HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 245
+	Hs
		411661 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		411605 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		411666 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		782766 CSK_HUMAN (3-220): 3.6e-38: 139: 12.45		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		147487 SOCS6_HUMAN (15-220): 4.58e-39: 143: 22.64		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		782768 CSK_HUMAN (3-220): 3.6e-38: 139: 12.45		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		683181 CSK_HUMAN (3-220): 3.6e-38: 139: 12.45		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Mm
		140059 P85B_MOUSE (37-161): 8.4e-19: 86.4: 21.60		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Hs
		129265 P85B_HUMAN (37-147): 1.75e-18: 85.6: 22.52		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		655301 P85A_HUMAN (35-153): 1.46e-17: 82.9: 18.49		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		129204 P85B_HUMAN (37-147): 1.75e-18: 85.6: 22.52		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		129271 P85B_HUMAN (37-147): 1.75e-18: 85.6: 22.52		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		655308 P85A_HUMAN (35-153): 1.46e-17: 82.9: 18.49		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		129216 P85B_HUMAN (37-147): 1.75e-18: 85.6: 22.52		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		411616 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		147513 SOCS6_HUMAN (15-220): 4.58e-39: 143: 22.64		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		147502 SOCS6_HUMAN (15-220): 4.58e-39: 143: 22.64		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		782764 CSK_HUMAN (3-220): 3.6e-38: 139: 12.45		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		655299 P85A_HUMAN (35-153): 1.46e-17: 82.9: 18.49		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33