Protein: CDK8
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)

Gene: CDK8
Organism: Homo sapiens
Interactions: 232
UniProt ID: P49336

Gene Ontology (top 5):
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666811

CCNC
Cyclin-C

27

20

Small-scale

0.993

High

239549

MED14
Mediator of RNA polymerase II transcription subunit 14

16

17

Small-scale

0.986

High

881620

MED13
Mediator of RNA polymerase II transcription subunit 13

17

7

Small-scale

0.985

High

287771

MED6
Mediator of RNA polymerase II transcription subunit 6

16

4

Small-scale

0.985

High

881552

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

9

7

High-throughput

0.974

High

881487

CDK8
Cyclin-dependent kinase 8

5

17

Small-scale

0.918

High

881600

CDK19
Cyclin-dependent kinase 19

5

18

Small-scale

0.915

High

171202

MYPT1
Protein phosphatase 1 regulatory subunit 12A

3

9

High-throughput

0.861

High

881508

CDK16
Cyclin-dependent kinase 16

3

19

High-throughput

0.861

High

881579

MED12
Mediator of RNA polymerase II transcription subunit 12

21

13

Small-scale

0.765

High

881530

MED1
Mediator of RNA polymerase II transcription subunit 1

17

11

Small-scale

0.765

High

282364

MED24
Mediator of RNA polymerase II transcription subunit 24

15

3

Small-scale

0.762

High

881518

MED21
Mediator of RNA polymerase II transcription subunit 21

15

3

Small-scale

0.762

High

881589

MED15
Mediator of RNA polymerase II transcription subunit 15

14

14

Small-scale

0.762

High

881614

MED17
Mediator of RNA polymerase II transcription subunit 17

15

4

Small-scale

0.762

High

881625

MED23
Mediator of RNA polymerase II transcription subunit 23

15

3

Small-scale

0.762

High

881615

MED9
Mediator of RNA polymerase II transcription subunit 9

13

2

Small-scale

0.761

High

881595

MED10
Mediator of RNA polymerase II transcription subunit 10

13

4

Small-scale

0.761

High

881630

MED16
Mediator of RNA polymerase II transcription subunit 16

13

3

Small-scale

0.761

High

881611

MED4
Mediator of RNA polymerase II transcription subunit 4

12

3

High-throughput

0.760

High

881616

MED29
Mediator of RNA polymerase II transcription subunit 29

11

3

High-throughput

0.759

High

48923

MED19
Mediator of RNA polymerase II transcription subunit 19

11

3

Small-scale

0.758

High

881533

CDC37
Hsp90 co-chaperone Cdc37

3

10

High-throughput

0.758

High

881608

MED20
Mediator of RNA polymerase II transcription subunit 20

11

3

Small-scale

0.758

High

881605

MED28
Mediator of RNA polymerase II transcription subunit 28

10

2

High-throughput

0.756

High

219478

MED7
Mediator of RNA polymerase II transcription subunit 7

10

5

Small-scale

0.755

High

881547

MED27
Mediator of RNA polymerase II transcription subunit 27

9

3

High-throughput

0.754

High

881584

MED8
Mediator of RNA polymerase II transcription subunit 8

9

3

High-throughput

0.754

High

241065

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.754

High

881492

CDK9
Cyclin-dependent kinase 9

2

19

Small-scale

0.754

High

881585

MED30
Mediator of RNA polymerase II transcription subunit 30

9

3

Small-scale

0.753

High

881632

MED31
Mediator of RNA polymerase II transcription subunit 31

8

5

Small-scale

0.752

High

881529

MED22
Mediator of RNA polymerase II transcription subunit 22

9

3

Small-scale

0.752

High

881553

MED25
Mediator of RNA polymerase II transcription subunit 25

10

3

Small-scale

0.751

High

881596

MED18
Mediator of RNA polymerase II transcription subunit 18

7

3

High-throughput

0.750

High

881617

MED11
Mediator of RNA polymerase II transcription subunit 11

6

2

High-throughput

0.734

High

881558

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

6

16

High-throughput

0.730

High

667208

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

11

Small-scale

0.727

High

335967

MED26
Mediator of RNA polymerase II transcription subunit 26

5

1

Small-scale

0.716

High

95743

E5RFK5
Cyclin-C

2

20

High-throughput

0.712

High

881536

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

170010

AURKA
Aurora kinase A

1

11

High-throughput

0.698

High

224095

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

16

High-throughput

0.698

High

410712

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

14

High-throughput

0.698

High

664678

CCND1
G1/S-specific cyclin-D1

1

20

High-throughput

0.698

High

787124

BMR1A
Bone morphogenetic protein receptor type-1A

1

6

High-throughput

0.698

High

881495

CCNH
Cyclin-H

1

20

Small-scale

0.692

High

472527

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

15

High-throughput

0.691

High

543095

UBL4A
Ubiquitin-like protein 4A

1

11

High-throughput

0.691

High

856585

BAG6
Large proline-rich protein BAG6

1

15

High-throughput

0.691

High

881499

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

16

High-throughput

0.691

High

881519

TRA2A
Transformer-2 protein homolog alpha

1

15

High-throughput

0.691

High

881559

RBM45
RNA-binding protein 45

1

14

High-throughput

0.691

High

881577

CELF1
CUGBP Elav-like family member 1

1

11

High-throughput

0.691

High

881598

RBM4
RNA-binding protein 4

1

17

High-throughput

0.691

High

881603

ZN350
Zinc finger protein 350

1

1

High-throughput

0.691

High

832673

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.647

High

251537

CCNT1
Cyclin-T1

1

20

Small-scale

0.646

High

375291

RASK
GTPase KRas

1

7

High-throughput

0.625

High

487079

PARP1
Poly [ADP-ribose] polymerase 1

2

9

Small-scale

0.624

High

881574

KAT2A
Histone acetyltransferase KAT2A

2

20

Small-scale

0.621

High

881636

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

2

3

Small-scale

0.619

High

881564

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

8

High-throughput

0.618

High

881622

DJC12
DnaJ homolog subfamily C member 12

1

4

High-throughput

0.618

High

187028

PPM1G
Protein phosphatase 1G

1

6

High-throughput

0.618

High

586248

ZEP1
Zinc finger protein 40

1

2

High-throughput

0.618

High

612935

EGR1
Early growth response protein 1

1

2

High-throughput

0.618

High

636051

CD11B
Cyclin-dependent kinase 11B

1

18

High-throughput

0.618

High

881490

CTCF
Transcriptional repressor CTCF

1

1

Small-scale

0.618

High

881496

MAT1
CDK-activating kinase assembly factor MAT1

1

3

High-throughput

0.618

High

881521

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

16

Small-scale

0.618

High

881525

MDC1
Mediator of DNA damage checkpoint protein 1

1

17

High-throughput

0.618

High

881528

STK38
Serine/threonine-protein kinase 38

1

12

Small-scale

0.618

High

881586

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

9

Small-scale

0.618

High

881599

NADAP
Kanadaptin

1

5

High-throughput

0.618

High

881609

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

8

High-throughput

0.618

High

881631

ZN281
Zinc finger protein 281

1

4

High-throughput

0.618

High

787848

SRBP1
Sterol regulatory element-binding protein 1

2

15

Small-scale

0.613

High

621590

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

1

High-throughput

0.611

High

881500

ZN131
Zinc finger protein 131

2

3

High-throughput

0.611

High

881582

MTBP
Mdm2-binding protein

3

1

Small-scale

0.599

High

881635

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

0

High-throughput

0.586

High

654624

TCEA1
Transcription elongation factor A protein 1

2

6

Small-scale

0.585

High

283445

TAD2A
Transcriptional adapter 2-alpha

2

4

High-throughput

0.584

High

770352

T2FA
General transcription factor IIF subunit 1

2

2

Small-scale

0.584

High

881514

TP53B
TP53-binding protein 1

2

9

High-throughput

0.584

High

881575

KAT2B
Histone acetyltransferase KAT2B

2

13

Small-scale

0.584

High

881532

SMAD1
Mothers against decapentaplegic homolog 1

1

10

Small-scale

0.578

High

76422

B4DUB1
cyclin-dependent kinase

1

17

High-throughput

0.575

High

162501

ANM5
Protein arginine N-methyltransferase 5

1

5

Small-scale

0.561

High

881592

MEP50
Methylosome protein WDR77

1

16

Small-scale

0.561

High

881633

TRRAP
Transformation/transcription domain-associated protein

1

4

Small-scale

0.554

High

659403

CRCM
Colorectal mutant cancer protein

1

13

High-throughput

0.541

High

873926

NRIP1
Nuclear receptor-interacting protein 1

1

0

Small-scale

0.537

High

178480

TBX3
T-box transcription factor TBX3

1

3

High-throughput

0.536

High

321830

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

3

High-throughput

0.536

High

342792

HERC2
E3 ubiquitin-protein ligase HERC2

1

11

High-throughput

0.536

High

601592

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.536

High

639683

TAF1
Transcription initiation factor TFIID subunit 1

1

19

High-throughput

0.536

High

775630

DEK
Protein DEK

1

1

High-throughput

0.536

High

853195

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.536

High

881512

TFCP2
Alpha-globin transcription factor CP2

1

3

High-throughput

0.536

High

881515

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.536

High

881534

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.536

High

881548

FXL19
F-box/LRR-repeat protein 19

1

7

High-throughput

0.536

High

881566

GEMI5
Gem-associated protein 5

1

14

High-throughput

0.536

High

881581

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

14

High-throughput

0.536

High

881593

BUD13
BUD13 homolog

1

6

High-throughput

0.536

High

881604

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

9

High-throughput

0.536

High

881491

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.527

High

174973

SC16A
Protein transport protein Sec16A

2

6

High-throughput

0.521

High

881619

MLH3
DNA mismatch repair protein Mlh3

1

0

High-throughput

0.518

High

384385

CRYAA
Alpha-crystallin A chain

1

2

High-throughput

0.515

High

881523

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.515

High

881576

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

319138

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.513

High

594835

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.513

High

881554

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.513

High

371457

MYC
Myc proto-oncogene protein

1

15

Small-scale

0.501

High

388051

MBP
Myelin basic protein

1

8

Small-scale

0.501

High

395688

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

413402

P53
Cellular tumor antigen p53

1

10

Small-scale

0.501

High

622777

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

7

Small-scale

0.501

High

881493

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

4

Small-scale

0.501

High

881507

SMAD3
Mothers against decapentaplegic homolog 3

1

10

Small-scale

0.501

High

881527

SUZ12
Polycomb protein SUZ12

1

1

Small-scale

0.501

High

881531

SMAD2
Mothers against decapentaplegic homolog 2

1

10

Small-scale

0.501

High

881551

H32
Histone H3.2

1

7

Small-scale

0.501

High

881570

MAML1
Mastermind-like protein 1

1

7

Small-scale

0.501

High

881572

ESR2
Estrogen receptor beta

1

20

Small-scale

0.501

High

259613

BRD4
Bromodomain-containing protein 4

1

18

Small-scale

0.500

High

881510

SRBP2
Sterol regulatory element-binding protein 2

1

15

Small-scale

0.500

High

555955

CADH1
Cadherin-1

1

3

High-throughput

0.494

High

881541

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.489

High

881557

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

1

4

High-throughput

0.489

High

881568

LZIC
Protein LZIC

1

2

High-throughput

0.489

High

139501

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

245075

AQR
RNA helicase aquarius

1

3

High-throughput

0.479

High

291912

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

9

High-throughput

0.479

High

331550

KIF4A
Chromosome-associated kinesin KIF4A

1

2

High-throughput

0.479

High

344893

WIZ
Protein Wiz

1

1

High-throughput

0.479

High

487985

DPOLA
DNA polymerase alpha catalytic subunit

1

6

High-throughput

0.479

High

519839

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

533257

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.479

High

606416

CEBPB
CCAAT/enhancer-binding protein beta

1

14

Small-scale

0.479

High

621835

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

708880

T2EA
General transcription factor IIE subunit 1

1

1

High-throughput

0.479

High

708932

T2EB
Transcription initiation factor IIE subunit beta

1

1

High-throughput

0.479

High

722909

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

5

High-throughput

0.479

High

787732

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

5

High-throughput

0.479

High

846564

MSH2
DNA mismatch repair protein Msh2

1

3

High-throughput

0.479

High

881488

PRI1
DNA primase small subunit

1

1

High-throughput

0.479

High

881494

HDGF
Hepatoma-derived growth factor

1

4

High-throughput

0.479

High

881497

IMA5
Importin subunit alpha-5

1

5

High-throughput

0.479

High

881498

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

881501

MFAP1
Microfibrillar-associated protein 1

1

3

High-throughput

0.479

High

881503

WDR5
WD repeat-containing protein 5

1

14

High-throughput

0.479

High

881505

TCPB
T-complex protein 1 subunit beta

1

20

Small-scale

0.479

High

881506

PRKDC
DNA-dependent protein kinase catalytic subunit

1

4

Small-scale

0.479

High

881509

E2F1
Transcription factor E2F1

1

14

Small-scale

0.479

High

881511

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.479

High

881513

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

Small-scale

0.479

High

881516

DDX10
Probable ATP-dependent RNA helicase DDX10

1

10

High-throughput

0.479

High

881517

PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

1

2

High-throughput

0.479

High

881520

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.479

High

881522

DPOA2
DNA polymerase alpha subunit B

1

1

High-throughput

0.479

High

881524

ELOA1
Elongin-A

1

7

High-throughput

0.479

High

881535

ARI4B
AT-rich interactive domain-containing protein 4B

1

8

High-throughput

0.479

High

881537

PCID2
PCI domain-containing protein 2

1

5

High-throughput

0.479

High

881538

RIF1
Telomere-associated protein RIF1

1

10

High-throughput

0.479

High

881539

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

18

High-throughput

0.479

High

881540

MYSM1
Deubiquitinase MYSM1

1

2

High-throughput

0.479

High

881543

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

2

High-throughput

0.479

High

881546

H3C
Histone H3.3C

1

7

High-throughput

0.479

High

881549

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

High-throughput

0.479

High

881550

ACD11
Acyl-CoA dehydrogenase family member 11

1

3

High-throughput

0.479

High

881555

TICRR
Treslin

1

12

Small-scale

0.479

High

881560

MGAP
MAX gene-associated protein

1

3

High-throughput

0.479

High

881561

SUGP2
SURP and G-patch domain-containing protein 2

1

3

High-throughput

0.479

High

881562

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

5

High-throughput

0.479

High

881565

PAF1
RNA polymerase II-associated factor 1 homolog

1

2

High-throughput

0.479

High

881567

PNISR
Arginine/serine-rich protein PNISR

1

6

High-throughput

0.479

High

881569

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

Small-scale

0.479

High

881573

CBP
CREB-binding protein

1

13

Small-scale

0.479

High

881578

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.479

High

881580

FBXW7
F-box/WD repeat-containing protein 7

1

14

Small-scale

0.479

High

881588

NACC1
Nucleus accumbens-associated protein 1

1

9

High-throughput

0.479

High

881591

SMAD5
Mothers against decapentaplegic homolog 5

1

10

Small-scale

0.479

High

881594

MTA3
Metastasis-associated protein MTA3

1

7

High-throughput

0.479

High

881601

FANCJ
Fanconi anemia group J protein

1

2

High-throughput

0.479

High

881602

SKI8
Superkiller complex protein 8

1

14

High-throughput

0.479

High

881606

ESF1
ESF1 homolog

1

1

High-throughput

0.479

High

881610

SYF1
Pre-mRNA-splicing factor SYF1

1

5

High-throughput

0.479

High

881613

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

881618

BCCIP
BRCA2 and CDKN1A-interacting protein

1

2

High-throughput

0.479

High

881621

XPO7
Exportin-7

1

2

High-throughput

0.479

High

881624

BRPF3
Bromodomain and PHD finger-containing protein 3

1

4

High-throughput

0.479

High

881626

YETS2
YEATS domain-containing protein 2

1

11

High-throughput

0.479

High

881629

TR150
Thyroid hormone receptor-associated protein 3

1

11

Small-scale

0.479

High

881634

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.479

High

881637

TF3C5
General transcription factor 3C polypeptide 5

1

1

High-throughput

0.479

High

881638

TF3C3
General transcription factor 3C polypeptide 3

1

5

High-throughput

0.479

High

881639

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

2

High-throughput

0.479

High

61728

SBNO1
Protein strawberry notch homolog 1

1

0

High-throughput

0.458

High

284810

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.458

High

881489

PRI2
DNA primase large subunit

1

0

High-throughput

0.458

High

881556

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

881563

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.458

High

881587

ZN830
Zinc finger protein 830

1

0

High-throughput

0.458

High

881597

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

881607

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.458

High

881612

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

881623

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.458

High

881627

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.458

High

96942

E9PGW7
Mediator of RNA polymerase II transcription subunit 22

1

3

High-throughput

0.445

High

516157

HS71A
Heat shock 70 kDa protein 1A

1

16

High-throughput

0.445

High

588179

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.445

High

798839

BRCA1
Breast cancer type 1 susceptibility protein

1

18

Small-scale

0.445

High

881502

SEC13
Protein SEC13 homolog

1

15

High-throughput

0.445

High

881504

H31
Histone H3.1

1

7

High-throughput

0.445

High

881526

SMC1A
Structural maintenance of chromosomes protein 1A

1

12

Small-scale

0.445

High

881544

NIPBL
Nipped-B-like protein

1

20

Small-scale

0.445

High

881583

RBM33
RNA-binding protein 33

1

10

High-throughput

0.445

High

881628

SMC3
Structural maintenance of chromosomes protein 3

1

12

Small-scale

0.445

High

881571

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.437

High

516792

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

881590

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

541886

TOP1
DNA topoisomerase 1

1

4

Small-scale

0.408

High

554787

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

881542

ZMYM4
Zinc finger MYM-type protein 4

1

0

High-throughput

0.249

Low

881545

RADX
RPA-related protein RADX

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025