Protein: KLF3
Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2)

Gene: KLF3
Organism: Homo sapiens
Interactions: 244
UniProt ID: P57682

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177450

ZN536
Zinc finger protein 536

2

20

High-throughput

0.754

High

229315

ZBT14
Zinc finger and BTB domain-containing protein 14

2

19

High-throughput

0.754

High

245606

ZEB2
Zinc finger E-box-binding homeobox 2

2

20

High-throughput

0.754

High

277162

ZN217
Zinc finger protein 217

2

20

High-throughput

0.754

High

586259

ZEP1
Zinc finger protein 40

2

20

High-throughput

0.754

High

790001

ZEB1
Zinc finger E-box-binding homeobox 1

2

20

High-throughput

0.754

High

944630

MECOM
Histone-lysine N-methyltransferase MECOM

2

19

High-throughput

0.754

High

944645

PRDM2
PR domain zinc finger protein 2

2

19

High-throughput

0.754

High

944747

PRD16
Histone-lysine N-methyltransferase PRDM16

2

18

High-throughput

0.754

High

944650

FHL3
Four and a half LIM domains protein 3

7

16

Small-scale

0.754

High

941384

CTBP2
C-terminal-binding protein 2

6

14

Small-scale

0.729

High

944649

CTBP1
C-terminal-binding protein 1

4

14

High-throughput

0.699

High

944644

TRAF2
TNF receptor-associated factor 2

4

20

High-throughput

0.698

High

944723

EHMT2
Histone-lysine N-methyltransferase EHMT2

4

20

High-throughput

0.685

High

167246

KLF11
Krueppel-like factor 11

1

19

High-throughput

0.665

High

927204

ATX1
Ataxin-1

3

9

High-throughput

0.650

High

142922

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.634

High

944642

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.634

High

944682

LHX8
LIM/homeobox protein Lhx8

2

10

High-throughput

0.628

High

473894

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.624

High

786045

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.618

High

944646

RLF
Zinc finger protein Rlf

1

17

High-throughput

0.618

High

944661

ZFHX3
Zinc finger homeobox protein 3

1

17

High-throughput

0.618

High

944669

ZN423
Zinc finger protein 423

1

14

High-throughput

0.618

High

944680

TSH3
Teashirt homolog 3

1

17

High-throughput

0.618

High

944711

ZN516
Zinc finger protein 516

1

19

High-throughput

0.618

High

944712

RREB1
Ras-responsive element-binding protein 1

1

20

High-throughput

0.618

High

944737

BC11A
BCL11 transcription factor A

1

18

High-throughput

0.618

High

944742

ZN644
Zinc finger protein 644

1

18

High-throughput

0.618

High

944768

ZN148
Zinc finger protein 148

1

19

High-throughput

0.618

High

944770

ZN281
Zinc finger protein 281

1

19

High-throughput

0.618

High

733241

OTX2
Homeobox protein OTX2

2

8

High-throughput

0.606

High

944766

LHX6
LIM/homeobox protein Lhx6

2

10

High-throughput

0.606

High

944677

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

1

High-throughput

0.601

High

246505

KDM1A
Lysine-specific histone demethylase 1A

2

9

High-throughput

0.600

High

297531

PIAS1
E3 SUMO-protein ligase PIAS1

2

2

High-throughput

0.586

High

161442

KMT2D
Histone-lysine N-methyltransferase 2D

2

20

High-throughput

0.584

High

174334

ZN609
Zinc finger protein 609

2

16

High-throughput

0.584

High

194539

KDM6A
Lysine-specific demethylase 6A

2

14

High-throughput

0.584

High

282691

E2F6
Transcription factor E2F6

2

9

High-throughput

0.584

High

283451

TAD2A
Transcriptional adapter 2-alpha

2

16

High-throughput

0.584

High

297779

PIAS2
E3 SUMO-protein ligase PIAS2

2

2

High-throughput

0.584

High

344907

WIZ
Protein Wiz

2

20

High-throughput

0.584

High

505541

ATX1L
Ataxin-1-like

2

9

High-throughput

0.584

High

559746

NR2C1
Nuclear receptor subfamily 2 group C member 1

2

20

High-throughput

0.584

High

776040

SOX5
Transcription factor SOX-5

2

20

High-throughput

0.584

High

878853

NR2C2
Nuclear receptor subfamily 2 group C member 2

2

20

High-throughput

0.584

High

944627

FOXK1
Forkhead box protein K1

2

17

High-throughput

0.584

High

944631

KMT2A
Histone-lysine N-methyltransferase 2A

2

20

High-throughput

0.584

High

944635

MBTD1
MBT domain-containing protein 1

2

13

High-throughput

0.584

High

944637

RING1
E3 ubiquitin-protein ligase RING1

2

20

High-throughput

0.584

High

944640

EP300
Histone acetyltransferase p300

2

20

High-throughput

0.584

High

944655

ARI5B
AT-rich interactive domain-containing protein 5B

2

20

High-throughput

0.584

High

944671

ARI4B
AT-rich interactive domain-containing protein 4B

2

20

High-throughput

0.584

High

944676

BRM1L
Breast cancer metastasis-suppressor 1-like protein

2

12

High-throughput

0.584

High

944678

TAF3
Transcription initiation factor TFIID subunit 3

2

20

High-throughput

0.584

High

944679

ZMYM4
Zinc finger MYM-type protein 4

2

20

High-throughput

0.584

High

944681

ARID2
AT-rich interactive domain-containing protein 2

2

20

High-throughput

0.584

High

944684

LIN54
Protein lin-54 homolog

2

4

High-throughput

0.584

High

944716

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

14

High-throughput

0.573

High

944740

CPVL
Probable serine carboxypeptidase CPVL

2

5

High-throughput

0.558

High

705290

GRN
Progranulin

2

3

High-throughput

0.549

High

944628

TFAM
Transcription factor A, mitochondrial

1

20

High-throughput

0.536

High

317717

NOL4
Nucleolar protein 4

2

5

High-throughput

0.533

High

59219

A2ABF9
[histone H3]-lysine(9) N-methyltransferase

1

20

High-throughput

0.515

High

301383

WFS1
Wolframin

1

4

High-throughput

0.515

High

374505

RASH
GTPase HRas

1

6

High-throughput

0.515

High

384392

CRYAA
Alpha-crystallin A chain

1

6

High-throughput

0.515

High

843432

HD
Huntingtin

1

9

High-throughput

0.515

High

856613

BAG6
Large proline-rich protein BAG6

1

20

High-throughput

0.515

High

944715

KLK6
Kallikrein-6

1

3

High-throughput

0.515

High

944743

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

18

High-throughput

0.508

High

894654

EMD
Emerin

1

9

High-throughput

0.500

High

944623

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

7

High-throughput

0.500

High

944675

PREP
Presequence protease, mitochondrial

1

3

High-throughput

0.500

High

216655

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

944769

CSEN
Calsenilin

1

0

High-throughput

0.493

High

944634

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

4

High-throughput

0.489

High

944625

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.481

High

67989

SOBP
Sine oculis-binding protein homolog

1

20

High-throughput

0.479

High

130724

TAF4
Transcription initiation factor TFIID subunit 4

1

12

High-throughput

0.479

High

154660

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

175865

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

High-throughput

0.479

High

178484

TBX3
T-box transcription factor TBX3

1

12

High-throughput

0.479

High

180760

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

243582

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.479

High

278289

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

284815

TADA3
Transcriptional adapter 3

1

5

High-throughput

0.479

High

284935

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

17

High-throughput

0.479

High

488436

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

High-throughput

0.479

High

555363

SKI
Ski oncogene

1

3

High-throughput

0.479

High

624234

TFE3
Transcription factor E3

1

16

High-throughput

0.479

High

633303

MSH3
DNA mismatch repair protein Msh3

1

1

High-throughput

0.479

High

639699

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.479

High

697821

CALR
Calreticulin

1

3

High-throughput

0.479

High

711754

ARI4A
AT-rich interactive domain-containing protein 4A

1

20

High-throughput

0.479

High

711804

KDM5A
Lysine-specific demethylase 5A

1

7

High-throughput

0.479

High

738963

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

766362

PHB1
Prohibitin 1

1

6

High-throughput

0.479

High

903113

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

High-throughput

0.479

High

913750

ZN131
Zinc finger protein 131

1

20

High-throughput

0.479

High

926636

HIRA
Protein HIRA

1

10

High-throughput

0.479

High

944620

DCAF7
DDB1- and CUL4-associated factor 7

1

8

High-throughput

0.479

High

944621

WDR5
WD repeat-containing protein 5

1

13

High-throughput

0.479

High

944629

FOXK2
Forkhead box protein K2

1

13

High-throughput

0.479

High

944632

TLE1
Transducin-like enhancer protein 1

1

18

High-throughput

0.479

High

944633

TLE3
Transducin-like enhancer protein 3

1

18

High-throughput

0.479

High

944636

GABPA
GA-binding protein alpha chain

1

20

High-throughput

0.479

High

944638

TLE5
TLE family member 5

1

12

High-throughput

0.479

High

944641

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

944643

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

18

High-throughput

0.479

High

944647

TBX2
T-box transcription factor TBX2

1

12

High-throughput

0.479

High

944651

TFDP1
Transcription factor Dp-1

1

3

High-throughput

0.479

High

944652

ZMYM3
Zinc finger MYM-type protein 3

1

20

High-throughput

0.479

High

944654

MEF2D
Myocyte-specific enhancer factor 2D

1

5

High-throughput

0.479

High

944656

RBBP5
Retinoblastoma-binding protein 5

1

13

High-throughput

0.479

High

944657

SSXT
Protein SSXT

1

15

High-throughput

0.479

High

944659

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

944660

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

5

High-throughput

0.479

High

944662

TAF12
Transcription initiation factor TFIID subunit 12

1

3

High-throughput

0.479

High

944663

TAF9
Transcription initiation factor TFIID subunit 9

1

6

High-throughput

0.479

High

944667

RFX7
DNA-binding protein RFX7

1

10

High-throughput

0.479

High

944670

PCGF3
Polycomb group RING finger protein 3

1

20

High-throughput

0.479

High

944673

EPC2
Enhancer of polycomb homolog 2

1

10

High-throughput

0.479

High

944674

BCORL
BCL-6 corepressor-like protein 1

1

11

High-throughput

0.479

High

944683

NIPBL
Nipped-B-like protein

1

17

High-throughput

0.479

High

944685

NFRKB
Nuclear factor related to kappa-B-binding protein

1

16

High-throughput

0.479

High

944686

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

13

High-throughput

0.479

High

944687

MCAF1
Activating transcription factor 7-interacting protein 1

1

18

High-throughput

0.479

High

944688

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

944689

UBN2
Ubinuclein-2

1

20

High-throughput

0.479

High

944690

POGZ
Pogo transposable element with ZNF domain

1

20

High-throughput

0.479

High

944691

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

High-throughput

0.479

High

944692

I2BP2
Interferon regulatory factor 2-binding protein 2

1

7

High-throughput

0.479

High

944693

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.479

High

944694

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

944696

P66A
Transcriptional repressor p66-alpha

1

4

High-throughput

0.479

High

944697

I2BP1
Interferon regulatory factor 2-binding protein 1

1

4

High-throughput

0.479

High

944698

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

944699

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

944700

MGAP
MAX gene-associated protein

1

12

High-throughput

0.479

High

944701

YAF2
YY1-associated factor 2

1

4

High-throughput

0.479

High

944702

ZZZ3
ZZ-type zinc finger-containing protein 3

1

2

High-throughput

0.479

High

944703

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.479

High

944705

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

944706

KDM2B
Lysine-specific demethylase 2B

1

11

High-throughput

0.479

High

944707

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

18

High-throughput

0.479

High

944708

MORC4
MORC family CW-type zinc finger protein 4

1

2

High-throughput

0.479

High

944709

GATD1
GATA zinc finger domain-containing protein 1

1

5

High-throughput

0.479

High

944710

P66B
Transcriptional repressor p66-beta

1

4

High-throughput

0.479

High

944713

KAT2A
Histone acetyltransferase KAT2A

1

20

High-throughput

0.479

High

944714

KAT2B
Histone acetyltransferase KAT2B

1

20

High-throughput

0.479

High

944718

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

13

High-throughput

0.479

High

944719

PF21A
PHD finger protein 21A

1

20

High-throughput

0.479

High

944720

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

19

High-throughput

0.479

High

944721

MBD6
Methyl-CpG-binding domain protein 6

1

9

High-throughput

0.479

High

944722

SGF29
SAGA-associated factor 29

1

1

High-throughput

0.479

High

944724

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

944725

PHF12
PHD finger protein 12

1

20

High-throughput

0.479

High

944726

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

944727

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

944728

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

944729

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

944730

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

944733

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

944734

SP130
Histone deacetylase complex subunit SAP130

1

19

High-throughput

0.479

High

944736

ING2
Inhibitor of growth protein 2

1

20

High-throughput

0.479

High

944738

EPC1
Enhancer of polycomb homolog 1

1

10

High-throughput

0.479

High

944739

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

944741

ZHX3
Zinc fingers and homeoboxes protein 3

1

20

High-throughput

0.479

High

944744

CSR2B
Cysteine-rich protein 2-binding protein

1

2

High-throughput

0.479

High

944745

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

18

High-throughput

0.479

High

944748

TAF9B
Transcription initiation factor TFIID subunit 9B

1

6

High-throughput

0.479

High

944750

SHCAF
SIN3-HDAC complex-associated factor

1

3

High-throughput

0.479

High

944751

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

944752

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.479

High

944755

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

944756

ZMYM2
Zinc finger MYM-type protein 2

1

20

High-throughput

0.479

High

944757

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

944758

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.479

High

944759

ING1
Inhibitor of growth protein 1

1

20

High-throughput

0.479

High

944760

GMEB2
Glucocorticoid modulatory element-binding protein 2

1

11

High-throughput

0.479

High

944761

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

944762

ZHX1
Zinc fingers and homeoboxes protein 1

1

20

High-throughput

0.479

High

944763

ZN608
Zinc finger protein 608

1

8

High-throughput

0.479

High

944764

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.479

High

944773

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

944774

ZHX2
Zinc fingers and homeoboxes protein 2

1

20

High-throughput

0.479

High

231692

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.470

High

245900

KIF1B
Kinesin-like protein KIF1B

1

5

High-throughput

0.470

High

415468

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.470

High

650109

FGFR3
Fibroblast growth factor receptor 3

1

6

High-throughput

0.470

High

944619

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.470

High

944695

Q86V38
Atrophin 1

1

15

High-throughput

0.470

High

944732

NUP58
Nucleoporin p58/p45

1

1

High-throughput

0.470

High

944622

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

0

High-throughput

0.460

High

892534

DNLI3
DNA ligase 3

1

0

High-throughput

0.458

High

944639

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

944648

GPS2
G protein pathway suppressor 2

1

0

High-throughput

0.458

High

944658

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.458

High

944672

LIN52
Protein lin-52 homolog

1

0

High-throughput

0.458

High

944704

IN80E
INO80 complex subunit E

1

0

High-throughput

0.458

High

944735

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.458

High

944767

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.458

High

447726

TPM3
Tropomyosin alpha-3 chain

1

12

High-throughput

0.457

High

552547

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.457

High

944626

TPM4
Tropomyosin alpha-4 chain

1

11

High-throughput

0.457

High

944754

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

298692

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

2

High-throughput

0.437

High

317998

TOM70
Mitochondrial import receptor subunit TOM70

1

8

High-throughput

0.437

High

359627

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.437

High

390508

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.437

High

417350

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.437

High

420454

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

6

High-throughput

0.437

High

421815

A4
Amyloid-beta precursor protein

1

18

High-throughput

0.437

High

485855

COX6C
Cytochrome c oxidase subunit 6C

1

1

High-throughput

0.437

High

566607

PDIA4
Protein disulfide-isomerase A4

1

6

High-throughput

0.437

High

573410

ENPL
Endoplasmin

1

4

High-throughput

0.437

High

576099

CX6B1
Cytochrome c oxidase subunit 6B1

1

2

High-throughput

0.437

High

717421

PDIA3
Protein disulfide-isomerase A3

1

6

High-throughput

0.437

High

859754

RL28
Large ribosomal subunit protein eL28

1

7

High-throughput

0.437

High

903857

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.437

High

944653

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

944665

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

1

High-throughput

0.437

High

944666

MIC60
MICOS complex subunit MIC60

1

3

High-throughput

0.437

High

944668

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

944717

RL36L
Ribosomal protein eL42-like

1

10

High-throughput

0.437

High

944731

TMED9
Transmembrane emp24 domain-containing protein 9

1

5

High-throughput

0.437

High

944746

FBRS
Probable fibrosin-1

1

4

High-throughput

0.437

High

944749

FBSL
Fibrosin-1-like protein

1

4

High-throughput

0.437

High

944765

RL26L
Ribosomal protein uL24-like

1

12

High-throughput

0.437

High

944771

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.437

High

167588

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.268

Low

944753

DDIT4
DNA damage-inducible transcript 4 protein

1

0

High-throughput

0.268

Low

944772

BACE2
Beta-secretase 2

1

0

High-throughput

0.268

Low

91756

MCRI1
Mapk-regulated corepressor-interacting protein 1

1

0

High-throughput

0.249

Low

165553

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.249

Low

221210

DNPH1
5-hydroxymethyl-dUMP N-hydrolase

1

0

High-throughput

0.249

Low

458680

SAP
Prosaposin

1

0

High-throughput

0.249

Low

539311

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

0

High-throughput

0.249

Low

657361

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

906231

SSDH
Succinate-semialdehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

944624

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.249

Low

944664

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025