HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29881947
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 822
+	Hs
		412212 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		NTRK2_HUMAN (1-822): 0: 638: 100.00
+	Hs
		146579 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		147391 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384184 SRC_HUMAN (1-176): 2.1e-43: 153: 15.76		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		412008 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		433229 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		412036 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		146597 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		434125 SRC_HUMAN (1-176): 2.1e-43: 153: 15.76		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Mm
		403421 SRC_MOUSE (1-176): 2.21e-43: 153: 15.76		RET_MOUSE (493-820): 7.8e-113: 371: 35.88
+	Hs
		146583 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		412153 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		146667 SOCS7_HUMAN (31-196): 1.96e-49: 170: 32.18		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		433332 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		147378 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		147373 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		435518 SRC_HUMAN (1-176): 2.1e-43: 153: 15.76		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Mm
		193373 SOCS3_MOUSE (25-194): 2.64e-47: 156: 29.15		INSR_MOUSE (513-809): 4.52e-68: 248: 42.72
+	Mm
		403410 SRC_MOUSE (1-176): 2.21e-43: 153: 15.76		INSR_MOUSE (513-809): 4.52e-68: 248: 42.72
+	Hs
		256861 SOCS5_HUMAN (11-197): 2.72e-43: 153: 30.16		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44