Protein: PRD16
Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)

Gene: PRD16, PRDM16
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q9HAZ2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

944747

KLF3
Krueppel-like factor 3

2

18

High-throughput

0.754

High

1365815

ZN516
Zinc finger protein 516

1

7

High-throughput

0.691

High

1103387

CTBP1
C-terminal-binding protein 1

4

8

High-throughput

0.683

High

331523

SPDEF
SAM pointed domain-containing Ets transcription factor

3

2

High-throughput

0.667

High

1165318

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

7

High-throughput

0.621

High

1437873

NEK6
Serine/threonine-protein kinase Nek6

1

4

High-throughput

0.621

High

1437883

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

20

High-throughput

0.621

High

299579

TRIO
Triple functional domain protein

1

2

High-throughput

0.618

High

538475

EGR2
E3 SUMO-protein ligase EGR2

1

18

High-throughput

0.618

High

625634

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.618

High

998037

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.618

High

1398079

ZN512
Zinc finger protein 512

1

19

High-throughput

0.618

High

1437871

PRD16
Histone-lysine N-methyltransferase PRDM16

1

8

High-throughput

0.618

High

1437892

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

941568

CTBP2
C-terminal-binding protein 2

2

8

High-throughput

0.611

High

1014622

SMAD3
Mothers against decapentaplegic homolog 3

2

14

Small-scale

0.601

High

1066499

RBBP4
Histone-binding protein RBBP4

1

4

High-throughput

0.597

High

136137

PLK4
Serine/threonine-protein kinase PLK4

1

0

High-throughput

0.589

High

1055276

MTG8
Protein CBFA2T1

1

0

High-throughput

0.589

High

1153917

SMAD2
Mothers against decapentaplegic homolog 2

2

14

Small-scale

0.584

High

555432

SKI
Ski oncogene

2

0

Small-scale

0.559

High

156346

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

3

High-throughput

0.536

High

983208

RS26
Small ribosomal subunit protein eS26

1

1

High-throughput

0.536

High

1315923

RCOR2
REST corepressor 2

1

7

High-throughput

0.536

High

1410600

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.536

High

1437884

RCOR1
REST corepressor 1

1

7

High-throughput

0.536

High

1162049

H31T
Histone H3.1t

1

14

High-throughput

0.515

High

1371701

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.501

High

762253

TRY3
Trypsin-3

1

1

High-throughput

0.489

High

1437874

S10AE
Protein S100-A14

1

6

High-throughput

0.489

High

1437880

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

2

High-throughput

0.489

High

684398

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.481

High

821202

TXLNA
Alpha-taxilin

1

8

High-throughput

0.481

High

882566

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.481

High

1400253

LENG8
Leukocyte receptor cluster member 8

1

1

High-throughput

0.481

High

1413268

TCHP
Trichoplein keratin filament-binding protein

1

4

High-throughput

0.481

High

123838

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.479

High

141119

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

143267

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.479

High

158326

COPE
Coatomer subunit epsilon

1

1

High-throughput

0.479

High

187802

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

High-throughput

0.479

High

210121

CRX
Cone-rod homeobox protein

1

5

High-throughput

0.479

High

211052

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

222532

PLRG1
Pleiotropic regulator 1

1

3

High-throughput

0.479

High

229081

AKAP8
A-kinase anchor protein 8

1

2

High-throughput

0.479

High

243740

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

5

High-throughput

0.479

High

274763

DNJB6
DnaJ homolog subfamily B member 6

1

8

High-throughput

0.479

High

277822

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.479

High

283145

PSIP1
PC4 and SFRS1-interacting protein

1

3

High-throughput

0.479

High

316997

MTA2
Metastasis-associated protein MTA2

1

7

High-throughput

0.479

High

352248

MBD3
Methyl-CpG-binding domain protein 3

1

2

High-throughput

0.479

High

417767

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

449793

H2B1J
Histone H2B type 1-J

1

3

High-throughput

0.479

High

457131

CAN1
Calpain-1 catalytic subunit

1

1

High-throughput

0.479

High

467615

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

471699

CY1
Cytochrome c1, heme protein, mitochondrial

1

1

High-throughput

0.479

High

474303

NFIC
Nuclear factor 1 C-type

1

18

High-throughput

0.479

High

487773

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

535555

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.479

High

539261

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.479

High

558417

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

559504

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.479

High

574036

HXB2
Homeobox protein Hox-B2

1

1

High-throughput

0.479

High

600940

HSP76
Heat shock 70 kDa protein 6

1

4

High-throughput

0.479

High

608940

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

3

High-throughput

0.479

High

665723

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

1

High-throughput

0.479

High

687731

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.479

High

732708

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.479

High

756354

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.479

High

770058

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.479

High

776253

SOX6
Transcription factor SOX-6

1

14

High-throughput

0.479

High

778785

PRS7
26S proteasome regulatory subunit 7

1

4

High-throughput

0.479

High

837095

ELK3
ETS domain-containing protein Elk-3

1

2

High-throughput

0.479

High

838789

MTREX
Exosome RNA helicase MTR4

1

5

High-throughput

0.479

High

859461

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

861296

MAP1B
Microtubule-associated protein 1B

1

5

High-throughput

0.479

High

862987

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.479

High

869987

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.479

High

900170

FXR1
RNA-binding protein FXR1

1

7

High-throughput

0.479

High

900520

FXR2
RNA-binding protein FXR2

1

7

High-throughput

0.479

High

911113

IMA1
Importin subunit alpha-1

1

7

High-throughput

0.479

High

921793

COPB
Coatomer subunit beta

1

1

High-throughput

0.479

High

922045

COPA
Coatomer subunit alpha

1

1

High-throughput

0.479

High

936864

NP1L1
Nucleosome assembly protein 1-like 1

1

6

High-throughput

0.479

High

942468

GSC
Homeobox protein goosecoid

1

8

High-throughput

0.479

High

949445

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

2

High-throughput

0.479

High

958198

ARP3
Actin-related protein 3

1

2

High-throughput

0.479

High

958353

ARP2
Actin-related protein 2

1

3

High-throughput

0.479

High

958514

ACTZ
Alpha-centractin

1

3

High-throughput

0.479

High

967562

RS7
Small ribosomal subunit protein eS7

1

2

High-throughput

0.479

High

968451

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.479

High

974476

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

High-throughput

0.479

High

987218

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.479

High

994382

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

7

High-throughput

0.479

High

995281

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

997143

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.479

High

998827

H31
Histone H3.1

1

14

High-throughput

0.479

High

1026233

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.479

High

1032547

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.479

High

1040215

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

3

High-throughput

0.479

High

1059967

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

High-throughput

0.479

High

1065437

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.479

High

1085712

TBL3
Transducin beta-like protein 3

1

4

High-throughput

0.479

High

1088031

NFIA
Nuclear factor 1 A-type

1

17

High-throughput

0.479

High

1097571

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1102658

MTA1
Metastasis-associated protein MTA1

1

7

High-throughput

0.479

High

1110094

HDAC1
Histone deacetylase 1

1

8

High-throughput

0.479

High

1114342

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1121747

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.479

High

1127172

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

1128290

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

1132985

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.479

High

1133673

NFIX
Nuclear factor 1 X-type

1

17

High-throughput

0.479

High

1136070

CND2
Condensin complex subunit 2

1

1

High-throughput

0.479

High

1159011

RBBP7
Histone-binding protein RBBP7

1

4

High-throughput

0.479

High

1163529

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

1

High-throughput

0.479

High

1192114

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

13

High-throughput

0.479

High

1210533

HP1B3
Heterochromatin protein 1-binding protein 3

1

1

High-throughput

0.479

High

1258952

H32
Histone H3.2

1

14

High-throughput

0.479

High

1272208

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

1

High-throughput

0.479

High

1290490

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

3

High-throughput

0.479

High

1295307

P66A
Transcriptional repressor p66-alpha

1

4

High-throughput

0.479

High

1323466

NUP93
Nuclear pore complex protein Nup93

1

1

High-throughput

0.479

High

1341028

THOC2
THO complex subunit 2

1

6

High-throughput

0.479

High

1359706

PHIP
PH-interacting protein

1

5

High-throughput

0.479

High

1361014

P66B
Transcriptional repressor p66-beta

1

4

High-throughput

0.479

High

1368132

HDAC2
Histone deacetylase 2

1

8

High-throughput

0.479

High

1371070

ARHG2
Rho guanine nucleotide exchange factor 2

1

3

High-throughput

0.479

High

1386704

AP2M1
AP-2 complex subunit mu

1

3

High-throughput

0.479

High

1389904

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.479

High

1399752

RBM14
RNA-binding protein 14

1

6

High-throughput

0.479

High

1403656

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

4

High-throughput

0.479

High

1404416

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.479

High

1405769

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.479

High

1413230

SOX7
Transcription factor SOX-7

1

11

High-throughput

0.479

High

1414196

TBB6
Tubulin beta-6 chain

1

1

High-throughput

0.479

High

1415541

GNL3
Guanine nucleotide-binding protein-like 3

1

3

High-throughput

0.479

High

1417308

AP1M1
AP-1 complex subunit mu-1

1

3

High-throughput

0.479

High

1429619

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.479

High

1430387

DDX47
Probable ATP-dependent RNA helicase DDX47

1

8

High-throughput

0.479

High

1433776

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.479

High

1435661

WDR26
WD repeat-containing protein 26

1

3

High-throughput

0.479

High

1437881

BAZ1B
Tyrosine-protein kinase BAZ1B

1

16

High-throughput

0.479

High

1437885

TPX2
Targeting protein for Xklp2

1

1

High-throughput

0.479

High

1437886

MAGD2
Melanoma-associated antigen D2

1

3

High-throughput

0.479

High

1437887

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

1437888

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.479

High

1437890

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

1437891

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.479

High

1437893

SP16H
FACT complex subunit SPT16

1

1

High-throughput

0.479

High

1437894

DDX49
Probable ATP-dependent RNA helicase DDX49

1

7

High-throughput

0.479

High

64832

BTBDH
BTB/POZ domain-containing protein 17

1

1

High-throughput

0.470

High

162124

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

High-throughput

0.460

High

654134

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.460

High

1350362

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.460

High

1407472

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.460

High

1414276

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.460

High

1415630

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.460

High

1437876

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.460

High

542228

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.458

High

589735

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

601866

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

696555

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769222

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1032051

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1391566

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.458

High

1419914

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.458

High

1437877

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.458

High

1437878

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.458

High

1314945

CCD13
Coiled-coil domain-containing protein 13

1

9

High-throughput

0.439

High

227975

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.437

High

420703

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.437

High

567083

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

High-throughput

0.437

High

598211

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

4

High-throughput

0.437

High

615445

SON
Protein SON

1

3

High-throughput

0.437

High

634184

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.437

High

829552

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

882898

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.437

High

1125064

RCN2
Reticulocalbin-2

1

6

High-throughput

0.437

High

1164578

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.437

High

1214799

ATD3B
ATPase family AAA domain-containing protein 3B

1

3

High-throughput

0.437

High

1437875

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.437

High

1437879

ABCF2
ATP-binding cassette sub-family F member 2

1

1

High-throughput

0.437

High

1437882

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

High-throughput

0.437

High

1437889

DLGP4
Disks large-associated protein 4

1

0

High-throughput

0.279

Low

1315385

CF206
Cilia- and flagella-associated protein 206

1

0

High-throughput

0.251

Low

1371198

GLMN
Glomulin

1

0

High-throughput

0.251

Low

137822

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

283979

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.249

Low

298810

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.249

Low

617604

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.249

Low

939830

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.249

Low

1437872

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025