

0

Small-scale

0.249

Low

1356577

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025