Protein: CO6A1
Collagen alpha-1(VI) chain

Gene: CO6A1, COL6A1
Organism: Homo sapiens
Interactions: 115
UniProt ID: P12109

Gene Ontology (top 5):
GO:0000302 - response to reactive oxygen species
GO:0000902 - cell morphogenesis
GO:0001649 - osteoblast differentiation
GO:0001942 - hair follicle development
GO:0002023 - reduction of food intake in response to dietary excess

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

505793

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

3

20

High-throughput

0.861

High

551756

CO9A1

3

17

High-throughput

0.861

High

551817

COL11
Collectin-11

3

18

High-throughput

0.861

High

551830

PRG3
Proteoglycan 3

2

6

High-throughput

0.776

High

73769

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.691

High

168366

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.691

High

388763

C1QC
Complement C1q subcomponent subunit C

1

20

High-throughput

0.691

High

551751

PRG2
Bone marrow proteoglycan

1

4

High-throughput

0.691

High

551761

CO8A2
Collagen alpha-2(VIII) chain

1

19

High-throughput

0.691

High

551818

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

20

High-throughput

0.691

High

551819

C1QT2
Complement C1q tumor necrosis factor-related protein 2

1

20

High-throughput

0.691

High

551829

COLQ
Acetylcholinesterase collagenic tail peptide

1

17

High-throughput

0.691

High

551786

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

2

High-throughput

0.667

High

469656

MMP2
72 kDa type IV collagenase

3

18

High-throughput

0.662

High

551805

LYPD1
Ly6/PLAUR domain-containing protein 1

3

1

High-throughput

0.662

High

458624

PGS2
Decorin

1

3

Small-scale

0.647

High

464409

TSP1
Thrombospondin-1

1

6

Small-scale

0.647

High

551759

PGS1
Biglycan

1

3

Small-scale

0.647

High

551766

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

19

Small-scale

0.647

High

551815

RTBDN
Retbindin

3

0

High-throughput

0.638

High

144076

WNT7A
Protein Wnt-7a

2

11

High-throughput

0.628

High

192057

PA2GX
Group 10 secretory phospholipase A2

2

2

High-throughput

0.628

High

551753

MMP9
Matrix metalloproteinase-9

2

18

High-throughput

0.628

High

551779

DEF1
Neutrophil defensin 1

2

3

High-throughput

0.628

High

551782

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

20

High-throughput

0.628

High

551798

LYZL1
Lysozyme-like protein 1

2

5

High-throughput

0.628

High

551832

INSL5
Insulin-like peptide INSL5

2

2

High-throughput

0.628

High

251851

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

2

20

High-throughput

0.601

High

298841

LYZL6
Lysozyme-like protein 6

2

5

High-throughput

0.601

High

551778

WNT4
Protein Wnt-4

2

11

High-throughput

0.601

High

551796

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

2

10

High-throughput

0.601

High

551757

CO5A1

1

18

Small-scale

0.590

High

342500

LY86
Lymphocyte antigen 86

2

0

High-throughput

0.576

High

551803

SFPA2
Pulmonary surfactant-associated protein A2

1

19

High-throughput

0.575

High

551827

FBX2
F-box only protein 2

2

7

High-throughput

0.549

High

376372

PDGFB
Platelet-derived growth factor subunit B

1

9

Small-scale

0.536

High

416588

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

1

High-throughput

0.536

High

506817

CFC1
Cryptic protein

1

1

High-throughput

0.536

High

551752

EDN3
Endothelin-3

1

1

High-throughput

0.536

High

551765

TIMP3
Metalloproteinase inhibitor 3

1

4

High-throughput

0.536

High

551769

WNT5A
Protein Wnt-5a

1

11

High-throughput

0.536

High

551773

VEGFB
Vascular endothelial growth factor B

1

9

High-throughput

0.536

High

551783

OS9
Protein OS-9

1

1

High-throughput

0.536

High

551787

EPHA7
Ephrin type-A receptor 7

1

2

High-throughput

0.536

High

551790

TAZ
Tafazzin

1

1

High-throughput

0.536

High

551791

CCL15
C-C motif chemokine 15

1

3

High-throughput

0.536

High

551792

DB136
Defensin beta 136

1

1

High-throughput

0.536

High

551793

DB135
Beta-defensin 135

1

1

High-throughput

0.536

High

551801

LYZL2
Lysozyme-like protein 2

1

5

High-throughput

0.536

High

551804

GT252
Procollagen galactosyltransferase 2

1

20

High-throughput

0.536

High

551806

DB125
Beta-defensin 125

1

1

High-throughput

0.536

High

551820

WN10A
Protein Wnt-10a

1

11

High-throughput

0.536

High

551822

IL25
Interleukin-25

1

1

High-throughput

0.536

High

551828

PA2GD
Group IID secretory phospholipase A2

1

2

High-throughput

0.536

High

551823

FBX6
F-box only protein 6

2

7

High-throughput

0.533

High

377384

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.513

High

485922

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.513

High

551755

NTF3
Neurotrophin-3

1

0

High-throughput

0.513

High

551768

LEP
Leptin

1

0

High-throughput

0.513

High

551776

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

551789

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

551808

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.513

High

551816

CNPY3
Protein canopy homolog 3

1

0

High-throughput

0.513

High

551825

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.508

High

403061

PDGFA
Platelet-derived growth factor subunit A

1

9

Small-scale

0.501

High

421404

A4
Amyloid-beta precursor protein

1

8

Small-scale

0.501

High

447968

ITAV
Integrin alpha-V

1

5

Small-scale

0.501

High

551758

MAG
Myelin-associated glycoprotein

1

5

Small-scale

0.501

High

551760

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

3

Small-scale

0.501

High

551762

LYOX
Protein-lysine 6-oxidase

1

1

Small-scale

0.501

High

551774

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.493

High

286519

SG2A1
Mammaglobin-B

1

1

High-throughput

0.489

High

303703

CYTF
Cystatin-F

1

1

High-throughput

0.489

High

551797

IGFL1
Insulin growth factor-like family member 1

1

1

High-throughput

0.489

High

551799

IGFL3
Insulin growth factor-like family member 3

1

1

High-throughput

0.489

High

551809

OIT3
Oncoprotein-induced transcript 3 protein

1

4

High-throughput

0.489

High

551826

KLF15
Krueppel-like factor 15

1

2

High-throughput

0.489

High

455947

ASGR2
Asialoglycoprotein receptor 2

1

0

High-throughput

0.481

High

551785

LRC32
Transforming growth factor beta activator LRRC32

1

0

High-throughput

0.481

High

136803

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

5

High-throughput

0.479

High

217764

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

551750

PDIA4
Protein disulfide-isomerase A4

1

6

High-throughput

0.479

High

551754

TIMP2
Metalloproteinase inhibitor 2

1

4

High-throughput

0.479

High

551763

PDIA3
Protein disulfide-isomerase A3

1

6

Small-scale

0.479

High

551764

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

551767

VHL
von Hippel-Lindau disease tumor suppressor

1

4

Small-scale

0.479

High

551772

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

551775

EFNA4
Ephrin-A4

1

1

High-throughput

0.479

High

551784

CUL3
Cullin-3

1

10

High-throughput

0.479

High

551795

KLF17
Krueppel-like factor 17

1

3

High-throughput

0.470

High

551770

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.458

High

551824

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

143726

WN10B
Protein Wnt-10b

1

11

High-throughput

0.445

High

167433

WNT9A
Protein Wnt-9a

1

11

High-throughput

0.445

High

191285

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

7

High-throughput

0.445

High

469702

MMP3
Stromelysin-1

1

15

High-throughput

0.445

High

551777

WNT3A
Protein Wnt-3a

1

11

High-throughput

0.445

High

551780

LYSC
Lysozyme C

1

5

High-throughput

0.445

High

551781

DEF5
Defensin alpha 5

1

3

High-throughput

0.445

High

551802

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.445

High

551810

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.445

High

551811

ESPB1
Epididymal sperm-binding protein 1

1

15

High-throughput

0.445

High

551813

HIPL1
HHIP-like protein 1

1

1

High-throughput

0.445

High

551831

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.445

High

105214

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

273305

SOCS5
Suppressor of cytokine signaling 5

1

1

Small-scale

0.437

High

551800

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

128578

AGRP
Agouti-related protein

1

0

High-throughput

0.426

High

551771

I12R1
Interleukin-12 receptor subunit beta-1

1

2

High-throughput

0.407

High

551807

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.407

High

551812

AURKB
Aurora kinase B

1

2

High-throughput

0.407

High

551788

CART

1

0

High-throughput

0.279

Low

551814

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.279

Low

551821

TWSG1
Twisted gastrulation protein homolog 1

1

0

High-throughput

0.279

Low

551794

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025