HitPredict

Interactor 1: SWR1 (O13682)
Helicase swr1 (EC 3.6.4.12)
Gene: SWR1

Interactor 2: ACT (P10989)
Actin (EC 3.6.4.-)
Gene: act1

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	19910462, 19693008
Identification Methods	affinity chromatography technology, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~HSA, Actin~SNF2-rel_dom
Common GO terms	GO:0000812 - Swr1 complex GO:0005524 - ATP binding GO:0045815 - transcription initiation-coupled chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1288 Sp			1 375
+	Sc
		887678 SWR1_YEAST (30-1240): 0: 719: 41.67		ACT_YEAST (1-375): 0: 588: 89.60
+	Hs
		892104 INO80_HUMAN (58-1262): 0: 703: 26.14		ACTB_HUMAN (1-375): 0: 598: 90.40
+	Sc
		859259 INO80_YEAST (59-1171): 0: 608: 24.01		ACT_YEAST (1-375): 0: 588: 89.60
+	Sp
		144858 INO80_SCHPO (19-1155): 0: 602: 23.35		ACT_SCHPO (1-375): 0: 592: 100.00
+	Hs
		891731 CHD3_HUMAN (815-1287): 1.54e-84: 306: 21.74		ACTB_HUMAN (1-375): 0: 598: 90.40
+	Hs
		929837 CHD3_HUMAN (815-1287): 1.54e-84: 306: 21.74		ACTG_HUMAN (1-375): 0: 598: 91.47
+	Hs
		932125 CHD3_HUMAN (815-1287): 1.54e-84: 306: 21.74		ACTC_HUMAN (2-375): 0: 588: 89.04
+	Mm
		929785 SMCA4_MOUSE (772-1285): 8.2e-81: 295: 20.25		ACTG_MOUSE (1-375): 0: 598: 91.47
+	Hs
		891979 EP400_HUMAN (847-1287): 1.78e-79: 291: 30.57		ACTB_HUMAN (1-375): 0: 598: 90.40
+	Hs
		929972 EP400_HUMAN (847-1287): 1.78e-79: 291: 30.57		ACTG_HUMAN (1-375): 0: 598: 91.47
+	Mm
		929795 SMCA2_MOUSE (772-1282): 4.83e-79: 289: 20.88		ACTG_MOUSE (1-375): 0: 598: 91.47
+	Hs
		846910 SMCA4_HUMAN (772-1285): 9.98e-79: 288: 19.11		ACTB_HUMAN (1-375): 0: 598: 90.40
+	Hs
		846917 SMCA4_HUMAN (772-1285): 9.98e-79: 288: 19.11		ACTG_HUMAN (1-375): 0: 598: 91.47
+	Mm
		929800 EP400_MOUSE (845-1287): 3.85e-78: 287: 30.65		ACTG_MOUSE (1-375): 0: 598: 91.47
+	Dm
		501486 BRM_DROME (813-1260): 1.37e-78: 288: 23.09		ACT1_DROME (2-375): 0: 593: 90.91
+	Dm
		361138 BRM_DROME (813-1260): 1.37e-78: 288: 23.09		ACT2_DROME (2-375): 0: 592: 90.91
+	Hs
		932332 EP400_HUMAN (847-1287): 1.78e-79: 291: 30.57		ACTC_HUMAN (2-375): 0: 588: 89.04
+	Hs
		846742 SMCA2_HUMAN (772-1282): 7.73e-79: 288: 20.88		ACTC_HUMAN (2-375): 0: 588: 89.04
+	Hs
		846918 SMCA4_HUMAN (772-1285): 9.98e-79: 288: 19.11		ACTC_HUMAN (2-375): 0: 588: 89.04
+	Hs
		846919 SMCA4_HUMAN (772-1285): 9.98e-79: 288: 19.11		ACTS_HUMAN (2-375): 0: 588: 89.04