Protein: IRF3
Interferon regulatory factor 3 (IRF-3)

Gene: IRF3
Organism: Homo sapiens
Interactions: 169
UniProt ID: Q14653

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 - DNA-binding transcription activator activity
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1129137

IRF3
Interferon regulatory factor 3

52

17

Small-scale

0.996

High

1129165

CBP
CREB-binding protein

28

17

Small-scale

0.993

High

1067328

EP300
Histone acetyltransferase p300

11

17

Small-scale

0.978

High

1129169

IRF7
Interferon regulatory factor 7

5

17

Small-scale

0.924

High

1129195

TBK1
Serine/threonine-protein kinase TBK1

34

14

Small-scale

0.769

High

1110867

IRF5
Interferon regulatory factor 5

2

16

Small-scale

0.768

High

378377

IFNB
Interferon beta

13

20

Small-scale

0.756

High

1122481

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

10

14

Small-scale

0.751

High

425502

ISG15
Ubiquitin-like protein ISG15

10

10

Small-scale

0.748

High

1129155

MAVS
Mitochondrial antiviral-signaling protein

6

3

Small-scale

0.739

High

1129156

STING
Stimulator of interferon genes protein

7

2

Small-scale

0.739

High

378237

IFNA1
Interferon alpha-1/13

5

20

Small-scale

0.709

High

461481

HS90A
Heat shock protein HSP 90-alpha

3

7

Small-scale

0.685

High

623346

RO52
E3 ubiquitin-protein ligase TRIM21

3

9

Small-scale

0.678

High

1129158

TCAM1
TIR domain-containing adapter molecule 1

4

2

Small-scale

0.676

High

345072

RIGI
Antiviral innate immune response receptor RIG-I

3

7

Small-scale

0.650

High

533934

IRF1
Interferon regulatory factor 1

1

16

Small-scale

0.646

High

488177

IFIT1
Antiviral innate immune response effector IFIT1

3

8

Small-scale

0.640

High

562894

CCL5
C-C motif chemokine 5

3

10

Small-scale

0.640

High

1095630

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

3

4

Small-scale

0.640

High

1107715

SQSTM
Sequestosome-1

3

3

Small-scale

0.640

High

1129166

TANK
TRAF family member-associated NF-kappa-B activator

3

2

Small-scale

0.640

High

322943

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

2

2

High-throughput

0.628

High

1129170

GLMN
Glomulin

2

0

High-throughput

0.602

High

1129176

MOCOS
Molybdenum cofactor sulfurase

2

0

High-throughput

0.602

High

1129197

MSRA
Mitochondrial peptide methionine sulfoxide reductase

2

0

High-throughput

0.602

High

910897

IMA1
Importin subunit alpha-1

2

5

Small-scale

0.601

High

442715

RB
Retinoblastoma-associated protein

1

2

High-throughput

0.586

High

704966

RBL1
Retinoblastoma-like protein 1

1

2

High-throughput

0.586

High

853680

MK08
Mitogen-activated protein kinase 8

1

1

Small-scale

0.586

High

1109261

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

Small-scale

0.585

High

172814

XPO1
Exportin-1

2

3

Small-scale

0.584

High

193273

SOCS1
Suppressor of cytokine signaling 1

2

8

Small-scale

0.584

High

241686

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

378252

IFNA2
Interferon alpha-2

2

20

Small-scale

0.584

High

378333

IFN14
Interferon alpha-14

2

20

Small-scale

0.584

High

712731

IL12A
Interleukin-12 subunit alpha

2

7

Small-scale

0.584

High

1085549

FOXO1
Forkhead box protein O1

2

6

Small-scale

0.584

High

1094896

TRAF3
TNF receptor-associated factor 3

2

20

Small-scale

0.584

High

1117270

APR
Phorbol-12-myristate-13-acetate-induced protein 1

2

1

Small-scale

0.584

High

1089201

TRI26
Tripartite motif-containing protein 26

1

11

Small-scale

0.578

High

1129196

HERC5
E3 ISG15--protein ligase HERC5

1

5

Small-scale

0.578

High

226772

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

6

High-throughput

0.573

High

994219

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

0

Small-scale

0.569

High

138110

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

Small-scale

0.561

High

318010

TOM70
Mitochondrial import receptor subunit TOM70

1

2

Small-scale

0.561

High

1129150

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

Small-scale

0.561

High

913880

ZN143
Zinc finger protein 143

2

0

Small-scale

0.559

High

1032962

EWS
RNA-binding protein EWS

1

2

High-throughput

0.541

High

334008

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.536

High

335684

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

2

High-throughput

0.536

High

532082

KIT
Mast/stem cell growth factor receptor Kit

1

1

High-throughput

0.536

High

700633

PSA5
Proteasome subunit alpha type-5

1

1

High-throughput

0.536

High

720224

UFO
Tyrosine-protein kinase receptor UFO

1

2

High-throughput

0.536

High

853794

MK09
Mitogen-activated protein kinase 9

1

1

Small-scale

0.536

High

881182

FAS
Fatty acid synthase

1

1

High-throughput

0.536

High

914080

HXK2
Hexokinase-2

1

3

High-throughput

0.536

High

1065661

RBL2
Retinoblastoma-like protein 2

1

2

High-throughput

0.536

High

1123625

DCTN1
Dynactin subunit 1

1

2

High-throughput

0.536

High

1129138

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.536

High

1129139

SLMAP
Sarcolemmal membrane-associated protein

1

3

High-throughput

0.536

High

1129142

GRDN
Girdin

1

4

High-throughput

0.536

High

1129179

WRIP1
ATPase WRNIP1

1

1

High-throughput

0.536

High

1129201

SALL2
Sal-like protein 2

1

1

High-throughput

0.536

High

1129205

KC1G3
Casein kinase I isoform gamma-3

1

2

High-throughput

0.536

High

253629

IMA7
Importin subunit alpha-7

1

5

Small-scale

0.534

High

1129161

PIAS4
E3 SUMO-protein ligase PIAS4

1

3

Small-scale

0.534

High

1129204

MAFB
Transcription factor MafB

1

3

Small-scale

0.534

High

518784

IL8
Interleukin-8

2

10

Small-scale

0.533

High

1129146

OTUD1
OTU domain-containing protein 1

2

4

Small-scale

0.533

High

1060085

BAX
Apoptosis regulator BAX

1

1

Small-scale

0.527

High

828363

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.518

High

728238

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.515

High

1106535

SMAD4
Mothers against decapentaplegic homolog 4

1

4

Small-scale

0.515

High

1129140

SMAD2
Mothers against decapentaplegic homolog 2

1

4

Small-scale

0.515

High

48623

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.513

High

161813

RIOK3
Serine/threonine-protein kinase RIO3

1

0

Small-scale

0.513

High

341247

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

1

0

High-throughput

0.513

High

1086528

TROP
Trophinin

1

0

High-throughput

0.513

High

1129141

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

1129181

SORT
Sortilin

1

0

High-throughput

0.513

High

1129191

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.513

High

1129194

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.513

High

1129203

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.513

High

1129200

GRIP1
Glutamate receptor-interacting protein 1

1

2

Small-scale

0.506

High

185698

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

299194

FLOT1
Flotillin-1

1

6

High-throughput

0.500

High

1124802

FLOT2
Flotillin-2

1

6

High-throughput

0.500

High

1129180

PSB7
Proteasome subunit beta type-7

1

9

High-throughput

0.500

High

338616

AGRL2
Adhesion G protein-coupled receptor L2

1

1

High-throughput

0.489

High

1129172

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.489

High

1057151

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.481

High

1129171

TRI63
E3 ubiquitin-protein ligase TRIM63

1

16

High-throughput

0.481

High

1129188

TRI55
Tripartite motif-containing protein 55

1

17

High-throughput

0.481

High

1129199

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

186547

TRI18
E3 ubiquitin-protein ligase Midline-1

1

15

Small-scale

0.479

High

188277

HDAC3
Histone deacetylase 3

1

5

Small-scale

0.479

High

225415

CIKS
E3 ubiquitin ligase TRAF3IP2

1

1

Small-scale

0.479

High

252350

TLR2
Toll-like receptor 2

1

13

Small-scale

0.479

High

279163

ULK1
Serine/threonine-protein kinase ULK1

1

2

Small-scale

0.479

High

280419

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

3

Small-scale

0.479

High

378092

TNFA
Tumor necrosis factor

1

7

Small-scale

0.479

High

378271

IFNA7
Interferon alpha-7

1

20

Small-scale

0.479

High

390397

CXL10
C-X-C motif chemokine 10

1

10

Small-scale

0.479

High

468375

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.479

High

488121

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

8

Small-scale

0.479

High

507192

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

3

Small-scale

0.479

High

576229

PO2F1
POU domain, class 2, transcription factor 1

1

4

Small-scale

0.479

High

633376

MX1
Interferon-induced GTP-binding protein Mx1

1

1

Small-scale

0.479

High

647556

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.479

High

651329

CBL
E3 ubiquitin-protein ligase CBL

1

13

Small-scale

0.479

High

656125

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

Small-scale

0.479

High

714119

PML
Protein PML

1

14

Small-scale

0.479

High

777279

AHR
Aryl hydrocarbon receptor

1

1

Small-scale

0.479

High

862133

YAP1
Transcriptional coactivator YAP1

1

2

Small-scale

0.479

High

897143

TNF10
Tumor necrosis factor ligand superfamily member 10

1

7

Small-scale

0.479

High

946658

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

Small-scale

0.479

High

970500

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

1022714

XIAP
E3 ubiquitin-protein ligase XIAP

1

3

Small-scale

0.479

High

1025097

TF2B
Transcription initiation factor IIB

1

2

Small-scale

0.479

High

1050420

UBE3A
Ubiquitin-protein ligase E3A

1

6

Small-scale

0.479

High

1090644

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1112486

CUL1
Cullin-1

1

2

Small-scale

0.479

High

1125432

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

Small-scale

0.479

High

1129143

TBB8
Tubulin beta-8 chain

1

2

High-throughput

0.479

High

1129145

ZC12A
Endoribonuclease ZC3H12A

1

2

Small-scale

0.479

High

1129149

OTU7B
OTU domain-containing protein 7B

1

3

Small-scale

0.479

High

1129152

WDR82
WD repeat-containing protein 82

1

1

Small-scale

0.479

High

1129153

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

1129154

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

1129157

IFNL1
Interferon lambda-1

1

7

Small-scale

0.479

High

1129160

IFNL3
Interferon lambda-3

1

7

Small-scale

0.479

High

1129163

IL27A
Interleukin-27 subunit alpha

1

3

Small-scale

0.479

High

1129164

HDAC2
Histone deacetylase 2

1

5

Small-scale

0.479

High

1129168

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

1

Small-scale

0.479

High

1129175

FBX17
F-box only protein 17

1

1

Small-scale

0.479

High

1129182

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

1

Small-scale

0.479

High

1129183

CCL19
C-C motif chemokine 19

1

10

Small-scale

0.479

High

1129184

MYD88
Myeloid differentiation primary response protein MyD88

1

20

Small-scale

0.479

High

1129185

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

1129186

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

Small-scale

0.479

High

1129187

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

Small-scale

0.479

High

1129189

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

11

Small-scale

0.479

High

1129192

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

4

Small-scale

0.479

High

1129193

FBX6
F-box only protein 6

1

1

Small-scale

0.479

High

1129202

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

319764

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

134032

IPO5
Importin-5

1

0

Small-scale

0.458

High

141486

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

336959

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

High-throughput

0.458

High

875857

GSHB
Glutathione synthetase

1

0

Small-scale

0.458

High

1128718

NBR1
Next to BRCA1 gene 1 protein

1

0

Small-scale

0.458

High

1129151

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

Small-scale

0.458

High

1129174

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1129190

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

Small-scale

0.458

High

1129162

OTU6B
Deubiquitinase OTUD6B

1

3

Small-scale

0.437

High

1129173

Q96BE0
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

1129159

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.426

High

1129148

ANR40
Ankyrin repeat domain-containing protein 40

2

0

High-throughput

0.328

High

1129177

CE034
Uncharacterized protein C5orf34

2

0

High-throughput

0.328

High

226483

SNG3
Synaptogyrin-3

1

0

High-throughput

0.279

Low

565617

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.279

Low

1129178

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

890734

PSN2
Presenilin-2

1

0

High-throughput

0.269

Low

1129144

Q53FC7
Heat shock 70 kDa protein 6

1

0

High-throughput

0.249

Low

1129147

TEX36
Testis-expressed protein 36

1

0

High-throughput

0.249

Low

1129167

MRP2
ATP-binding cassette sub-family C member 2

1

0

Small-scale

0.249

Low

1129198

TMED7
Transmembrane emp24 domain-containing protein 7

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025