Protein: KLF12
Krueppel-like factor 12 (Transcriptional repressor AP-2rep)

Gene: KLF12
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q9Y4X4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1103475

CTBP1
C-terminal-binding protein 1

4

12

High-throughput

0.709

High

1396334

EHMT2
Histone-lysine N-methyltransferase EHMT2

4

19

High-throughput

0.694

High

1123183

FHL2
Four and a half LIM domains protein 2

3

16

High-throughput

0.665

High

177486

ZN536
Zinc finger protein 536

1

20

High-throughput

0.618

High

229378

ZBT14
Zinc finger and BTB domain-containing protein 14

1

19

High-throughput

0.618

High

245652

ZEB2
Zinc finger E-box-binding homeobox 2

1

20

High-throughput

0.618

High

277201

ZN217
Zinc finger protein 217

1

20

High-throughput

0.618

High

586359

ZEP1
Zinc finger protein 40

1

20

High-throughput

0.618

High

675738

TYY1
Transcriptional repressor protein YY1

1

19

High-throughput

0.618

High

790115

ZEB1
Zinc finger E-box-binding homeobox 1

1

20

High-throughput

0.618

High

886628

CTCF
Transcriptional repressor CTCF

1

19

High-throughput

0.618

High

1040956

MECOM
Histone-lysine N-methyltransferase MECOM

1

20

High-throughput

0.618

High

1085860

TF3C1
General transcription factor 3C polypeptide 1

1

2

High-throughput

0.618

High

1092867

PRDM2
PR domain zinc finger protein 2

1

19

High-throughput

0.618

High

1365827

ZN516
Zinc finger protein 516

1

20

High-throughput

0.618

High

1368019

RREB1
Ras-responsive element-binding protein 1

1

20

High-throughput

0.618

High

1380374

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

19

High-throughput

0.618

High

1396159

Z512B
Zinc finger protein 512B

1

19

High-throughput

0.618

High

1398108

ZN512
Zinc finger protein 512

1

20

High-throughput

0.618

High

1434517

ZN644
Zinc finger protein 644

1

19

High-throughput

0.618

High

1437892

PRD16
Histone-lysine N-methyltransferase PRDM16

1

20

High-throughput

0.618

High

1462776

ZN148
Zinc finger protein 148

1

20

High-throughput

0.618

High

1490996

ZN281
Zinc finger protein 281

1

20

High-throughput

0.618

High

1116628

FHL3
Four and a half LIM domains protein 3

2

16

High-throughput

0.606

High

423527

A4
Amyloid-beta precursor protein

2

19

High-throughput

0.602

High

1253609

I23O2
Indoleamine 2,3-dioxygenase 2

2

0

High-throughput

0.602

High

1450898

THAP1
THAP domain-containing protein 1

1

6

High-throughput

0.573

High

346559

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

18

High-throughput

0.536

High

902645

RT29
Small ribosomal subunit protein mS29

1

4

High-throughput

0.536

High

1011759

RT35
Small ribosomal subunit protein mS35

1

5

High-throughput

0.536

High

1012389

RT15
Small ribosomal subunit protein uS15m

1

3

High-throughput

0.536

High

1271628

DHX30
ATP-dependent RNA helicase DHX30

1

8

High-throughput

0.536

High

1390084

PTCD3
Small ribosomal subunit protein mS39

1

3

High-throughput

0.536

High

1491196

RT16
Small ribosomal subunit protein bS16m

1

2

High-throughput

0.536

High

1418951

RT26
Small ribosomal subunit protein mS26

1

4

High-throughput

0.515

High

656277

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.515

High

844133

HD
Huntingtin

1

10

High-throughput

0.515

High

967071

1433G
14-3-3 protein gamma

1

5

High-throughput

0.515

High

1139883

SETB1
Histone-lysine N-methyltransferase SETDB1

1

20

High-throughput

0.515

High

1347419

LMO3
LIM domain only protein 3

1

16

High-throughput

0.515

High

1371344

KAT5
Histone acetyltransferase KAT5

1

6

High-throughput

0.515

High

1371804

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

17

High-throughput

0.501

High

141188

NOP56
Nucleolar protein 56

1

4

High-throughput

0.500

High

301273

RL1D1
Ribosomal L1 domain-containing protein 1

1

9

High-throughput

0.500

High

431288

LA
Lupus La protein

1

12

High-throughput

0.500

High

552736

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.500

High

995511

TPM4
Tropomyosin alpha-4 chain

1

10

High-throughput

0.500

High

1130553

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

12

High-throughput

0.500

High

1210563

HP1B3
Heterochromatin protein 1-binding protein 3

1

3

High-throughput

0.500

High

1328330

RM50
Large ribosomal subunit protein mL50

1

1

High-throughput

0.500

High

1351094

DDX54
ATP-dependent RNA helicase DDX54

1

12

High-throughput

0.500

High

1414369

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

11

High-throughput

0.500

High

1491463

RT18B
Small ribosomal subunit protein mS40

1

6

High-throughput

0.500

High

256420

RT14
Small ribosomal subunit protein uS14m

1

4

High-throughput

0.489

High

1011230

RT22
Small ribosomal subunit protein mS22

1

4

High-throughput

0.489

High

1011417

RT25
Small ribosomal subunit protein mS25

1

2

High-throughput

0.489

High

1011939

RT05
Small ribosomal subunit protein uS5m

1

8

High-throughput

0.489

High

1012293

RT11
Small ribosomal subunit protein uS11m

1

4

High-throughput

0.489

High

1012668

RT34
Small ribosomal subunit protein mS34

1

5

High-throughput

0.489

High

1013035

RT09
Small ribosomal subunit protein uS9m

1

12

High-throughput

0.489

High

1364440

RT27
Small ribosomal subunit protein mS27

1

3

High-throughput

0.489

High

1366483

RT31
Small ribosomal subunit protein mS31

1

4

High-throughput

0.489

High

1389251

RT24
Small ribosomal subunit protein uS3m

1

3

High-throughput

0.489

High

1428602

DDX24
ATP-dependent RNA helicase DDX24

1

16

High-throughput

0.489

High

1432605

CPVL
Probable serine carboxypeptidase CPVL

1

4

High-throughput

0.489

High

1490897

RT07
Small ribosomal subunit protein uS7m

1

11

High-throughput

0.489

High

1491102

RT02
Small ribosomal subunit protein uS2m

1

6

High-throughput

0.489

High

1491148

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.489

High

1491215

RT23
Small ribosomal subunit protein mS23

1

4

High-throughput

0.489

High

1460708

DNM3L
DNA

1

0

Small-scale

0.480

High

1213383

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.479

High

135399

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

12

High-throughput

0.479

High

143352

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

175955

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

High-throughput

0.479

High

282807

E2F6
Transcription factor E2F6

1

10

High-throughput

0.479

High

283581

TAD2A
Transcriptional adapter 2-alpha

1

16

High-throughput

0.479

High

284905

TADA3
Transcriptional adapter 3

1

5

High-throughput

0.479

High

345029

WIZ
Protein Wiz

1

20

High-throughput

0.479

High

414917

P53
Cellular tumor antigen p53

1

11

Small-scale

0.479

High

474403

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

559783

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

612029

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.479

High

624274

TFE3
Transcription factor E3

1

15

High-throughput

0.479

High

651113

RFX1
MHC class II regulatory factor RFX1

1

15

High-throughput

0.479

High

711847

KDM5A
Lysine-specific demethylase 5A

1

7

High-throughput

0.479

High

824445

RL13A
Large ribosomal subunit protein uL13

1

5

High-throughput

0.479

High

860070

RL28
Large ribosomal subunit protein eL28

1

6

High-throughput

0.479

High

879666

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

High-throughput

0.479

High

892073

TAF6
Transcription initiation factor TFIID subunit 6

1

4

High-throughput

0.479

High

895178

EMD
Emerin

1

10

High-throughput

0.479

High

913824

ZN131
Zinc finger protein 131

1

20

High-throughput

0.479

High

926441

BLM
RecQ-like DNA helicase BLM

1

9

High-throughput

0.479

High

927631

ATX1
Ataxin-1

1

8

High-throughput

0.479

High

941620

CTBP2
C-terminal-binding protein 2

1

12

High-throughput

0.479

High

960314

RL26
Large ribosomal subunit protein uL24

1

12

High-throughput

0.479

High

965370

WDR5
WD repeat-containing protein 5

1

13

High-throughput

0.479

High

982898

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.479

High

984670

RL39
Large ribosomal subunit protein eL39

1

4

High-throughput

0.479

High

1017518

FOXK1
Forkhead box protein K1

1

17

High-throughput

0.479

High

1024248

TFAM
Transcription factor A, mitochondrial

1

18

High-throughput

0.479

High

1041629

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.479

High

1045949

TF65
Transcription factor p65

1

17

High-throughput

0.479

High

1048185

TLE4
Transducin-like enhancer protein 4

1

20

High-throughput

0.479

High

1055644

GABPA
GA-binding protein alpha chain

1

20

High-throughput

0.479

High

1067876

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1088127

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1088641

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

14

High-throughput

0.479

High

1112236

KRR1
KRR1 small subunit processome component homolog

1

3

High-throughput

0.479

High

1122877

TFDP1
Transcription factor Dp-1

1

3

High-throughput

0.479

High

1123621

ZMYM3
Zinc finger MYM-type protein 3

1

19

High-throughput

0.479

High

1130233

SMC1A
Structural maintenance of chromosomes protein 1A

1

6

High-throughput

0.479

High

1130894

RRP5
Protein RRP5 homolog

1

7

High-throughput

0.479

High

1152769

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

1155341

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

5

High-throughput

0.479

High

1195620

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

1208661

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

12

High-throughput

0.479

High

1236086

LIN54
Protein lin-54 homolog

1

4

High-throughput

0.479

High

1250480

MCAF1
Activating transcription factor 7-interacting protein 1

1

19

High-throughput

0.479

High

1250700

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

1278989

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

High-throughput

0.479

High

1288016

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

1295332

P66A
Transcriptional repressor p66-alpha

1

2

High-throughput

0.479

High

1309385

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

1310148

MGAP
MAX gene-associated protein

1

12

High-throughput

0.479

High

1315082

ZZZ3
ZZ-type zinc finger-containing protein 3

1

2

High-throughput

0.479

High

1326173

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.479

High

1340174

KDM2B
Lysine-specific demethylase 2B

1

12

High-throughput

0.479

High

1350660

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

14

High-throughput

0.479

High

1352175

MORC4
MORC family CW-type zinc finger protein 4

1

2

High-throughput

0.479

High

1357176

GATD1
GATA zinc finger domain-containing protein 1

1

5

High-throughput

0.479

High

1369186

KAT2A
Histone acetyltransferase KAT2A

1

20

High-throughput

0.479

High

1369232

KAT2B
Histone acetyltransferase KAT2B

1

20

High-throughput

0.479

High

1380998

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

12

High-throughput

0.479

High

1385320

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

20

High-throughput

0.479

High

1395266

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

16

High-throughput

0.479

High

1396765

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

1401065

PHF12
PHD finger protein 12

1

20

High-throughput

0.479

High

1401471

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1404873

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1407798

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1412840

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

1413370

MTA3
Metastasis-associated protein MTA3

1

18

High-throughput

0.479

High

1418418

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

1419745

GTPB4
GTP-binding protein 4

1

8

High-throughput

0.479

High

1428502

REXO4
RNA exonuclease 4

1

4

High-throughput

0.479

High

1430106

RGAP1
Rac GTPase-activating protein 1

1

17

High-throughput

0.479

High

1431826

EPC1
Enhancer of polycomb homolog 1

1

10

High-throughput

0.479

High

1433685

ZHX3
Zinc fingers and homeoboxes protein 3

1

20

High-throughput

0.479

High

1436249

CSR2B
Cysteine-rich protein 2-binding protein

1

1

High-throughput

0.479

High

1436932

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

16

High-throughput

0.479

High

1437060

ARP5
Actin-related protein 5

1

10

High-throughput

0.479

High

1446348

DMAP1
DNA methyltransferase 1-associated protein 1

1

2

High-throughput

0.479

High

1449170

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.479

High

1452375

DDX56
Probable ATP-dependent RNA helicase DDX56

1

16

High-throughput

0.479

High

1454492

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

18

High-throughput

0.479

High

1454671

RCOR3
REST corepressor 3

1

17

High-throughput

0.479

High

1458838

ZMYM2
Zinc finger MYM-type protein 2

1

19

High-throughput

0.479

High

1459935

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.479

High

1460925

ING1
Inhibitor of growth protein 1

1

20

High-throughput

0.479

High

1461035

GMEB2
Glucocorticoid modulatory element-binding protein 2

1

11

High-throughput

0.479

High

1461148

RCOR1
REST corepressor 1

1

18

High-throughput

0.479

High

1461323

ZHX1
Zinc fingers and homeoboxes protein 1

1

20

High-throughput

0.479

High

1462041

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.479

High

1462736

SMC3
Structural maintenance of chromosomes protein 3

1

6

High-throughput

0.479

High

1491166

NOP16
Nucleolar protein 16

1

6

High-throughput

0.479

High

1491355

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

1491464

ZHX2
Zinc fingers and homeoboxes protein 2

1

19

High-throughput

0.479

High

47439

A0A6Q8PF08
Peripheral myelin protein 22

1

3

High-throughput

0.470

High

1011566

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.457

High

1415583

GNL3
Guanine nucleotide-binding protein-like 3

1

6

High-throughput

0.457

High

1419674

RM37
Large ribosomal subunit protein mL37

1

1

High-throughput

0.457

High

1490614

RT33
Small ribosomal subunit protein mS33

1

1

High-throughput

0.457

High

694097

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.445

High

317758

NOL4
Nucleolar protein 4

1

4

High-throughput

0.437

High

1012801

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.437

High

1048775

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

5

High-throughput

0.437

High

1112355

PWP1
Periodic tryptophan protein 1 homolog

1

20

High-throughput

0.437

High

1231696

RL7L
Ribosomal protein uL30-like

1

3

High-throughput

0.437

High

1392277

DDX27
Probable ATP-dependent RNA helicase DDX27

1

12

High-throughput

0.437

High

1407748

EBP2
Probable rRNA-processing protein EBP2

1

4

High-throughput

0.437

High

1411218

CHOLN
Protein cholesin

1

5

High-throughput

0.437

High

1411830

LLPH
Protein LLP homolog

1

1

High-throughput

0.437

High

1436311

DDX31
ATP-dependent DNA helicase DDX31

1

12

High-throughput

0.437

High

1439624

RM47
Large ribosomal subunit protein uL29m

1

1

High-throughput

0.437

High

1450746

DDX18
ATP-dependent RNA helicase DDX18

1

19

High-throughput

0.437

High

1462407

RL26L
Ribosomal protein uL24-like

1

12

High-throughput

0.437

High

1490870

RT28
Small ribosomal subunit protein bS1m

1

3

High-throughput

0.437

High

1490886

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.437

High

1491202

RT18C
Small ribosomal subunit protein bS18m

1

9

High-throughput

0.437

High

1335983

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.279

Low

1104174

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.261

Low

991966

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1491157

RRP15
RRP15-like protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025