HitPredict

Interactor 1: Q9VBI1 (Q9VBI1)
DNA replication complex GINS protein SLD5
Gene: Sld5

Interactor 2: MCM3 (Q9XYU1)
DNA replication licensing factor Mcm3 (EC 3.6.4.12) (Minichromosome maintenance 3 protein) (DmMCM3)
Gene: MCM3

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25117490, 21378962
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MCM~Sld5, MCM_N~Sld5
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0071162 - CMG complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 228 Dm			1 819
+	Mm
		627416 SLD5_MOUSE (15-228): 7.59e-79: 237: 37.56		MCM3_MOUSE (5-819): 0: 889: 60.32
+	Hs
		627346 SLD5_HUMAN (15-228): 1.1e-76: 232: 37.56		MCM3_HUMAN (5-819): 0: 880: 61.54
+	Mm
		956197 SLD5_MOUSE (15-228): 7.59e-79: 237: 37.56		MCM2_MOUSE (11-723): 0: 721: 31.67
+	Hs
		832679 SLD5_HUMAN (15-228): 1.1e-76: 232: 37.56		MCM2_HUMAN (11-723): 0: 719: 31.95
+	Dm
		832227 Q9VBI1_DROME (1-228): 6.79e-89: 263: 100.00		MCM2_DROME (11-722): 0: 686: 30.19
+	Hs
		708751 SLD5_HUMAN (15-228): 1.1e-76: 232: 37.56		MCM5_HUMAN (2-702): 0: 699: 28.94
+	Dm
		1361990 Q9VBI1_DROME (1-228): 6.79e-89: 263: 100.00		MCM5_DROME (7-727): 0: 666: 29.70
+	Mm
		956209 SLD5_MOUSE (15-228): 7.59e-79: 237: 37.56		MCM6_MOUSE (6-756): 0: 688: 25.25
+	Hs
		709029 SLD5_HUMAN (15-228): 1.1e-76: 232: 37.56		MCM7_HUMAN (5-665): 0: 688: 32.79
+	Mm
		1143182 SLD5_MOUSE (15-228): 7.59e-79: 237: 37.56		MCM7_MOUSE (5-665): 0: 681: 32.35
+	Dm
		1099472 Q9VBI1_DROME (1-228): 6.79e-89: 263: 100.00		MCM4_DROME (6-738): 0: 651: 26.21
+	Hs
		1055616 SLD5_HUMAN (15-228): 1.1e-76: 232: 37.56		MCM6_HUMAN (6-756): 0: 678: 24.88
+	Sc
		622191 SLD5_YEAST (24-228): 5.76e-64: 202: 20.40		MCM3_YEAST (42-819): 0: 691: 41.22
+	Hs
		708503 SLD5_HUMAN (15-228): 1.1e-76: 232: 37.56		MCM4_HUMAN (6-657): 0: 642: 28.78
+	Sc
		667627 SLD5_YEAST (24-228): 5.76e-64: 202: 20.40		MCM2_YEAST (8-650): 0: 663: 31.76
+	Sc
		667884 SLD5_YEAST (24-228): 5.76e-64: 202: 20.40		MCM5_YEAST (111-644): 7.01e-91: 305: 35.36
+	Sc
		744790 SLD5_YEAST (24-228): 5.76e-64: 202: 20.40		MCM7_YEAST (105-646): 4.01e-86: 293: 36.87