HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	12560330, 15514089
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1382
+	Hs
		146667 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Mm
		193373 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		INSR_MOUSE (1-1382): 0: 1509: 94.36
+	Hs
		147378 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Mm
		763386 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		EPHA4_MOUSE (562-1354): 0: 568: 20.48
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21
+	Hs
		412036 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		EPHA3_HUMAN (570-1319): 7.94e-174: 545: 20.56
+	Hs
		147371 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		383538 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		383551 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		256843 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		383529 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		383547 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		256861 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53
+	Hs
		147391 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78
+	Hs
		147395 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09
+	Hs
		147390 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		433253 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		454797 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		256849 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		442779 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11