Protein: TXNIP
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)

Gene: TXNIP
Organism: Homo sapiens
Interactions: 214
UniProt ID: Q9H3M7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0004857 - enzyme inhibitor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006606 - protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

528349

THIO
Thioredoxin

22

6

Small-scale

0.990

High

1407195

THIOM
Thioredoxin, mitochondrial

3

6

Small-scale

0.770

High

1432710

TXNIP
Thioredoxin-interacting protein

2

13

Small-scale

0.754

High

1394610

ITCH
E3 ubiquitin-protein ligase Itchy homolog

7

20

Small-scale

0.752

High

1430204

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

7

20

Small-scale

0.747

High

1399388

NLRP3
NACHT, LRR and PYD domains-containing protein 3

6

1

Small-scale

0.721

High

538684

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

4

9

Small-scale

0.680

High

132293

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

20

Small-scale

0.667

High

1102651

MTA1
Metastasis-associated protein MTA1

3

3

Small-scale

0.667

High

1110073

HDAC1
Histone deacetylase 1

3

5

Small-scale

0.664

High

557469

SRC
Proto-oncogene tyrosine-protein kinase Src

1

7

Small-scale

0.647

High

1053745

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

4

Small-scale

0.639

High

1361009

P66B
Transcriptional repressor p66-beta

3

0

Small-scale

0.638

High

193818

PER1
Period circadian protein homolog 1

2

3

High-throughput

0.628

High

288014

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

4

High-throughput

0.628

High

1290301

KBTB6
Kelch repeat and BTB domain-containing protein 6

2

7

High-throughput

0.628

High

1358854

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

7

High-throughput

0.628

High

1432714

RAD18
E3 ubiquitin-protein ligase RAD18

2

2

High-throughput

0.628

High

351167

ECD
Protein ecdysoneless homolog

2

0

Small-scale

0.625

High

1368116

HDAC2
Histone deacetylase 2

2

5

Small-scale

0.621

High

215349

TXNL1
Thioredoxin-like protein 1

1

7

Small-scale

0.618

High

853524

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

2

5

Small-scale

0.611

High

856919

BAG6
Large proline-rich protein BAG6

2

20

Small-scale

0.611

High

933729

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

4

Small-scale

0.611

High

1280493

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

20

Small-scale

0.611

High

841583

I12R1
Interleukin-12 receptor subunit beta-1

3

5

High-throughput

0.609

High

352244

MBD3
Methyl-CpG-binding domain protein 3

2

0

High-throughput

0.602

High

1193567

CRY2
Cryptochrome-2

2

0

High-throughput

0.602

High

1432728

RUVB2
RuvB-like 2

2

4

Small-scale

0.586

High

414612

P53
Cellular tumor antigen p53

2

3

Small-scale

0.584

High

537899

HSP7C
Heat shock cognate 71 kDa protein

2

4

Small-scale

0.584

High

637729

FLNA
Filamin-A

2

7

Small-scale

0.584

High

1161393

HIF1A
Hypoxia-inducible factor 1-alpha

2

2

Small-scale

0.584

High

1432736

TRAF6
TNF receptor-associated factor 6

1

9

Small-scale

0.578

High

1225970

F91A1
Protein FAM91A1

2

1

High-throughput

0.574

High

326034

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.561

High

1432738

TF3C3
General transcription factor 3C polypeptide 3

2

3

Small-scale

0.558

High

1142392

PDIA6
Protein disulfide-isomerase A6

1

6

Small-scale

0.553

High

1432733

ZBT32
Zinc finger and BTB domain-containing protein 32

1

1

Small-scale

0.552

High

1432718

DDIT4
DNA damage-inducible transcript 4 protein

1

0

Small-scale

0.537

High

913677

VAV2
Guanine nucleotide exchange factor VAV2

1

4

Small-scale

0.536

High

67505

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

1

High-throughput

0.536

High

208565

PJA2
E3 ubiquitin-protein ligase Praja-2

1

6

High-throughput

0.536

High

291958

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

5

High-throughput

0.536

High

343051

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.536

High

407710

S100B
Protein S100-B

1

5

High-throughput

0.536

High

667448

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

6

High-throughput

0.536

High

686865

S10A4
Protein S100-A4

1

5

High-throughput

0.536

High

697655

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.536

High

701227

PSB5
Proteasome subunit beta type-5

1

7

High-throughput

0.536

High

861288

MAP1B
Microtubule-associated protein 1B

1

17

High-throughput

0.536

High

1094813

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.536

High

1122341

SCRIB
Protein scribble homolog

1

4

High-throughput

0.536

High

1159001

RBBP7
Histone-binding protein RBBP7

1

2

High-throughput

0.536

High

1220137

PAPD7
Terminal nucleotidyltransferase 4A

1

3

High-throughput

0.536

High

1243046

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.536

High

1272431

GET4
Golgi to ER traffic protein 4 homolog

1

3

High-throughput

0.536

High

1278274

NPHP3
Nephrocystin-3

1

2

High-throughput

0.536

High

1339847

PJA1
E3 ubiquitin-protein ligase Praja-1

1

5

High-throughput

0.536

High

1394954

MAGD4
Melanoma-associated antigen D4

1

4

High-throughput

0.536

High

1396897

KI16B
Kinesin-like protein KIF16B

1

3

High-throughput

0.536

High

1400016

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

High-throughput

0.536

High

1404579

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

5

High-throughput

0.536

High

1406567

METH
Methionine synthase

1

1

High-throughput

0.536

High

1419909

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.536

High

1420807

ZCHC2
Zinc finger CCHC domain-containing protein 2

1

2

High-throughput

0.536

High

1432717

RNF12
E3 ubiquitin-protein ligase RLIM

1

6

High-throughput

0.536

High

1432730

E41L3
Band 4.1-like protein 3

1

8

High-throughput

0.536

High

1432734

DCAF1
DDB1- and CUL4-associated factor 1

1

6

High-throughput

0.536

High

239207

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

833778

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

1156328

HSPB2
Heat shock protein beta-2

1

4

High-throughput

0.508

High

1432712

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

20

High-throughput

0.508

High

188364

HDAC3
Histone deacetylase 3

1

5

Small-scale

0.501

High

703704

MK01
Mitogen-activated protein kinase 1

1

6

Small-scale

0.501

High

1095456

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

4

Small-scale

0.501

High

282084

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.489

High

1083748

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.489

High

1147566

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.489

High

1251867

SCAR5
Scavenger receptor class A member 5

1

5

High-throughput

0.489

High

1398837

DOCK7
Dedicator of cytokinesis protein 7

1

2

High-throughput

0.489

High

1402712

TCPQM
T-complex protein 1 subunit theta-like 2

1

2

High-throughput

0.489

High

1116451

FHL1
Four and a half LIM domains protein 1

1

0

High-throughput

0.486

High

409081

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.481

High

996336

EF1A1
Elongation factor 1-alpha 1

1

3

Small-scale

0.481

High

1432715

INT9
Integrator complex subunit 9

1

2

Small-scale

0.481

High

172214

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

10

Small-scale

0.479

High

173351

XPO1
Exportin-1

1

10

Small-scale

0.479

High

212328

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

Small-scale

0.479

High

246944

KDM1A
Lysine-specific histone demethylase 1A

1

4

Small-scale

0.479

High

334100

SMC2
Structural maintenance of chromosomes protein 2

1

4

Small-scale

0.479

High

334904

IPO7
Importin-7

1

12

Small-scale

0.479

High

344016

HS74L
Heat shock 70 kDa protein 4L

1

8

Small-scale

0.479

High

344790

AP2A1
AP-2 complex subunit alpha-1

1

12

Small-scale

0.479

High

363847

EGFR
Epidermal growth factor receptor

1

9

Small-scale

0.479

High

417750

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

Small-scale

0.479

High

420691

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.479

High

457692

TBB5
Tubulin beta chain

1

9

Small-scale

0.479

High

461927

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

468797

HS90B
Heat shock protein HSP 90-beta

1

4

Small-scale

0.479

High

487747

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.479

High

547690

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

Small-scale

0.479

High

552878

TPR
Nucleoprotein TPR

1

7

Small-scale

0.479

High

568291

PLST
Plastin-3

1

5

Small-scale

0.479

High

573669

ENPL
Endoplasmin

1

4

Small-scale

0.479

High

608190

PYRG1
CTP synthase 1

1

1

Small-scale

0.479

High

631470

RAB5A
Ras-related protein Rab-5A

1

2

Small-scale

0.479

High

635636

FILA
Filaggrin

1

13

Small-scale

0.479

High

660726

IF4B
Eukaryotic translation initiation factor 4B

1

7

Small-scale

0.479

High

681026

PSA1
Proteasome subunit alpha type-1

1

2

Small-scale

0.479

High

681228

PSA2
Proteasome subunit alpha type-2

1

3

Small-scale

0.479

High

700733

PSA5
Proteasome subunit alpha type-5

1

3

Small-scale

0.479

High

717995

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

12

Small-scale

0.479

High

731611

STIP1
Stress-induced-phosphoprotein 1

1

2

Small-scale

0.479

High

761872

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.479

High

778781

PRS7
26S proteasome regulatory subunit 7

1

6

Small-scale

0.479

High

839084

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

12

Small-scale

0.479

High

876724

HSP13
Heat shock 70 kDa protein 13

1

11

Small-scale

0.479

High

922034

COPA
Coatomer subunit alpha

1

2

Small-scale

0.479

High

930792

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

4

Small-scale

0.479

High

933354

IF5
Eukaryotic translation initiation factor 5

1

1

Small-scale

0.479

High

954268

RS20
Small ribosomal subunit protein uS10

1

1

Small-scale

0.479

High

987473

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

15

Small-scale

0.479

High

992960

RACK1
Small ribosomal subunit protein RACK1

1

6

Small-scale

0.479

High

997508

TBB4B
Tubulin beta-4B chain

1

9

Small-scale

0.479

High

998021

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.479

High

1007279

TCPB
T-complex protein 1 subunit beta

1

2

Small-scale

0.479

High

1023168

RBM10
RNA-binding protein 10

1

7

Small-scale

0.479

High

1045762

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

1066776

NCBP1
Nuclear cap-binding protein subunit 1

1

4

Small-scale

0.479

High

1068307

AHNK
Neuroblast differentiation-associated protein AHNAK

1

4

Small-scale

0.479

High

1085619

FOXO1
Forkhead box protein O1

1

1

Small-scale

0.479

High

1100371

TIF1B
Transcription intermediary factor 1-beta

1

7

Small-scale

0.479

High

1108703

TBB3
Tubulin beta-3 chain

1

9

Small-scale

0.479

High

1115424

CUL4B
Cullin-4B

1

5

Small-scale

0.479

High

1124718

SRC8
Src substrate cortactin

1

13

Small-scale

0.479

High

1134380

IMB1
Importin subunit beta-1

1

20

Small-scale

0.479

High

1134721

NUMA1
Nuclear mitotic apparatus protein 1

1

7

Small-scale

0.479

High

1137154

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

16

Small-scale

0.479

High

1144310

STK38
Serine/threonine-protein kinase 38

1

10

Small-scale

0.479

High

1164307

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

7

Small-scale

0.479

High

1204799

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

6

Small-scale

0.479

High

1212851

UBR4
E3 ubiquitin-protein ligase UBR4

1

7

Small-scale

0.479

High

1216050

TTBK1
Tau-tubulin kinase 1

1

12

Small-scale

0.479

High

1247893

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

1

Small-scale

0.479

High

1259498

TBA1A
Tubulin alpha-1A chain

1

12

Small-scale

0.479

High

1275672

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

Small-scale

0.479

High

1295211

HOME1
Homer protein homolog 1

1

1

Small-scale

0.479

High

1295718

HORN
Hornerin

1

12

Small-scale

0.479

High

1367260

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1370371

CSN5
COP9 signalosome complex subunit 5

1

1

Small-scale

0.479

High

1371527

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

Small-scale

0.479

High

1380160

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1405851

DNJC7
DnaJ homolog subfamily C member 7

1

2

Small-scale

0.479

High

1410590

TBA1C
Tubulin alpha-1C chain

1

12

Small-scale

0.479

High

1414188

TBB6
Tubulin beta-6 chain

1

9

Small-scale

0.479

High

1419689

GTPB4
GTP-binding protein 4

1

4

Small-scale

0.479

High

1420925

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

9

Small-scale

0.479

High

1432721

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

7

Small-scale

0.479

High

1432724

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

Small-scale

0.479

High

1432725

YETS2
YEATS domain-containing protein 2

1

4

Small-scale

0.479

High

1432726

MAGD2
Melanoma-associated antigen D2

1

4

Small-scale

0.479

High

1432729

RUVB1
RuvB-like 1

1

4

Small-scale

0.479

High

1432732

NOP58
Nucleolar protein 58

1

5

Small-scale

0.479

High

703378

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

5

High-throughput

0.470

High

1432720

NLGN3
Neuroligin-3

1

1

Small-scale

0.464

High

186269

SIVA
Apoptosis regulatory protein Siva

1

0

Small-scale

0.460

High

328451

SCEL
Sciellin

1

0

Small-scale

0.460

High

1119113

IDI1
Isopentenyl-diphosphate Delta-isomerase 1

1

0

Small-scale

0.460

High

1432713

CBX8
Chromobox protein homolog 8

1

0

Small-scale

0.460

High

1432722

UXT
Protein UXT

1

0

Small-scale

0.460

High

259102

DNJA2
DnaJ homolog subfamily A member 2

1

0

Small-scale

0.458

High

551257

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

822863

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

857360

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

Small-scale

0.458

High

892942

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

1005962

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

1051422

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

Small-scale

0.458

High

1240695

CDC73
Parafibromin

1

0

Small-scale

0.458

High

1286794

KAISO
Transcriptional regulator Kaiso

1

0

Small-scale

0.458

High

1432711

STEEP
STING ER exit protein

1

0

Small-scale

0.458

High

1432731

RRP44
Exosome complex exonuclease RRP44

1

0

Small-scale

0.458

High

574118

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

9

High-throughput

0.445

High

839505

PI4KA
Phosphatidylinositol 4-kinase alpha

1

14

High-throughput

0.445

High

330508

LC7L3
Luc7-like protein 3

1

4

Small-scale

0.439

High

552389

ADT3
ADP/ATP translocase 3

1

1

Small-scale

0.437

High

670007

MCM3
DNA replication licensing factor MCM3

1

7

Small-scale

0.437

High

756345

MCM7
DNA replication licensing factor MCM7

1

4

Small-scale

0.437

High

778102

VGFR2
Vascular endothelial growth factor receptor 2

1

5

Small-scale

0.437

High

1004405

NOP14
Nucleolar protein 14

1

4

Small-scale

0.437

High

1005502

RBM6
RNA-binding protein 6

1

10

Small-scale

0.437

High

1010715

DCD
Dermcidin

1

1

Small-scale

0.437

High

1195692

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

13

High-throughput

0.437

High

1270783

DDX46
Probable ATP-dependent RNA helicase DDX46

1

2

Small-scale

0.437

High

1359917

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

5

Small-scale

0.437

High

1432716

ATD3A
ATPase family AAA domain-containing protein 3A

1

5

Small-scale

0.437

High

538853

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

9

High-throughput

0.407

High

1359701

PHIP
PH-interacting protein

1

3

High-throughput

0.407

High

1432719

DCA16
DDB1- and CUL4-associated factor 16

2

0

High-throughput

0.328

High

1085831

TF3C1
General transcription factor 3C polypeptide 1

1

0

High-throughput

0.279

Low

1229506

C19L1
CWF19-like protein 1

1

0

High-throughput

0.279

Low

1384204

RGMA
Repulsive guidance molecule A

1

0

High-throughput

0.279

Low

1395406

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.279

Low

273001

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

Small-scale

0.249

Low

318536

TOX4
TOX high mobility group box family member 4

1

0

Small-scale

0.249

Low

467607

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.249

Low

1090047

IRAG2
Inositol 1,4,5-triphosphate receptor associated 2

1

0

Small-scale

0.249

Low

1151461

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

Small-scale

0.249

Low

1432088

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

Small-scale

0.249

Low

1432723

S30BP
SAP30-binding protein

1

0

Small-scale

0.249

Low

1432727

SCML2
Sex comb on midleg-like protein 2

1

0

Small-scale

0.249

Low

1432735

TCAF1
TRPM8 channel-associated factor 1

1

0

Small-scale

0.249

Low

1432737

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025