HitPredict

Interactor 1: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 35640677, 34273398, 25517749
Identification Methods enzymatic study, proximity labelling technology, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Gly_rich~Gly_rich, MAM~MAM, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0006950 - response to stress
and 23 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1620
Hs

1 1620
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Service provided by Combinatics, Japan

Last updated: 11Aug2025