Protein: SIN1
Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1)

Gene: SIN1, MAPKAP1
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q9BPZ7

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1246953

RICTR
Rapamycin-insensitive companion of mTOR

26

2

Small-scale

0.992

High

839351

MTOR
Serine/threonine-protein kinase mTOR

23

5

Small-scale

0.989

High

1409781

LST8
Target of rapamycin complex subunit LST8

5

3

Small-scale

0.906

High

375883

RASK
GTPase KRas

2

1

High-throughput

0.754

High

374162

RASN
GTPase NRas

1

1

High-throughput

0.747

High

728404

AKT1
RAC-alpha serine/threonine-protein kinase

6

5

Small-scale

0.735

High

966806

1433G
14-3-3 protein gamma

5

7

High-throughput

0.716

High

730194

1433B
14-3-3 protein beta/alpha

5

7

High-throughput

0.714

High

1049718

1433F
14-3-3 protein eta

3

7

High-throughput

0.662

High

1008312

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

Small-scale

0.646

High

990663

1433Z
14-3-3 protein zeta/delta

2

7

High-throughput

0.628

High

126767

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.618

High

601422

RHOQ
Rho-related GTP-binding protein RhoQ

1

2

High-throughput

0.618

High

1015717

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.618

High

1151844

RHOH
Rho-related GTP-binding protein RhoH

1

2

High-throughput

0.618

High

1270963

RHOU
Rho-related GTP-binding protein RhoU

1

4

High-throughput

0.618

High

1396620

RHOV
Rho-related GTP-binding protein RhoV

1

4

High-throughput

0.618

High

1409786

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.618

High

1409788

RHOF
Rho-related GTP-binding protein RhoF

1

3

High-throughput

0.618

High

920236

PLK1
Serine/threonine-protein kinase PLK1

2

1

High-throughput

0.611

High

1236093

PRR5L
Proline-rich protein 5-like

2

1

Small-scale

0.611

High

603352

KPCA
Protein kinase C alpha type

2

4

Small-scale

0.606

High

691375

1433T
14-3-3 protein theta

2

7

High-throughput

0.601

High

799440

BRCA1
Breast cancer type 1 susceptibility protein

2

0

Small-scale

0.593

High

965193

WDR5
WD repeat-containing protein 5

2

0

Small-scale

0.585

High

853730

MK08
Mitogen-activated protein kinase 8

1

2

Small-scale

0.578

High

1409812

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

0

High-throughput

0.576

High

396811

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1017558

PRR5
Proline-rich protein 5

1

1

Small-scale

0.554

High

971933

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.536

High

979172

RS6
Small ribosomal subunit protein eS6

1

1

Small-scale

0.536

High

1144304

STK38
Serine/threonine-protein kinase 38

1

4

Small-scale

0.536

High

467293

MDR1
ATP-dependent translocase ABCB1

1

0

High-throughput

0.518

High

1025837

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.518

High

1409803

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.517

High

730857

1433S
14-3-3 protein sigma

1

7

High-throughput

0.515

High

1035017

KPCE
Protein kinase C epsilon type

1

2

Small-scale

0.515

High

911951

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.513

High

1243850

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.513

High

1382519

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

1409782

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

0

High-throughput

0.513

High

1409787

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1409810

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.513

High

122975

SGK1
Serine/threonine-protein kinase Sgk1

1

5

Small-scale

0.501

High

508520

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

170314

AURKA
Aurora kinase A

1

4

Small-scale

0.479

High

173278

XPO1
Exportin-1

1

1

High-throughput

0.479

High

176872

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.479

High

208724

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.479

High

230564

KIF1C
Kinesin-like protein KIF1C

1

1

High-throughput

0.479

High

245263

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

4

High-throughput

0.479

High

281400

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.479

High

622671

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

Small-scale

0.479

High

630343

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

Small-scale

0.479

High

637944

NF1
Neurofibromin

1

1

High-throughput

0.479

High

719261

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719365

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

890881

TSC2
Tuberin

1

1

Small-scale

0.479

High

981940

RL23
Large ribosomal subunit protein uL14

1

1

Small-scale

0.479

High

984255

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

1025587

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

1114126

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1115384

CUL4B
Cullin-4B

1

1

Small-scale

0.479

High

1158170

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.479

High

1161203

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.479

High

1216085

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.479

High

1219613

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1251420

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.479

High

1309241

KSR1
Kinase suppressor of Ras 1

1

1

High-throughput

0.479

High

1349472

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1352603

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.479

High

1367120

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1391729

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1396781

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

1409778

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1409783

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

Small-scale

0.479

High

1409790

KI13B
Kinesin-like protein KIF13B

1

1

High-throughput

0.479

High

1409797

XPO7
Exportin-7

1

1

High-throughput

0.479

High

1409798

NGAP
Ras GTPase-activating protein nGAP

1

1

High-throughput

0.479

High

1409805

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.479

High

1409808

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

1

Small-scale

0.479

High

252150

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

262123

NBN
Nibrin

1

0

Small-scale

0.458

High

269603

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

339101

NADK
NAD kinase

1

0

High-throughput

0.458

High

377703

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

583600

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

Small-scale

0.458

High

710450

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.458

High

831316

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

845775

MUC18
Cell surface glycoprotein MUC18

1

0

Small-scale

0.458

High

873920

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.458

High

941048

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

1065756

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.458

High

1092482

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

0

High-throughput

0.458

High

1095772

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

1129975

MELK
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.458

High

1134042

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1146981

PCBP2
Poly(rC)-binding protein 2

1

0

Small-scale

0.458

High

1178334

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1216021

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.458

High

1234925

PKHA7
Pleckstrin homology domain-containing family A member 7

1

0

High-throughput

0.458

High

1286535

PHLB2
Pleckstrin homology-like domain family B member 2

1

0

High-throughput

0.458

High

1338104

NAV1
Neuron navigator 1

1

0

High-throughput

0.458

High

1360394

SRS12
Serine/arginine-rich splicing factor 12

1

0

High-throughput

0.458

High

1364978

TSC1
Hamartin

1

0

Small-scale

0.458

High

1400861

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1401105

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

0

High-throughput

0.458

High

1402210

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

1409779

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1409780

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1409784

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1409791

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1409792

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

1409793

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.458

High

1409794

CING
Cingulin

1

0

High-throughput

0.458

High

1409795

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1409796

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

1409799

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

1409801

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1409802

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

1409809

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

1409811

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.458

High

944051

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

978685

RL23A
Large ribosomal subunit protein uL23

1

1

Small-scale

0.445

High

1258560

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

1257036

SYDE1
Rho GTPase-activating protein SYDE1

1

1

High-throughput

0.437

High

1352631

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

1

High-throughput

0.437

High

1409785

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

372974

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.426

High

457651

TBB5
Tubulin beta chain

1

0

High-throughput

0.426

High

537795

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

848818

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.426

High

860336

RS9
Small ribosomal subunit protein uS4

1

0

Small-scale

0.426

High

906342

GPC3
Glypican-3

1

0

High-throughput

0.426

High

960228

RL26
Large ribosomal subunit protein uL24

1

0

Small-scale

0.426

High

1199671

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1251889

CCNI2
Cyclin-I2

1

0

High-throughput

0.426

High

1397361

CI072
Guanine nucleotide exchange factor C9orf72

1

0

Small-scale

0.426

High

1409789

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.426

High

1409804

TRAK1
Trafficking kinesin-binding protein 1

1

0

High-throughput

0.426

High

1409806

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.426

High

1409807

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.426

High

1178874

CF184
Cilia- and flagella-associated protein 184

2

0

High-throughput

0.313

High

837367

ECI1
Enoyl-CoA delta isomerase 1, mitochondrial

1

0

High-throughput

0.282

High

1187132

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.249

Low

1229900

AN34A
Ankyrin repeat domain-containing protein 34A

1

0

High-throughput

0.249

Low

1211445

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.232

Low

1409800

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025