HitPredict

Interactor 1: THIOM (Q99757)
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
Gene: TXN2

Interactor 2: TXNIP (Q9H3M7)
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Gene: TXNIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	28514442, 33961781, 30733849
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arrestin_C~Thioredoxin
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 166 Hs			1 391
+	Hs
		1142392 PDIA6_HUMAN (62-165): 1.98e-33: 123: 23.81		TXNIP_HUMAN (1-391): 1.41e-149: 430: 100.00
+	Hs
		528349 THIO_HUMAN (61-165): 2.15e-36: 123: 35.85		TXNIP_HUMAN (1-391): 1.41e-149: 430: 100.00
+	Dm
		1440251 THIO2_DROME (61-162): 1.78e-36: 123: 36.89		Q9I7K7_DROME (9-382): 2.02e-75: 241: 15.73
+	Hs
		452180 PDIA1_HUMAN (27-163): 8.24e-33: 123: 21.99		ARRB2_HUMAN (15-323): 2.03e-60: 202: 12.18
+	Hs
		452197 PDIA1_HUMAN (27-163): 8.24e-33: 123: 21.99		ARRB1_HUMAN (25-358): 2.61e-56: 191: 12.95
+	Rn
		539761 THIO_RAT (64-164): 2.35e-35: 120: 36.28		ARRB1_RAT (25-313): 6.74e-56: 191: 12.61