Protein: MED17
Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)

Gene: MED17
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q9NVC6

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1414146

MED18
Mediator of RNA polymerase II transcription subunit 18

8

1

Small-scale

0.969

High

1149714

MED22
Mediator of RNA polymerase II transcription subunit 22

6

1

Small-scale

0.945

High

219521

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.932

High

1436779

MED20
Mediator of RNA polymerase II transcription subunit 20

5

1

High-throughput

0.927

High

1446520

MED4
Mediator of RNA polymerase II transcription subunit 4

5

1

High-throughput

0.927

High

1391340

MED8
Mediator of RNA polymerase II transcription subunit 8

5

1

High-throughput

0.925

High

1393382

MED30
Mediator of RNA polymerase II transcription subunit 30

5

1

Small-scale

0.925

High

239621

MED14
Mediator of RNA polymerase II transcription subunit 14

5

3

Small-scale

0.919

High

287822

MED6
Mediator of RNA polymerase II transcription subunit 6

5

1

Small-scale

0.919

High

1450384

MED11
Mediator of RNA polymerase II transcription subunit 11

4

1

High-throughput

0.900

High

1450398

MED31
Mediator of RNA polymerase II transcription subunit 31

3

1

High-throughput

0.871

High

192866

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.770

High

881614

CDK8
Cyclin-dependent kinase 8

15

4

Small-scale

0.762

High

1413633

MED10
Mediator of RNA polymerase II transcription subunit 10

12

1

Small-scale

0.760

High

49024

MED19
Mediator of RNA polymerase II transcription subunit 19

10

1

Small-scale

0.758

High

1151298

MED1
Mediator of RNA polymerase II transcription subunit 1

10

1

Small-scale

0.754

High

1450381

MED29
Mediator of RNA polymerase II transcription subunit 29

8

1

Small-scale

0.752

High

1431399

MED28
Mediator of RNA polymerase II transcription subunit 28

8

1

Small-scale

0.750

High

667476

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.748

High

1416405

CDK19
Cyclin-dependent kinase 19

8

4

Small-scale

0.748

High

1372204

MED12
Mediator of RNA polymerase II transcription subunit 12

6

2

High-throughput

0.732

High

1241416

MED27
Mediator of RNA polymerase II transcription subunit 27

5

1

Small-scale

0.718

High

336033

MED26
Mediator of RNA polymerase II transcription subunit 26

5

1

High-throughput

0.716

High

1450380

MED9
Mediator of RNA polymerase II transcription subunit 9

7

0

Small-scale

0.715

High

666918

CCNC
Cyclin-C

5

1

High-throughput

0.706

High

1450391

MED23
Mediator of RNA polymerase II transcription subunit 23

4

2

High-throughput

0.694

High

282423

MED24
Mediator of RNA polymerase II transcription subunit 24

4

1

High-throughput

0.691

High

1259072

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

4

2

High-throughput

0.691

High

1450396

MED16
Mediator of RNA polymerase II transcription subunit 16

4

1

High-throughput

0.691

High

1108406

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.690

High

1450388

MED13
Mediator of RNA polymerase II transcription subunit 13

4

2

High-throughput

0.687

High

1401570

MED15
Mediator of RNA polymerase II transcription subunit 15

4

1

Small-scale

0.683

High

976160

RPB7
DNA-directed RNA polymerase II subunit RPB7

5

0

High-throughput

0.682

High

1134813

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

5

High-throughput

0.667

High

1367396

ESR2
Estrogen receptor beta

3

5

Small-scale

0.660

High

1259285

MED25
Mediator of RNA polymerase II transcription subunit 25

3

1

Small-scale

0.650

High

260520

BRD4
Bromodomain-containing protein 4

3

1

Small-scale

0.640

High

1313059

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.628

High

912245

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.622

High

1295678

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

2

High-throughput

0.611

High

188722

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

621985

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

681938

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

712290

TKT
Transketolase

2

0

High-throughput

0.602

High

621765

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.585

High

723111

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

959069

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.585

High

397046

ESR1
Estrogen receptor

2

5

Small-scale

0.585

High

903497

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

1

Small-scale

0.585

High

1369168

KAT2A
Histone acetyltransferase KAT2A

2

2

Small-scale

0.571

High

787899

SRBP1
Sterol regulatory element-binding protein 1

2

0

Small-scale

0.569

High

1380196

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

533307

THA
Thyroid hormone receptor alpha

2

4

Small-scale

0.552

High

799510

BRCA1
Breast cancer type 1 susceptibility protein

2

1

Small-scale

0.552

High

1450386

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.537

High

270851

ROCK2
Rho-associated protein kinase 2

1

1

High-throughput

0.536

High

654683

TCEA1
Transcription elongation factor A protein 1

1

1

High-throughput

0.536

High

853420

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.536

High

1194409

LARP7
La-related protein 7

1

1

High-throughput

0.536

High

1270340

SPT6H
Transcription elongation factor SPT6

1

1

High-throughput

0.536

High

1434914

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

2

High-throughput

0.536

High

1450385

STK26
Serine/threonine-protein kinase 26

1

1

High-throughput

0.536

High

1450402

STK24
Serine/threonine-protein kinase 24

1

1

High-throughput

0.536

High

1227554

A16L1
Autophagy-related protein 16-1

2

2

High-throughput

0.521

High

61762

SBNO1
Protein strawberry notch homolog 1

1

0

High-throughput

0.513

High

130627

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.513

High

171337

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

High-throughput

0.513

High

220028

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

225338

HTSF1
17S U2 SnRNP complex component HTATSF1

1

0

High-throughput

0.513

High

286501

WBP4
WW domain-binding protein 4

1

0

High-throughput

0.513

High

337398

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.513

High

370790

FOS
Protein c-Fos

1

0

High-throughput

0.513

High

384563

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.513

High

590502

GATA1
Erythroid transcription factor

1

0

Small-scale

0.513

High

708917

T2EA
General transcription factor IIE subunit 1

1

0

High-throughput

0.513

High

1051971

KPCD
Protein kinase C delta type

1

0

High-throughput

0.513

High

1104938

XRCC4
DNA repair protein XRCC4

1

0

High-throughput

0.513

High

1107627

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.513

High

1133364

NC2A
Dr1-associated corepressor

1

0

High-throughput

0.513

High

1150896

CIP4
Cdc42-interacting protein 4

1

0

High-throughput

0.513

High

1153745

TOM34
Mitochondrial import receptor subunit TOM34

1

0

High-throughput

0.513

High

1228337

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.513

High

1243781

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1323577

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.513

High

1329578

CA052
UPF0690 protein C1orf52

1

0

High-throughput

0.513

High

1339564

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.513

High

1358779

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.513

High

1370633

GPKOW
G-patch domain and KOW motifs-containing protein

1

0

High-throughput

0.513

High

1383988

ARK2N
Protein ARK2N

1

0

High-throughput

0.513

High

1387375

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

1400396

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

1408482

VRK1
Serine/threonine-protein kinase VRK1

1

0

High-throughput

0.513

High

1420953

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.513

High

1446195

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.513

High

1450382

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.513

High

1450393

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.513

High

1450395

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

1450397

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

1450400

PPME1
Protein phosphatase methylesterase 1

1

0

High-throughput

0.513

High

887262

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

834070

HNF4A
Hepatocyte nuclear factor 4-alpha

1

5

Small-scale

0.501

High

1106308

ROCK1
Rho-associated protein kinase 1

1

1

High-throughput

0.489

High

1131240

MESD
LRP chaperone MESD

1

1

High-throughput

0.489

High

1431835

SLK
STE20-like serine/threonine-protein kinase

1

3

High-throughput

0.489

High

1450389

GPN3
GPN-loop GTPase 3

1

1

High-throughput

0.489

High

414713

P53
Cellular tumor antigen p53

1

0

Small-scale

0.480

High

832815

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.480

High

1137543

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.480

High

1450401

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

143290

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

283558

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

316064

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

316324

RECQ5
ATP-dependent DNA helicase Q5

1

1

High-throughput

0.479

High

326384

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.479

High

373280

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

404471

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

474327

NFIC
Nuclear factor 1 C-type

1

5

High-throughput

0.479

High

520406

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

787797

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

1088053

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

1133694

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

1153931

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

1154013

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

1212046

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

1

High-throughput

0.479

High

1439333

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.479

High

1417006

HEMGN
Hemogen

1

0

Small-scale

0.460

High

243083

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

262573

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

283628

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

319178

ST65G
STAGA complex 65 subunit gamma

1

0

Small-scale

0.458

High

343074

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

487806

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

552885

TPR
Nucleoprotein TPR

1

0

High-throughput

0.458

High

589830

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

643094

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

862494

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

897405

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

905190

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

912136

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

920305

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

923549

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

980416

H4
Histone H4

1

0

High-throughput

0.458

High

983716

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1029954

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1089034

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1120363

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

1151394

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1217622

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1257828

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1258321

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

1329898

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1336859

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1397478

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1400079

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1407425

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1434832

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1450383

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1450387

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1450390

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1450392

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.458

High

95760

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1207512

Q5JWT2
Mediator of RNA polymerase II transcription subunit 23

1

2

High-throughput

0.445

High

1336638

PAPD5
Terminal nucleotidyltransferase 4B

1

1

High-throughput

0.437

High

253989

LPXN
Leupaxin

1

0

High-throughput

0.426

High

1401883

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1406783

BARD1
BRCA1-associated RING domain protein 1

1

0

Small-scale

0.426

High

1450399

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.426

High

76441

B4DUB1
cyclin-dependent kinase

1

4

High-throughput

0.407

High

109163

G4U4J3
Terminal nucleotidyltransferase 4B

1

2

High-throughput

0.407

High

352645

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

294406

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.279

Low

295364

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.279

Low

423854

APOD
Apolipoprotein D

1

0

High-throughput

0.279

Low

479478

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.279

Low

999418

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.279

Low

1027205

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.279

Low

1135475

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

0

High-throughput

0.279

Low

1136388

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

1324923

RHG18
Rho GTPase-activating protein 18

1

0

High-throughput

0.279

Low

1348975

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1388427

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.279

Low

1395610

BT3L4
Transcription factor BTF3 homolog 4

1

0

High-throughput

0.279

Low

1398541

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.279

Low

1410217

CMS1
Protein CMSS1

1

0

High-throughput

0.279

Low

1430311

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.279

Low

1433640

E41L1
Band 4.1-like protein 1

1

0

High-throughput

0.279

Low

1450394

RT33
Small ribosomal subunit protein mS33

1

0

High-throughput

0.279

Low

387566

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

412687

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1232027

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1255765

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

2135

PAL4C
Peptidyl-prolyl cis-trans isomerase A-like 4C

1

0

High-throughput

0.232

Low

506035

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

1212243

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025