Protein: IMA4
Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)

Gene: IMA4, KPNA3
Organism: Homo sapiens
Interactions: 210
UniProt ID: O00505

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005643 - nuclear pore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006606 - protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

138783

NUP50
Nuclear pore complex protein Nup50

5

20

High-throughput

0.932

High

138688

IMB1
Importin subunit beta-1

4

20

Small-scale

0.906

High

138588

IMA3
Importin subunit alpha-3

2

8

High-throughput

0.789

High

138735

ESR2
Estrogen receptor beta

2

9

High-throughput

0.783

High

138612

ESR1
Estrogen receptor

2

9

High-throughput

0.737

High

138619

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

4

6

High-throughput

0.711

High

138687

KIF22
Kinesin-like protein KIF22

4

3

High-throughput

0.704

High

138656

MECP2
Methyl-CpG-binding protein 2

4

9

High-throughput

0.699

High

138626

RCC1
Regulator of chromosome condensation

4

2

Small-scale

0.696

High

138665

RAN
GTP-binding nuclear protein Ran

1

6

High-throughput

0.691

High

138773

DDX21
Nucleolar RNA helicase 2

3

4

High-throughput

0.683

High

138657

NCBP2
Nuclear cap-binding protein subunit 2

4

5

High-throughput

0.678

High

138777

MAT2B
Methionine adenosyltransferase 2 subunit beta

3

2

High-throughput

0.675

High

138759

IER2
Immediate early response gene 2 protein

3

1

High-throughput

0.667

High

138628

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

High-throughput

0.665

High

138673

NCBP1
Nuclear cap-binding protein subunit 1

3

5

High-throughput

0.662

High

138627

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

3

2

High-throughput

0.654

High

138691

BRD3
Bromodomain-containing protein 3

3

12

High-throughput

0.653

High

138670

TF65
Transcription factor p65

3

9

High-throughput

0.640

High

138682

SQSTM
Sequestosome-1

3

3

High-throughput

0.640

High

138789

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

2

1

High-throughput

0.640

High

138702

LARP7
La-related protein 7

3

7

Small-scale

0.633

High

138681

MTA1
Metastasis-associated protein MTA1

2

12

High-throughput

0.631

High

138663

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

4

High-throughput

0.628

High

138668

HSF1
Heat shock factor protein 1

2

4

High-throughput

0.628

High

138745

P121A
Nuclear envelope pore membrane protein POM 121

2

15

High-throughput

0.628

High

138713

ANR11
Ankyrin repeat domain-containing protein 11

1

9

High-throughput

0.621

High

138618

NPM
Nucleophosmin

2

4

Small-scale

0.619

High

138672

RBBP4
Histone-binding protein RBBP4

2

12

Small-scale

0.619

High

138591

XPO1
Exportin-1

1

15

Small-scale

0.618

High

138650

NOTC1
Neurogenic locus notch homolog protein 1

1

1

Small-scale

0.618

High

138755

CIC
Protein capicua homolog

1

7

High-throughput

0.618

High

138756

BARD1
BRCA1-associated RING domain protein 1

1

9

High-throughput

0.618

High

138641

COIL
Coilin

2

2

High-throughput

0.614

High

138620

PARP1
Poly [ADP-ribose] polymerase 1

2

4

High-throughput

0.611

High

138671

CTSL2
CTD small phosphatase-like protein 2

2

4

Small-scale

0.611

High

138684

CUL3
Cullin-3

2

13

High-throughput

0.611

High

138719

F90A1
Protein FAM90A1

3

2

High-throughput

0.607

High

138639

ZNF76
Zinc finger protein 76

2

9

High-throughput

0.606

High

138645

RAD52
DNA repair protein RAD52 homolog

2

1

High-throughput

0.606

High

138648

MK09
Mitogen-activated protein kinase 9

2

3

High-throughput

0.606

High

138680

GRB10
Growth factor receptor-bound protein 10

2

2

High-throughput

0.606

High

138712

ZCH12
Zinc finger CCHC domain-containing protein 12

2

1

High-throughput

0.606

High

138716

ATOSB
Atos homolog protein B

2

1

High-throughput

0.606

High

138724

LMBL4
Lethal(3)malignant brain tumor-like protein 4

2

1

High-throughput

0.606

High

138738

KAT5
Histone acetyltransferase KAT5

2

7

High-throughput

0.606

High

138744

ZN764
Zinc finger protein 764

2

9

High-throughput

0.606

High

138748

TNIP3
TNFAIP3-interacting protein 3

2

1

High-throughput

0.606

High

138751

HEXI2
Protein HEXIM2

2

1

High-throughput

0.606

High

138760

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

5

High-throughput

0.606

High

138771

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

7

High-throughput

0.606

High

138647

CBX5
Chromobox protein homolog 5

2

16

Small-scale

0.601

High

138667

CBX1
Chromobox protein homolog 1

2

16

Small-scale

0.601

High

138790

X5D778
Ankyrin repeat domain 11 isoform A

1

9

High-throughput

0.594

High

138610

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

12

High-throughput

0.586

High

138601

BRD4
Bromodomain-containing protein 4

2

15

High-throughput

0.584

High

138640

BRCA1
Breast cancer type 1 susceptibility protein

2

7

High-throughput

0.584

High

138715

MEPCE
7SK snRNA methylphosphate capping enzyme

2

6

High-throughput

0.584

High

138701

UVSSA
UV-stimulated scaffold protein A

2

0

High-throughput

0.580

High

138729

BAHD1
Bromo adjacent homology domain-containing 1 protein

2

0

High-throughput

0.580

High

138596

ZBT24
Zinc finger and BTB domain-containing protein 24

1

8

High-throughput

0.573

High

138611

FRIL
Ferritin light chain

1

5

High-throughput

0.573

High

138752

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.573

High

138721

SLX4
Structure-specific endonuclease subunit SLX4

2

7

High-throughput

0.571

High

138644

HD
Huntingtin

2

0

High-throughput

0.571

High

138709

C102B
Coiled-coil domain-containing protein 102B

2

1

High-throughput

0.553

High

138703

NCBP3
Nuclear cap-binding protein subunit 3

2

2

High-throughput

0.552

High

138749

SMIP9
Protein SPMIP9

1

0

High-throughput

0.549

High

138616

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

138623

MYOD1
Myoblast determination protein 1

1

3

High-throughput

0.541

High

138651

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

138697

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

High-throughput

0.541

High

138737

GATA6
Transcription factor GATA-6

1

3

High-throughput

0.541

High

138788

FA50B
Protein FAM50B

1

1

High-throughput

0.541

High

138587

NOP56
Nucleolar protein 56

1

14

High-throughput

0.536

High

138589

CUX2
Homeobox protein cut-like 2

1

2

High-throughput

0.536

High

138594

PPM1D
Protein phosphatase 1D

1

2

High-throughput

0.536

High

138597

MED14
Mediator of RNA polymerase II transcription subunit 14

1

3

High-throughput

0.536

High

138600

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

6

High-throughput

0.536

High

138602

NPM3
Nucleoplasmin-3

1

4

High-throughput

0.536

High

138603

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.536

High

138617

RB
Retinoblastoma-associated protein

1

1

High-throughput

0.536

High

138634

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

5

High-throughput

0.536

High

138646

RANG
Ran-specific GTPase-activating protein

1

20

High-throughput

0.536

High

138653

NU153
Nuclear pore complex protein Nup153

1

20

High-throughput

0.536

High

138654

RBP2
E3 SUMO-protein ligase RanBP2

1

10

High-throughput

0.536

High

138655

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

High-throughput

0.536

High

138660

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

138661

RRP1
Ribosomal RNA processing protein 1 homolog A

1

1

High-throughput

0.536

High

138666

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.536

High

138669

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

High-throughput

0.536

High

138676

ILF3
Interleukin enhancer-binding factor 3

1

5

High-throughput

0.536

High

138683

HDAC1
Histone deacetylase 1

1

12

High-throughput

0.536

High

138689

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

High-throughput

0.536

High

138695

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

138736

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.536

High

138747

Z512B
Zinc finger protein 512B

1

8

High-throughput

0.536

High

138768

PHAX
Phosphorylated adapter RNA export protein

1

3

High-throughput

0.536

High

138770

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

3

High-throughput

0.536

High

138775

MRGBP
MRG/MORF4L-binding protein

1

2

High-throughput

0.536

High

138776

MED9
Mediator of RNA polymerase II transcription subunit 9

1

1

High-throughput

0.536

High

138779

SAE1
SUMO-activating enzyme subunit 1

1

4

High-throughput

0.536

High

138635

ARRB2
Beta-arrestin-2

1

2

High-throughput

0.515

High

138652

ARRB1
Beta-arrestin-1

1

2

High-throughput

0.515

High

138705

ZN326
DBIRD complex subunit ZNF326

1

3

High-throughput

0.515

High

138743

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

Small-scale

0.515

High

138758

Q9BRL8
MTA1 protein

1

10

High-throughput

0.515

High

138625

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

138593

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

138630

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

14

Small-scale

0.501

High

138658

ZN131
Zinc finger protein 131

1

8

Small-scale

0.501

High

138699

HIF1A
Hypoxia-inducible factor 1-alpha

1

13

Small-scale

0.501

High

138757

EPAS1
Endothelial PAS domain-containing protein 1

1

13

Small-scale

0.501

High

138649

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.500

High

138633

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.494

High

138679

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.481

High

138686

MVP
Major vault protein

1

2

High-throughput

0.481

High

138782

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

4

Small-scale

0.481

High

128604

MEN1
Menin

1

2

High-throughput

0.479

High

131566

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

138590

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

138592

MDM4
Protein Mdm4

1

2

Small-scale

0.479

High

138595

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

138598

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

138599

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

138604

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

138605

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

7

Small-scale

0.479

High

138607

PCNT
Pericentrin

1

2

High-throughput

0.479

High

138608

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

138613

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

138614

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

138624

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

138629

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.479

High

138631

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

138637

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

138638

NU214
Nuclear pore complex protein Nup214

1

9

Small-scale

0.479

High

138642

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

138643

WASP
Actin nucleation-promoting factor WAS

1

5

Small-scale

0.479

High

138659

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

138662

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

138664

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

138674

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

138675

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

138677

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

138678

GRM1
Metabotropic glutamate receptor 1

1

1

Small-scale

0.479

High

138685

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

138690

HAPR1
HUWE1-associated protein modifying stress responses 1

1

4

High-throughput

0.479

High

138692

KS6A2
Ribosomal protein S6 kinase alpha-2

1

5

High-throughput

0.479

High

138693

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

138696

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

138698

RBBP7
Histone-binding protein RBBP7

1

12

High-throughput

0.479

High

138700

CL16A
Protein CLEC16A

1

3

High-throughput

0.479

High

138704

AKIR2
Akirin-2

1

3

Small-scale

0.479

High

138708

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

138711

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

138717

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

138720

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

138722

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

7

Small-scale

0.479

High

138725

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

138728

COP1
E3 ubiquitin-protein ligase COP1

1

18

High-throughput

0.479

High

138733

DDB2
DNA damage-binding protein 2

1

9

High-throughput

0.479

High

138734

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

138739

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

138740

MRTFA
Myocardin-related transcription factor A

1

2

Small-scale

0.479

High

138742

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

138750

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

138754

NACC1
Nucleus accumbens-associated protein 1

1

16

Small-scale

0.479

High

138763

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

138764

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.479

High

138765

AICDA
Single-stranded DNA cytosine deaminase

1

5

Small-scale

0.479

High

138767

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

138772

SENP2
Sentrin-specific protease 2

1

4

Small-scale

0.479

High

138778

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

138780

NXF1
Nuclear RNA export factor 1

1

4

High-throughput

0.479

High

138781

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

138784

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

12

High-throughput

0.479

High

138786

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

75599

B3KTP4
Apolipoprotein L, 6

1

1

High-throughput

0.470

High

138636

TF2H1
General transcription factor IIH subunit 1

1

0

High-throughput

0.460

High

138606

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

138632

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

138707

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

138727

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

138731

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

138741

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

138762

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

138694

SF01
Splicing factor 1

1

7

High-throughput

0.457

High

68005

P121C
Nuclear envelope pore membrane protein POM 121C

1

18

High-throughput

0.445

High

138622

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

138706

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

138710

PKHA7
Pleckstrin homology domain-containing family A member 7

1

12

High-throughput

0.445

High

138726

ZBT34
Zinc finger and BTB domain-containing protein 34

1

17

Small-scale

0.445

High

138746

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.445

High

138753

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.445

High

138785

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.445

High

138761

APOL6
Apolipoprotein L6

1

1

High-throughput

0.439

High

138774

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

76075

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

17

High-throughput

0.437

High

138609

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

138615

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

138714

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

138718

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.437

High

138723

FBXL6
F-box/LRR-repeat protein 6

1

5

High-throughput

0.437

High

138766

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

138769

F204A
Protein FAM204A

1

1

High-throughput

0.437

High

138791

X5D7R7
Major vault protein

1

2

High-throughput

0.417

High

138732

SC5AB
Sodium/myo-inositol cotransporter 2

2

0

High-throughput

0.341

High

138730

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.299

High

138621

TM276
Transmembrane protein 276

1

0

High-throughput

0.268

Low

138787

UTP16
U3 small nucleolar RNA-associated protein NOL7

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025