Protein: DGCR8
Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)

Gene: DGCR8
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q8WYQ5

Gene Ontology (top 5):
GO:0003725 - double-stranded RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1264668

RNC
Ribonuclease 3

13

1

Small-scale

0.982

High

269819

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

2

4

High-throughput

0.811

High

1254758

DDX54
ATP-dependent RNA helicase DDX54

2

4

High-throughput

0.811

High

1264628

DDX27
Probable ATP-dependent RNA helicase DDX27

2

4

High-throughput

0.811

High

1264654

DDX24
ATP-dependent RNA helicase DDX24

2

4

High-throughput

0.811

High

1264660

DDX31
ATP-dependent DNA helicase DDX31

2

5

High-throughput

0.811

High

1264670

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

2

4

High-throughput

0.811

High

1264677

DDX56
Probable ATP-dependent RNA helicase DDX56

2

4

High-throughput

0.811

High

1019851

ILF3
Interleukin enhancer-binding factor 3

2

1

Small-scale

0.789

High

1264621

DDX17
Probable ATP-dependent RNA helicase DDX17

2

2

Small-scale

0.737

High

1264617

DGCR8
Microprocessor complex subunit DGCR8

2

0

Small-scale

0.716

High

322933

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.691

High

1027915

DDX10
Probable ATP-dependent RNA helicase DDX10

1

5

High-throughput

0.691

High

1183954

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.691

High

1264638

DDX50
ATP-dependent RNA helicase DDX50

1

3

High-throughput

0.691

High

1264672

DDX18
ATP-dependent RNA helicase DDX18

1

6

High-throughput

0.691

High

1264634

SRPK1
SRSF protein kinase 1

3

1

High-throughput

0.690

High

773477

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.656

High

1264682

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

3

1

Small-scale

0.640

High

275744

ZN189
Zinc finger protein 189

2

2

High-throughput

0.628

High

485263

TZAP
Telomere zinc finger-associated protein

2

3

High-throughput

0.628

High

563495

ZNF22
Zinc finger protein 22

2

2

High-throughput

0.628

High

565096

ZNF7
Zinc finger protein 7

2

2

High-throughput

0.628

High

1103111

ZN800
Zinc finger protein 800

2

2

High-throughput

0.628

High

1115554

GLYR1
Cytokine-like nuclear factor N-PAC

2

1

High-throughput

0.628

High

1145693

LAR1B
La-related protein 1B

2

1

High-throughput

0.628

High

1149611

Z324B
Zinc finger protein 324B

2

4

High-throughput

0.628

High

1184515

ZN771
Zinc finger protein 771

2

1

High-throughput

0.628

High

1187687

ZCCHV
Zinc finger CCCH-type antiviral protein 1

2

2

High-throughput

0.628

High

1239544

ZFP62
Zinc finger protein 62 homolog

2

1

High-throughput

0.628

High

1242439

PAPD5
Terminal nucleotidyltransferase 4B

2

1

High-throughput

0.628

High

1255168

BRX1
Ribosome biogenesis protein BRX1 homolog

2

4

High-throughput

0.628

High

1257090

ZN483
Zinc finger protein 483

2

2

High-throughput

0.628

High

1264622

RENT1
Regulator of nonsense transcripts 1

2

1

High-throughput

0.628

High

1264626

ZN689
Zinc finger protein 689

2

2

High-throughput

0.628

High

1264631

ZN668
Zinc finger protein 668

2

2

High-throughput

0.628

High

1264647

REPI1
Replication initiator 1

2

4

High-throughput

0.628

High

1264649

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

2

High-throughput

0.628

High

1264663

MOV10
Helicase MOV-10

2

1

High-throughput

0.628

High

1264673

RBM28
RNA-binding protein 28

2

2

High-throughput

0.628

High

1264685

ZNF70
Zinc finger protein 70

2

1

High-throughput

0.628

High

1264690

ZN777
Zinc finger protein 777

2

3

High-throughput

0.628

High

571528

DDX5
Probable ATP-dependent RNA helicase DDX5

1

2

Small-scale

0.618

High

994267

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.618

High

942844

SRPK2
SRSF protein kinase 2

2

2

High-throughput

0.611

High

133189

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

2

0

High-throughput

0.602

High

177523

NVL
Nuclear valosin-containing protein-like

2

0

High-throughput

0.602

High

196147

RRP8
Ribosomal RNA-processing protein 8

2

0

High-throughput

0.602

High

242522

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

2

0

High-throughput

0.602

High

273188

SURF6
Surfeit locus protein 6

2

0

High-throughput

0.602

High

315397

NSA2
Ribosome biogenesis protein NSA2 homolog

2

0

High-throughput

0.602

High

331855

NSD2
Histone-lysine N-methyltransferase NSD2

2

0

High-throughput

0.602

High

400610

RLA2
Large ribosomal subunit protein P2

2

0

High-throughput

0.602

High

578048

RL17
Large ribosomal subunit protein uL22

2

0

High-throughput

0.602

High

802165

NOP2
Probable 28S rRNA

2

0

High-throughput

0.602

High

848097

MECP2
Methyl-CpG-binding protein 2

2

0

High-throughput

0.602

High

911198

RS13
Small ribosomal subunit protein uS15

2

0

High-throughput

0.602

High

975509

CENPC
Centromere protein C

2

0

High-throughput

0.602

High

1045646

NOG2
Nucleolar GTP-binding protein 2

2

0

High-throughput

0.602

High

1071737

TTF1
Transcription termination factor 1

2

0

High-throughput

0.602

High

1073234

PUM3
Pumilio homolog 3

2

0

High-throughput

0.602

High

1092593

KNOP1
Lysine-rich nucleolar protein 1

2

0

High-throughput

0.602

High

1161559

SHQ1
Protein SHQ1 homolog

2

0

High-throughput

0.602

High

1162429

CC137
Coiled-coil domain-containing protein 137

2

0

High-throughput

0.602

High

1174715

CENPU
Centromere protein U

2

0

High-throughput

0.602

High

1184456

CENPQ
Centromere protein Q

2

0

High-throughput

0.602

High

1216237

H2A2B
Histone H2A type 2-B

2

0

High-throughput

0.602

High

1222346

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

0

High-throughput

0.602

High

1259491

NOC3L
Nucleolar complex protein 3 homolog

2

0

High-throughput

0.602

High

1264618

CENPI
Centromere protein I

2

0

High-throughput

0.602

High

1264629

CENPN
Centromere protein N

2

0

High-throughput

0.602

High

1264648

MAK16
Protein MAK16 homolog

2

0

High-throughput

0.602

High

1264650

GTPB4
GTP-binding protein 4

2

0

High-throughput

0.602

High

1264653

REXO4
RNA exonuclease 4

2

0

High-throughput

0.602

High

1264659

RPF2
Ribosome production factor 2 homolog

2

0

High-throughput

0.602

High

1264662

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

0

High-throughput

0.602

High

1264674

PK1IP
p21-activated protein kinase-interacting protein 1

2

0

High-throughput

0.602

High

1264689

RALY
RNA-binding protein Raly

2

0

High-throughput

0.602

High

950838

ERH
Enhancer of rudimentary homolog

2

0

High-throughput

0.585

High

1056906

MDC1
Mediator of DNA damage checkpoint protein 1

2

1

Small-scale

0.584

High

370104

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1174025

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

1

Small-scale

0.561

High

1264623

FUBP2
Far upstream element-binding protein 2

2

0

Small-scale

0.559

High

1220242

DHX40
Probable ATP-dependent RNA helicase DHX40

1

1

High-throughput

0.553

High

474032

PAB4L
Polyadenylate-binding protein 4-like

2

1

High-throughput

0.552

High

838172

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.549

High

1223719

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.537

High

164312

ZN646
Zinc finger protein 646

1

2

High-throughput

0.536

High

316945

KLF8
Krueppel-like factor 8

1

2

High-throughput

0.536

High

789494

RBM34
RNA-binding protein 34

1

1

High-throughput

0.536

High

831011

CTCF
Transcriptional repressor CTCF

1

3

High-throughput

0.536

High

880028

RRP1
Ribosomal RNA processing protein 1 homolog A

1

1

High-throughput

0.536

High

883296

PRD15
PR domain zinc finger protein 15

1

2

High-throughput

0.536

High

1029022

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.536

High

1042164

CUL3
Cullin-3

1

1

High-throughput

0.536

High

1057562

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.536

High

1139508

TUT7
Terminal uridylyltransferase 7

1

1

High-throughput

0.536

High

1153206

ZN770
Zinc finger protein 770

1

2

High-throughput

0.536

High

1162623

LARP1
La-related protein 1

1

1

High-throughput

0.536

High

1243206

NGDN
Neuroguidin

1

1

High-throughput

0.536

High

1264627

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.536

High

1264633

ZN512
Zinc finger protein 512

1

3

High-throughput

0.536

High

1264635

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.536

High

1264641

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.536

High

1264645

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

High-throughput

0.536

High

1264655

GZF1
GDNF-inducible zinc finger protein 1

1

3

High-throughput

0.536

High

1264656

E41LB
Band 4.1-like protein 4B

1

1

High-throughput

0.536

High

1264661

RPF1
Ribosome production factor 1

1

2

High-throughput

0.536

High

1264664

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.536

High

1264667

SAS10
Something about silencing protein 10

1

1

High-throughput

0.536

High

1264679

CDK12
Cyclin-dependent kinase 12

1

1

High-throughput

0.536

High

1264683

ZN624
Zinc finger protein 624

1

1

High-throughput

0.536

High

1264688

HERC5
E3 ISG15--protein ligase HERC5

1

1

High-throughput

0.536

High

1264696

FCF1
rRNA-processing protein FCF1 homolog

1

1

High-throughput

0.536

High

1264697

RBMX2
RNA-binding motif protein, X-linked 2

1

1

High-throughput

0.536

High

1264702

RBM19
Probable RNA-binding protein 19

1

2

High-throughput

0.536

High

1264703

TLN2
Talin-2

1

2

High-throughput

0.536

High

133590

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

172486

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.513

High

180396

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.513

High

308001

ZWINT
ZW10 interactor

1

0

High-throughput

0.513

High

568516

SYN1
Synapsin-1

1

0

High-throughput

0.513

High

641870

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.513

High

736617

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

855698

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

907426

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

913657

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.513

High

916290

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.513

High

922644

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.513

High

960546

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.513

High

1032255

CENPR
Centromere protein R

1

0

High-throughput

0.513

High

1058128

BMS1
Ribosome biogenesis protein BMS1 homolog

1

0

High-throughput

0.513

High

1065845

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.513

High

1076076

OASL
2'-5'-oligoadenylate synthase-like protein

1

0

High-throughput

0.513

High

1129772

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.513

High

1131367

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1147770

SPT2
Protein SPT2 homolog

1

0

High-throughput

0.513

High

1150332

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.513

High

1160952

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.513

High

1164133

WDR74
WD repeat-containing protein 74

1

0

High-throughput

0.513

High

1216944

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

0

High-throughput

0.513

High

1232759

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

0

High-throughput

0.513

High

1263290

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

0

High-throughput

0.513

High

1264620

TFG
Protein TFG

1

0

High-throughput

0.513

High

1264625

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.513

High

1264630

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.513

High

1264632

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1264636

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.513

High

1264639

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1264642

TRI56
E3 ubiquitin-protein ligase TRIM56

1

0

High-throughput

0.513

High

1264643

NOL10
Nucleolar protein 10

1

0

High-throughput

0.513

High

1264644

CENPO
Centromere protein O

1

0

High-throughput

0.513

High

1264652

WDR12
Ribosome biogenesis protein WDR12

1

0

High-throughput

0.513

High

1264657

CENPH
Centromere protein H

1

0

High-throughput

0.513

High

1264658

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.513

High

1264666

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.513

High

1264669

KIF15
Kinesin-like protein KIF15

1

0

High-throughput

0.513

High

1264671

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.513

High

1264675

KCTD5
BTB/POZ domain-containing protein KCTD5

1

0

High-throughput

0.513

High

1264676

AATF
Protein AATF

1

0

High-throughput

0.513

High

1264680

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.513

High

1264681

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.513

High

1264684

FBLN5
Fibulin-5

1

0

High-throughput

0.513

High

1264687

RLP24
Probable ribosome biogenesis protein RLP24

1

0

High-throughput

0.513

High

1264692

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1264695

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.513

High

1264699

NOP16
Nucleolar protein 16

1

0

High-throughput

0.513

High

1264700

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.513

High

395344

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

92278

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

202229

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

Small-scale

0.479

High

347454

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

379662

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

442348

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

455706

PARP1
Poly [ADP-ribose] polymerase 1

1

2

Small-scale

0.479

High

497356

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.479

High

502379

BIP
Endoplasmic reticulum chaperone BiP

1

1

Small-scale

0.479

High

523902

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

525000

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

582408

NUCL
Nucleolin

1

1

Small-scale

0.479

High

682912

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

Small-scale

0.479

High

718054

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

726958

FUS
RNA-binding protein FUS

1

1

Small-scale

0.479

High

794286

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.479

High

818304

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

855518

MSH6
DNA mismatch repair protein Msh6

1

2

Small-scale

0.479

High

962248

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

Small-scale

0.479

High

967302

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

1019042

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1188631

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1221606

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1264619

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1264691

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.479

High

1264701

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

2

Small-scale

0.479

High

125604

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

154221

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.458

High

282700

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

Small-scale

0.458

High

387201

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

504481

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

517384

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

651811

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.458

High

659013

MK01
Mitogen-activated protein kinase 1

1

0

High-throughput

0.458

High

669432

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.458

High

760202

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

764402

FEN1
Flap endonuclease 1

1

0

Small-scale

0.458

High

790833

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.458

High

943872

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.458

High

944348

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

1082301

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

1121416

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.458

High

1199075

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

Small-scale

0.458

High

1263204

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

1264624

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

1264637

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1264646

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1264651

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1264678

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1264686

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1264693

PRP19
Pre-mRNA-processing factor 19

1

0

Small-scale

0.458

High

66834

A8KAG1
G patch domain-containing protein 4

1

1

High-throughput

0.445

High

1085617

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.426

High

1245617

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.426

High

1264694

RL26L
Ribosomal protein uL24-like

2

0

High-throughput

0.318

High

330397

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

1054872

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1237250

BEND7
BEN domain-containing protein 7

1

0

High-throughput

0.279

Low

1254571

RS4Y2
Small ribosomal subunit protein eS4, Y isoform 2

1

0

High-throughput

0.279

Low

1264640

CG050
Uncharacterized protein C7orf50

1

0

High-throughput

0.279

Low

1264665

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.279

Low

1264698

RRP15
RRP15-like protein

1

0

High-throughput

0.279

Low

1233599

ARL14
ADP-ribosylation factor-like protein 14

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024