HitPredict

Interactor 1: PRP19 (O14011)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Complexed with cdc5 protein 8) (RING-type E3 ubiquitin transferase PRP19)
Gene: PRP19

Interactor 2: SMD1 (O42661)
Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (snRNP core protein D1)
Gene: SMD1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21386897
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0071014 - post-mRNA release spliceosomal complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Sp			1 117
+	Hs
		911996 PRP19_HUMAN (1-487): 1.28e-115: 351: 25.69		RUXF_HUMAN (3-69): 1.72e-24: 90.4: 31.34
+	Sp
		144146 PRP19_SCHPO (1-488): 4.18e-104: 321: 96.95		SMD3_SCHPO (2-110): 3.05e-31: 108: 23.85
+	Sc
		692309 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		SMD3_YEAST (2-101): 3.61e-28: 100: 25.00
+	Sc
		692287 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		LSM2_YEAST (1-88): 5.11e-27: 97.3: 32.22
+	Sc
		692341 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		SMD1_YEAST (1-114): 2.03e-25: 94.6: 39.86
+	Hs
		912352 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		SMD1_HUMAN (1-96): 9.01e-35: 117: 78.13
+	Hs
		1288409 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		LSM4_HUMAN (1-83): 5.2e-34: 116: 27.38
+	Sc
		692303 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		LSM4_YEAST (1-98): 1.92e-16: 72.7: 23.85
+	Hs
		1288404 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		LSM2_HUMAN (1-94): 7.1e-34: 114: 29.17
+	Hs
		912701 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		SMD3_HUMAN (2-107): 7.27e-32: 110: 23.59
+	Hs
		911927 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		RUXF_HUMAN (3-69): 1.72e-24: 90.4: 31.34
+	Hs
		903091 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		SMD1_HUMAN (1-96): 9.01e-35: 117: 78.13
+	Hs
		903646 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		LSM4_HUMAN (1-83): 5.2e-34: 116: 27.38
+	Hs
		903627 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		LSM2_HUMAN (1-94): 7.1e-34: 114: 29.17
+	Hs
		903093 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		SMD3_HUMAN (2-107): 7.27e-32: 110: 23.59
+	Hs
		903090 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		RUXF_HUMAN (3-69): 1.72e-24: 90.4: 31.34
+	Sc
		589082 PRP4_YEAST (174-476): 8.43e-29: 120: 21.62		SMD3_YEAST (2-101): 3.61e-28: 100: 25.00
+	Sc
		589075 PRP4_YEAST (174-476): 8.43e-29: 120: 21.62		LSM2_YEAST (1-88): 5.11e-27: 97.3: 32.22
+	Sc
		589094 PRP4_YEAST (174-476): 8.43e-29: 120: 21.62		SMD1_YEAST (1-114): 2.03e-25: 94.6: 39.86
+	Sc
		589079 PRP4_YEAST (174-476): 8.43e-29: 120: 21.62		LSM4_YEAST (1-98): 1.92e-16: 72.7: 23.85