HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: CACL1 (Q86Y37)
CDK2-associated and cullin domain-containing protein 1 (Cdk-associated cullin 1)
Gene: CACUL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.595

Property	Details
Experiments	28883622
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 369
+	Hs
		146625 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		CUL4A_HUMAN (76-353): 3.18e-78: 257: 16.03
+	Hs
		147421 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		CUL4B_HUMAN (59-353): 1.42e-83: 273: 15.18
+	Hs
		337468 ABL1_HUMAN (3-173): 4.38e-42: 152: 19.65		CUL4B_HUMAN (59-353): 1.42e-83: 273: 15.18
+	Hs
		337467 ABL1_HUMAN (3-173): 4.38e-42: 152: 19.65		CUL4A_HUMAN (76-353): 3.18e-78: 257: 16.03
+	Hs
		789064 ABL2_HUMAN (3-173): 3.14e-42: 152: 18.50		CUL4A_HUMAN (76-353): 3.18e-78: 257: 16.03
+	Hs
		411713 LCK_HUMAN (1-172): 3.23e-43: 152: 15.63		CUL3_HUMAN (106-355): 1.94e-74: 247: 18.36
+	Hs
		146642 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		CUL5_HUMAN (133-355): 3.16e-50: 181: 8.44
+	Mm
		193366 SOCS2_MOUSE (1-198): 3.15e-63: 196: 93.94		CUL5_MOUSE (133-355): 2.53e-51: 184: 8.86
+	Mm
		1257617 SOCS7_MOUSE (31-196): 2.38e-49: 170: 32.18		CUL5_MOUSE (133-355): 2.53e-51: 184: 8.86
+	Hs
		146692 SOCS7_HUMAN (31-196): 1.96e-49: 170: 32.18		CUL5_HUMAN (133-355): 3.16e-50: 181: 8.44
+	Mm
		1143676 CISH_MOUSE (3-198): 1.55e-47: 157: 37.56		CUL5_MOUSE (133-355): 2.53e-51: 184: 8.86
+	Hs
		1041477 CISH_HUMAN (3-198): 4.83e-44: 149: 38.29		CUL2_HUMAN (123-353): 5.5e-54: 191: 9.41
+	Mm
		193394 SOCS3_MOUSE (25-194): 2.64e-47: 156: 29.15		CUL5_MOUSE (133-355): 2.53e-51: 184: 8.86
+	Hs
		147440 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		CUL5_HUMAN (133-355): 3.16e-50: 181: 8.44
+	Mm
		222648 SOCS5_MOUSE (11-197): 1.09e-42: 151: 29.63		CUL5_MOUSE (133-355): 2.53e-51: 184: 8.86
+	Hs
		256856 SOCS5_HUMAN (11-197): 2.72e-43: 153: 30.16		CUL5_HUMAN (133-355): 3.16e-50: 181: 8.44
+	Mm
		1265273 SOCS4_MOUSE (13-197): 8.66e-42: 147: 27.81		CUL5_MOUSE (133-355): 2.53e-51: 184: 8.86
+	Hs
		1274062 CISH_HUMAN (3-198): 4.83e-44: 149: 38.29		CUL5_HUMAN (133-355): 3.16e-50: 181: 8.44
+	Mm
		1322060 SOCS6_MOUSE (2-196): 1.63e-40: 145: 31.03		CUL5_MOUSE (133-355): 2.53e-51: 184: 8.86
+	Hs
		147544 SOCS6_HUMAN (2-196): 4.82e-41: 147: 31.03		CUL5_HUMAN (133-355): 3.16e-50: 181: 8.44