HitPredict

Interactor 1: MACD1 (Q922B1)
ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
Gene: Macrod1

Interactor 2: MACD1 (Q922B1)
ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
Gene: Macrod1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

The method score is based on:

Property	Details
Experiments	29199018, 29222160, 28130547
Identification Methods	cross-linking study
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Macro~Macro
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005739 - mitochondrion GO:0006974 - DNA damage response GO:0016798 - hydrolase activity, acting on glycosyl bonds and 5 others more... GO:0042278 - purine nucleoside metabolic process GO:0051725 - protein de-ADP-ribosylation GO:0061463 - O-acetyl-ADP-ribose deacetylase activity GO:0140291 - peptidyl-glutamate ADP-deribosylation GO:0140293 - ADP-ribosylglutamate hydrolase activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	323
Mm

1	323

Service provided by Combinatics, Japan

Last updated: 11Aug2025