HitPredict

Interactor 1: SMC5 (O13710)
Structural maintenance of chromosomes protein 5 (DNA repair protein spr18) (SMC partner of rad18)
Gene: SMC5

Interactor 2: NSE4 (Q6BDR8)
Non-structural maintenance of chromosome element 4 (Non-SMC element 4) (DNA repair protein rad62)
Gene: NSE4

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	16478984, 15331764, 17005570
Identification Methods	affinity chromatography technology, pull down, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000724 - double-strand break repair via homologous recombination GO:0005634 - nucleus GO:0030915 - Smc5-Smc6 complex GO:0051321 - meiotic cell cycle
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1076 Sp			1 300
+	Hs
		1221561 SMC5_HUMAN (6-1076): 2.87e-94: 326: 22.84		EID3_HUMAN (2-287): 3.61e-112: 329: 25.74
+	Hs
		1221781 SMC5_HUMAN (6-1076): 2.87e-94: 326: 22.84		NSE4A_HUMAN (7-283): 9.95e-100: 299: 25.59
+	Mm
		1113676 SMC6_MOUSE (13-1044): 1.02e-70: 258: 15.80		EID3_MOUSE (4-283): 5.94e-116: 340: 26.94
+	Sp
		864195 SMC6_SCHPO (18-1032): 1.58e-62: 234: 15.29		NSE4_SCHPO (1-300): 1.05e-120: 349: 100.00
+	Hs
		1230244 SMC6_HUMAN (13-1044): 8.44e-69: 253: 15.89		EID3_HUMAN (2-287): 3.61e-112: 329: 25.74
+	Mm
		103329 SMC6_MOUSE (13-1044): 1.02e-70: 258: 15.80		G3XA30_MOUSE (7-284): 2.27e-104: 311: 26.35
+	Hs
		1302136 SMC6_HUMAN (13-1044): 8.44e-69: 253: 15.89		NSE4A_HUMAN (7-283): 9.95e-100: 299: 25.59
+	Sc
		793577 SMC5_YEAST (4-1057): 3.09e-82: 292: 22.84		NSE4_YEAST (62-283): 3.1e-63: 206: 23.55
+	Sc
		793581 SMC6_YEAST (16-1032): 1.76e-54: 209: 14.04		NSE4_YEAST (62-283): 3.1e-63: 206: 23.55