Protein: IMA7
Importin subunit alpha-7 (Karyopherin subunit alpha-6)

Gene: IMA7, KPNA6
Organism: Homo sapiens
Interactions: 153
UniProt ID: O60684

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006366 - transcription by RNA polymerase II
GO:0006606 - protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

253703

NUP50
Nuclear pore complex protein Nup50

8

20

High-throughput

0.972

High

253602

IMA5
Importin subunit alpha-5

4

8

High-throughput

0.895

High

253632

IMB1
Importin subunit beta-1

3

20

Small-scale

0.871

High

207719

MCES
mRNA cap guanine-N(7) methyltransferase

6

5

High-throughput

0.734

High

253574

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

6

12

High-throughput

0.730

High

253610

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.724

High

253606

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.698

High

253639

TAF9
Transcription initiation factor TFIID subunit 9

3

4

High-throughput

0.667

High

253582

LMNB1
Lamin-B1

3

12

High-throughput

0.665

High

253667

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

3

10

High-throughput

0.665

High

253581

PTN2
Tyrosine-protein phosphatase non-receptor type 2

3

2

High-throughput

0.656

High

253601

NU153
Nuclear pore complex protein Nup153

2

20

High-throughput

0.628

High

253623

HDAC1
Histone deacetylase 1

2

12

High-throughput

0.628

High

253685

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

2

11

High-throughput

0.628

High

253698

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

20

High-throughput

0.628

High

253589

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

2

11

High-throughput

0.625

High

253621

SKP2
S-phase kinase-associated protein 2

2

5

Small-scale

0.624

High

253645

ANR11
Ankyrin repeat domain-containing protein 11

1

9

High-throughput

0.621

High

179011

IMA6
Importin subunit alpha-6

1

8

High-throughput

0.618

High

253583

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

9

Small-scale

0.618

High

253596

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.618

High

253647

BCOR
BCL-6 corepressor

1

9

Small-scale

0.618

High

253653

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

11

Small-scale

0.618

High

253658

ARMC8
Armadillo repeat-containing protein 8

1

10

High-throughput

0.618

High

253702

XPO7
Exportin-7

1

5

High-throughput

0.618

High

253620

G3BP1
Ras GTPase-activating protein-binding protein 1

2

5

High-throughput

0.611

High

253625

CUL3
Cullin-3

2

13

High-throughput

0.611

High

253691

XRN2
5'-3' exoribonuclease 2

2

1

High-throughput

0.611

High

253700

LYAR
Cell growth-regulating nucleolar protein

2

4

High-throughput

0.611

High

253699

KBTB4
Kelch repeat and BTB domain-containing protein 4

3

6

Small-scale

0.609

High

253608

PO6F2
POU domain, class 6, transcription factor 2

2

10

High-throughput

0.606

High

253671

KAT5
Histone acetyltransferase KAT5

2

7

High-throughput

0.606

High

253673

DCPS
m7GpppX diphosphatase

2

2

High-throughput

0.606

High

253676

P121A
Nuclear envelope pore membrane protein POM 121

2

15

High-throughput

0.606

High

253686

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

5

High-throughput

0.606

High

253696

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

7

High-throughput

0.606

High

253706

MAGD1
Melanoma-associated antigen D1

2

1

High-throughput

0.606

High

253640

HIF1A
Hypoxia-inducible factor 1-alpha

2

13

Small-scale

0.602

High

227267

SPOP
Speckle-type POZ protein

2

9

High-throughput

0.601

High

253603

NCBP2
Nuclear cap-binding protein subunit 2

2

5

High-throughput

0.601

High

253611

RELB
Transcription factor RelB

2

9

High-throughput

0.601

High

253615

NCBP1
Nuclear cap-binding protein subunit 1

2

5

High-throughput

0.601

High

253708

X5D778
Ankyrin repeat domain 11 isoform A

1

9

High-throughput

0.594

High

253636

SURF2
Surfeit locus protein 2

2

0

High-throughput

0.585

High

240236

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

253590

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

253631

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

20

Small-scale

0.584

High

253633

HAPR1
HUWE1-associated protein modifying stress responses 1

2

4

High-throughput

0.584

High

253650

MEPCE
7SK snRNA methylphosphate capping enzyme

2

6

High-throughput

0.584

High

167042

GEMI2
Gem-associated protein 2

2

0

High-throughput

0.580

High

253661

SR1IP
Protein SREK1IP1

2

3

High-throughput

0.574

High

253594

NOP2
28S rRNA

1

1

High-throughput

0.573

High

253642

LARP7
La-related protein 7

2

7

Small-scale

0.571

High

253595

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.561

High

253628

KEAP1
Kelch-like ECH-associated protein 1

1

3

Small-scale

0.561

High

253657

F90A1
Protein FAM90A1

2

2

High-throughput

0.553

High

253573

IL1A
Interleukin-1 alpha

1

0

High-throughput

0.549

High

253616

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

High-throughput

0.541

High

253626

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.541

High

140678

NOP56
Nucleolar protein 56

1

13

High-throughput

0.536

High

155263

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

3

High-throughput

0.536

High

186177

PPM1D
Protein phosphatase 1D

1

2

High-throughput

0.536

High

253580

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.536

High

253600

CLK3
Dual specificity protein kinase CLK3

1

9

High-throughput

0.536

High

253609

CBX1
Chromobox protein homolog 1

1

16

High-throughput

0.536

High

253614

RBBP4
Histone-binding protein RBBP4

1

12

High-throughput

0.536

High

253617

ILF3
Interleukin enhancer-binding factor 3

1

5

High-throughput

0.536

High

253618

CBX3
Chromobox protein homolog 3

1

16

High-throughput

0.536

High

253630

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

11

High-throughput

0.536

High

253635

NONO
Non-POU domain-containing octamer-binding protein

1

1

High-throughput

0.536

High

253638

RBBP7
Histone-binding protein RBBP7

1

12

High-throughput

0.536

High

253644

ALKB5
RNA demethylase ALKBH5

1

1

High-throughput

0.536

High

253652

TAD2B
Transcriptional adapter 2-beta

1

5

High-throughput

0.536

High

253659

KLHL7
Kelch-like protein 7

1

3

High-throughput

0.536

High

253665

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

253668

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.536

High

253677

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.536

High

253684

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

1

High-throughput

0.536

High

253690

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.536

High

253692

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.536

High

253695

EAF6
Chromatin modification-related protein MEAF6

1

2

High-throughput

0.536

High

253697

SP110
Sp110 nuclear body protein

1

17

High-throughput

0.536

High

253705

NOP58
Nucleolar protein 58

1

13

High-throughput

0.536

High

253629

IRF3
Interferon regulatory factor 3

1

5

Small-scale

0.534

High

253569

JERKY
Jerky protein homolog

1

3

High-throughput

0.515

High

253649

CENPU
Centromere protein U

1

0

High-throughput

0.513

High

253664

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

185281

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

253585

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

14

Small-scale

0.501

High

253604

ZN131
Zinc finger protein 131

1

8

Small-scale

0.501

High

253669

CBP
CREB-binding protein

1

13

Small-scale

0.501

High

253683

EPAS1
Endothelial PAS domain-containing protein 1

1

13

Small-scale

0.501

High

253656

CACL1
CDK2-associated and cullin domain-containing protein 1

1

14

High-throughput

0.489

High

128655

MEN1
Menin

1

2

High-throughput

0.479

High

133069

FOXE1
Forkhead box protein E1

1

5

High-throughput

0.479

High

186960

PPM1G
Protein phosphatase 1G

1

5

High-throughput

0.479

High

247547

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

253570

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

3

Small-scale

0.479

High

253571

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

253572

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

1

High-throughput

0.479

High

253575

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

253577

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

253578

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

253584

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.479

High

253586

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

253587

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

253588

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.479

High

253593

GATA4
Transcription factor GATA-4

1

3

High-throughput

0.479

High

253597

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

253598

CENPA
Histone H3-like centromeric protein A

1

7

High-throughput

0.479

High

253599

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

253605

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.479

High

253607

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.479

High

253612

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

253613

CTSL2
CTD small phosphatase-like protein 2

1

4

Small-scale

0.479

High

253619

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

253622

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

253624

IRF5
Interferon regulatory factor 5

1

5

Small-scale

0.479

High

253634

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

253641

CL16A
Protein CLEC16A

1

3

High-throughput

0.479

High

253651

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

253655

NLRC5
Protein NLRC5

1

2

Small-scale

0.479

High

253660

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

253663

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

253666

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

253670

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.479

High

253674

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

253675

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

High-throughput

0.479

High

253678

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

253682

PHB2
Prohibitin-2

1

5

Small-scale

0.479

High

253688

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

253689

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.479

High

253701

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

253704

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

High-throughput

0.479

High

253707

NEMO
NF-kappa-B essential modulator

1

3

Small-scale

0.479

High

253592

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.458

High

253654

MET16
RNA N(6)-adenosine-methyltransferase METTL16

1

0

High-throughput

0.458

High

253672

ARK2N
Protein ARK2N

1

0

High-throughput

0.458

High

253679

CAR19
Caspase recruitment domain-containing protein 19

1

0

Small-scale

0.458

High

253637

SF01
Splicing factor 1

1

7

High-throughput

0.457

High

253579

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

253591

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

Small-scale

0.445

High

253627

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

253643

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

253662

ZBT34
Zinc finger and BTB domain-containing protein 34

1

17

Small-scale

0.445

High

253680

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.445

High

253687

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

1

High-throughput

0.445

High

253694

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

253576

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

253646

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

253648

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

253693

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

253681

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High


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Last updated: 11Aug2025