HitPredict

Interactor 1: MED17 (Q9VEC1)
Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) (dMED17) (dTRAP80)
Gene: MED17

Interactor 2: CDK8 (Q9VT57)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (DmCdk8) (Mediator complex subunit Cdk8) (Mediator of RNA polymerase II transcription subunit Cdk8)
Gene: CDK8

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016592 - mediator complex GO:0045498 - sex comb development
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 642 Dm			1 454
+	Hs
		881614 MED17_HUMAN (4-638): 0: 851: 42.49		CDK8_HUMAN (1-453): 6.39e-142: 415: 72.25
+	Hs
		1416405 MED17_HUMAN (4-638): 0: 851: 42.49		CDK19_HUMAN (1-442): 1.74e-138: 408: 72.85
+	Hs
		76441 MED17_HUMAN (4-638): 0: 851: 42.49		B4DUB1_HUMAN (152-369): 7.9e-134: 392: 84.86
+	Hs
		897405 MED17_HUMAN (4-638): 0: 851: 42.49		CDK7_HUMAN (5-381): 1.36e-111: 334: 32.03