HitPredict

Interactor 1: SIN1 (Q9BPZ7)
Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1)
Gene: MAPKAP1

Interactor 2: LST8 (Q9BVC4)
Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)
Gene: MLST8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

The method score is based on:

Property	Details
Experiments	29567957, 28489822, 37688978, 16919458, 17461779
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	CRIM~WD40, SIN1~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0007010 - cytoskeleton organization and 6 others more... GO:0030307 - positive regulation of cell growth GO:0031669 - cellular response to nutrient levels GO:0031932 - TORC2 complex GO:0038203 - TORC2 signaling GO:0043066 - negative regulation of apoptotic process GO:1902554 - serine/threonine protein kinase complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	522
Hs

1	326

Service provided by Combinatics, Japan

Last updated: 11Aug2025