HitPredict

Interactor 1: CUL1 (O13790)
Cullin-1 (Cul-1) (Cell division control 53 homolog)
Gene: CUL1

Interactor 2: SKP1 (Q9Y709)
Suppressor of kinetochore protein 1 (P19/Skp1 homolog)
Gene: SKP1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	15147268, 15555586, 11337588, 12167173, 23535663
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~Skp1_POZ
Common GO terms	GO:0005829 - cytosol GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0043224 - nuclear SCF ubiquitin ligase complex GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 767 Sp			1 161
+	Mm
		1376703 CUL1_MOUSE (4-767): 0: 803: 40.79		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Hs
		928899 CUL1_HUMAN (4-767): 0: 800: 40.66		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Hs
		928901 CUL3_HUMAN (9-767): 0: 773: 28.55		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Hs
		928902 CUL4A_HUMAN (7-767): 0: 770: 28.79		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Dm
		284976 CUL1_DROME (13-767): 0: 763: 39.43		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Hs
		928903 CUL4B_HUMAN (7-767): 0: 753: 28.79		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Dm
		1097192 CUL1_DROME (13-767): 0: 763: 39.43		Q7KJ69_DROME (1-161): 4.35e-74: 220: 53.37
+	Hs
		928900 CUL2_HUMAN (14-767): 0: 732: 30.40		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	At
		1277333 CUL1_ARATH (13-767): 0: 730: 27.74		ASK4_ARATH (4-158): 3.73e-80: 235: 44.52
+	Dm
		284981 Q5BI50_DROME (7-767): 0: 733: 28.17		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	At
		1277346 CUL1_ARATH (13-767): 0: 730: 27.74		ASK3_ARATH (4-158): 1.93e-78: 231: 43.23
+	At
		1107618 CUL1_ARATH (13-767): 0: 730: 27.74		SKP1A_ARATH (3-158): 1.64e-75: 224: 51.28
+	At
		1277329 CUL1_ARATH (13-767): 0: 730: 27.74		SKP1B_ARATH (3-158): 1e-73: 220: 48.49
+	At
		221655 CUL1_ARATH (13-767): 0: 730: 27.74		ASK11_ARATH (4-158): 3.3e-74: 220: 50.32
+	At
		1277337 CUL1_ARATH (13-767): 0: 730: 27.74		ASK10_ARATH (3-157): 1.17e-71: 213: 41.94
+	At
		1277341 CUL1_ARATH (13-767): 0: 730: 27.74		ASK13_ARATH (1-158): 5.51e-68: 205: 44.72
+	At
		286197 CUL1_ARATH (13-767): 0: 730: 27.74		ASK14_ARATH (2-158): 5.69e-67: 201: 42.41
+	At
		1093271 CUL1_ARATH (13-767): 0: 730: 27.74		ASK15_ARATH (2-158): 2.87e-65: 198: 44.79
+	At
		286162 CUL1_ARATH (13-767): 0: 730: 27.74		ASK16_ARATH (2-158): 2.89e-64: 196: 38.65
+	At
		286251 CUL1_ARATH (13-767): 0: 730: 27.74		ASK19_ARATH (3-157): 1.78e-62: 192: 36.96