HitPredict

Interactor 1: UBL1 (O14399)
Ubiquitin-like protein 1
Gene: UBL1

Interactor 2: CUL3 (Q09760)
Cullin-3 (Cul-3)
Gene: CUL3

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	14527422, 11504566
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 78 Sp			1 785
+	Hs
		923983 RS27A_HUMAN (1-77): 9.47e-37: 122: 53.25		CUL3_HUMAN (2-785): 0: 803: 35.97
+	Hs
		1041658 NEDD8_HUMAN (1-76): 5.41e-34: 112: 81.58		CUL3_HUMAN (2-785): 0: 803: 35.97
+	Hs
		923984 RS27A_HUMAN (1-77): 9.47e-37: 122: 53.25		CUL4A_HUMAN (1-785): 0: 792: 31.89
+	Hs
		924296 RL40_HUMAN (1-76): 5.25e-34: 114: 53.95		CUL4A_HUMAN (1-785): 0: 792: 31.89
+	Hs
		1043010 NEDD8_HUMAN (1-76): 5.41e-34: 112: 81.58		CUL4A_HUMAN (1-785): 0: 792: 31.89
+	Hs
		923985 RS27A_HUMAN (1-77): 9.47e-37: 122: 53.25		CUL4B_HUMAN (1-785): 0: 781: 31.26
+	At
		1352191 RUB1_ARATH (3-76): 2.92e-27: 97.9: 82.43		CUL3A_ARATH (2-785): 0: 798: 34.73
+	Hs
		1043371 NEDD8_HUMAN (1-76): 5.41e-34: 112: 81.58		CUL4B_HUMAN (1-785): 0: 781: 31.26
+	Hs
		475024 UBB_HUMAN (1-76): 1.13e-31: 111: 53.95		CUL4B_HUMAN (1-785): 0: 781: 31.26
+	At
		1321116 RUB1_ARATH (3-76): 2.92e-27: 97.9: 82.43		CUL3B_ARATH (14-785): 0: 788: 35.66
+	Dm
		1213846 NEDD8_DROME (1-77): 1.01e-34: 114: 80.52		Q8IP45_DROME (10-785): 0: 766: 35.89
+	Hs
		1041004 NEDD8_HUMAN (1-76): 5.41e-34: 112: 81.58		CUL1_HUMAN (10-785): 0: 721: 26.12
+	At
		1091919 UBQ3_ARATH (1-76): 4.9e-30: 109: 52.63		CUL1_ARATH (15-785): 0: 719: 28.21
+	Ce
		1088883 NEDD8_CAEEL (1-76): 4.65e-35: 115: 82.90		CUL3_CAEEL (6-785): 0: 708: 31.99
+	At
		1277343 RUB1_ARATH (3-76): 2.92e-27: 97.9: 82.43		CUL1_ARATH (15-785): 0: 719: 28.21
+	At
		1247030 RUB2_ARATH (3-76): 3.77e-26: 95.2: 82.43		CUL1_ARATH (15-785): 0: 719: 28.21
+	Dm
		1097203 NEDD8_DROME (1-77): 1.01e-34: 114: 80.52		CUL1_DROME (16-785): 0: 679: 26.39
+	Hs
		1041337 NEDD8_HUMAN (1-76): 5.41e-34: 112: 81.58		CUL2_HUMAN (13-785): 0: 671: 23.51
+	Sp
		142907 UBL1_SCHPO (1-78): 1.56e-33: 111: 100.00		CUL1_SCHPO (17-785): 0: 653: 24.81
+	Hs
		1079566 NEDD8_HUMAN (1-76): 5.41e-34: 112: 81.58		CUL5_HUMAN (19-785): 0: 592: 21.19