Protein: CREST
Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)

Gene: CREST, SS18L1
Organism: Homo sapiens
Interactions: 107
UniProt ID: O75177

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273986

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

3

20

Small-scale

0.870

High

273985

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

2

20

High-throughput

0.754

High

274002

SF3B4
Splicing factor 3B subunit 4

4

1

High-throughput

0.705

High

274036

REQU
Zinc finger protein ubi-d4

4

20

High-throughput

0.699

High

274040

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

4

13

High-throughput

0.699

High

273961

CREST
Calcium-responsive transactivator

1

17

High-throughput

0.698

High

274035

DPF3
Zinc finger protein DPF3

4

20

High-throughput

0.694

High

274042

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

4

20

High-throughput

0.694

High

274024

SMRC2
SWI/SNF complex subunit SMARCC2

3

20

High-throughput

0.667

High

274018

RFX6
DNA-binding protein RFX6

3

0

High-throughput

0.639

High

273973

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

1

High-throughput

0.633

High

274028

BCL7C
B-cell CLL/lymphoma 7 protein family member C

2

15

High-throughput

0.628

High

274003

SSXT
Protein SSXT

1

18

High-throughput

0.618

High

274021

MISSL
MAPK-interacting and spindle-stabilizing protein-like

3

5

High-throughput

0.616

High

154590

ARI1A
AT-rich interactive domain-containing protein 1A

2

20

High-throughput

0.611

High

274023

ARI1B
AT-rich interactive domain-containing protein 1B

2

20

High-throughput

0.611

High

274034

DPF1
Zinc finger protein neuro-d4

2

20

High-throughput

0.611

High

273992

PAX8
Paired box protein Pax-8

2

16

High-throughput

0.606

High

274010

BICRL
BRD4-interacting chromatin-remodeling complex-associated protein-like

2

10

High-throughput

0.606

High

274022

ZMIZ2
Zinc finger MIZ domain-containing protein 2

2

7

High-throughput

0.606

High

274048

SSBP3
Single-stranded DNA-binding protein 3

2

11

High-throughput

0.606

High

273994

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

2

9

Small-scale

0.601

High

273962

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

274044

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

High-throughput

0.580

High

273976

LEG3
Galectin-3

1

4

High-throughput

0.573

High

273980

CSTF2
Cleavage stimulation factor subunit 2

1

1

High-throughput

0.573

High

274005

BCL7A
B-cell CLL/lymphoma 7 protein family member A

2

15

High-throughput

0.571

High

274037

CBP
CREB-binding protein

1

20

Small-scale

0.561

High

273998

TNK1
Non-receptor tyrosine-protein kinase TNK1

2

7

High-throughput

0.553

High

274015

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

1

High-throughput

0.553

High

169350

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

4

High-throughput

0.541

High

273963

BRD1
Bromodomain-containing protein 1

1

20

High-throughput

0.541

High

273977

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

High-throughput

0.541

High

273982

TCF7
Transcription factor 7

1

20

High-throughput

0.541

High

273983

STAT3
Signal transducer and activator of transcription 3

1

5

High-throughput

0.541

High

273989

HDAC4
Histone deacetylase 4

1

16

High-throughput

0.541

High

273991

SMAD3
Mothers against decapentaplegic homolog 3

1

6

High-throughput

0.541

High

273997

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.541

High

274004

SMAD1
Mothers against decapentaplegic homolog 1

1

6

High-throughput

0.541

High

274033

HDAC2
Histone deacetylase 2

1

13

High-throughput

0.541

High

274043

MED30
Mediator of RNA polymerase II transcription subunit 30

1

1

High-throughput

0.541

High

274049

PCGF6
Polycomb group RING finger protein 6

1

5

High-throughput

0.541

High

274053

TAF9B
Transcription initiation factor TFIID subunit 9B

1

2

High-throughput

0.541

High

274055

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.541

High

274059

ELF5
ETS-related transcription factor Elf-5

1

20

High-throughput

0.541

High

273999

CUL3
Cullin-3

1

8

High-throughput

0.536

High

274014

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

1

High-throughput

0.536

High

274027

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.518

High

274056

AATF
Protein AATF

1

0

High-throughput

0.518

High

274007

Q5TAL4
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.515

High

274017

Q86V38
Atrophin 1

1

5

High-throughput

0.515

High

274008

ANR22
Ankyrin repeat domain-containing protein 22

1

3

High-throughput

0.494

High

273970

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.481

High

273988

ATN1
Atrophin-1

1

19

High-throughput

0.481

High

274000

DGCR6
Protein DGCR6

1

1

High-throughput

0.481

High

142748

NFIB
Nuclear factor 1 B-type

1

16

High-throughput

0.479

High

181481

TBXT
T-box transcription factor T

1

10

High-throughput

0.479

High

209922

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

273964

ACL6A
Actin-like protein 6A

1

20

High-throughput

0.479

High

273965

FOS
Protein c-Fos

1

15

High-throughput

0.479

High

273966

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

273967

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

273968

MYCN
N-myc proto-oncogene protein

1

16

High-throughput

0.479

High

273969

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

273971

EGR2
E3 SUMO-protein ligase EGR2

1

20

High-throughput

0.479

High

273972

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

273974

ETS1
Protein C-ets-1

1

20

High-throughput

0.479

High

273975

MYOD1
Myoblast determination protein 1

1

9

High-throughput

0.479

High

273978

PAX7
Paired box protein Pax-7

1

18

High-throughput

0.479

High

273979

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

273981

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.479

High

273984

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

273987

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

273990

ACTC
Actin, alpha cardiac muscle 1

1

13

High-throughput

0.479

High

273993

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

273995

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

273996

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

274001

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

274009

ARID2
AT-rich interactive domain-containing protein 2

1

18

High-throughput

0.479

High

274013

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

20

High-throughput

0.479

High

274016

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

274019

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

274025

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

274026

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

274031

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

274038

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

274039

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

20

High-throughput

0.479

High

274046

FEV
Protein FEV

1

19

High-throughput

0.479

High

274047

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

15

High-throughput

0.479

High

274050

NSD3
Histone-lysine N-methyltransferase NSD3

1

10

Small-scale

0.479

High

274051

TRI31
E3 ubiquitin-protein ligase TRIM31

1

4

High-throughput

0.479

High

274052

BRD9
Bromodomain-containing protein 9

1

20

High-throughput

0.479

High

274054

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

274057

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

20

High-throughput

0.479

High

274058

LHX3
LIM/homeobox protein Lhx3

1

13

High-throughput

0.479

High

274011

Q6NVH9
Galectin

1

3

High-throughput

0.470

High

274029

JPH3
Junctophilin-3

1

2

High-throughput

0.470

High

274045

MIA2
Melanoma inhibitory activity protein 2

1

6

High-throughput

0.470

High

274032

TFG
Protein TFG

1

8

High-throughput

0.457

High

274020

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

5

High-throughput

0.437

High

3370

A0A0S2Z4Q4
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.417

High

274060

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

274030

F168A
Protein FAM168A

2

0

High-throughput

0.334

High

274006

CEP55
Centrosomal protein of 55 kDa

2

0

High-throughput

0.316

High

274012

CA094
Uncharacterized protein C1orf94

2

0

High-throughput

0.316

High

274041

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025