Protein: CNR2
Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5)

Gene: CNR2
Organism: Homo sapiens
Interactions: 110
UniProt ID: P34972

Gene Ontology (top 5):
GO:0001975 - response to amphetamine
GO:0004949 - cannabinoid receptor activity
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

561027

CCL4
C-C motif chemokine 4

2

0

High-throughput

0.742

High

452181

PDIA1
Protein disulfide-isomerase

1

3

Small-scale

0.691

High

717377

PDIA3
Protein disulfide-isomerase A3

1

4

Small-scale

0.691

High

762154

TMX3
Protein disulfide-isomerase TMX3

1

4

Small-scale

0.691

High

762173

TBL2
Transducin beta-like protein 2

1

1

Small-scale

0.691

High

762163

TMX1
Thioredoxin-related transmembrane protein 1

1

6

Small-scale

0.618

High

762164

SEC12
Guanine nucleotide-exchange factor SEC12

1

3

Small-scale

0.618

High

762123

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.618

High

642203

COMT
Catechol O-methyltransferase

2

3

High-throughput

0.606

High

762136

TSPO2
Translocator protein 2

2

1

High-throughput

0.606

High

762152

YIPF6
Protein YIPF6

2

6

High-throughput

0.606

High

762159

YIPF4
Protein YIPF4

2

6

High-throughput

0.606

High

762165

S39A2
Zinc transporter ZIP2

2

20

High-throughput

0.606

High

762166

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

6

High-throughput

0.606

High

762174

YIPF1
Protein YIPF1

2

6

High-throughput

0.606

High

762127

FXYD3
FXYD domain-containing ion transport regulator 3

2

0

High-throughput

0.580

High

762131

ADIPO
Adiponectin

2

0

High-throughput

0.580

High

762146

MUC15
Mucin-15

2

0

High-throughput

0.580

High

762149

TM203
Transmembrane protein 203

2

0

High-throughput

0.580

High

762171

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

2

0

High-throughput

0.580

High

762175

SELK
Selenoprotein K

2

0

High-throughput

0.580

High

762137

S35E4
Solute carrier family 35 member E4

2

1

High-throughput

0.553

High

762138

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

1

High-throughput

0.553

High

762151

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

2

4

High-throughput

0.553

High

762153

TMM19
Transmembrane protein 19

2

1

High-throughput

0.553

High

762167

TM242
Transmembrane protein 242

2

1

High-throughput

0.553

High

130012

PGRC1
Membrane-associated progesterone receptor component 1

1

4

Small-scale

0.536

High

170679

CLGN
Calmegin

1

3

Small-scale

0.536

High

171405

S27A2
Long-chain fatty acid transport protein 2

1

2

Small-scale

0.536

High

172508

XPO1
Exportin-1

1

20

Small-scale

0.536

High

180488

PLS1
Phospholipid scramblase 1

1

3

Small-scale

0.536

High

181268

PGRC2
Membrane-associated progesterone receptor component 2

1

4

Small-scale

0.536

High

184130

RER1
Protein RER1

1

2

Small-scale

0.536

High

184808

SPTC1
Serine palmitoyltransferase 1

1

4

Small-scale

0.536

High

258782

DNJA2
DnaJ homolog subfamily A member 2

1

1

Small-scale

0.536

High

297161

PRAF3
PRA1 family protein 3

1

5

Small-scale

0.536

High

348387

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

Small-scale

0.536

High

417282

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

Small-scale

0.536

High

417971

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

Small-scale

0.536

High

424150

S10A8
Protein S100-A8

1

1

Small-scale

0.536

High

444918

S10A9
Protein S100-A9

1

1

Small-scale

0.536

High

520762

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

Small-scale

0.536

High

522603

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

2

Small-scale

0.536

High

568204

PLST
Plastin-3

1

3

Small-scale

0.536

High

598015

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

20

Small-scale

0.536

High

627271

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

20

Small-scale

0.536

High

665385

EF1B
Elongation factor 1-beta

1

2

Small-scale

0.536

High

698429

CALX
Calnexin

1

3

Small-scale

0.536

High

716497

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

1

Small-scale

0.536

High

762105

FDFT
Squalene synthase

1

3

Small-scale

0.536

High

762110

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

Small-scale

0.536

High

762113

SSRD
Translocon-associated protein subunit delta

1

1

Small-scale

0.536

High

762114

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

Small-scale

0.536

High

762115

COPB
Coatomer subunit beta

1

2

Small-scale

0.536

High

762116

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

Small-scale

0.536

High

762117

ARF3
ADP-ribosylation factor 3

1

2

Small-scale

0.536

High

762119

SELT
Thioredoxin reductase-like selenoprotein T

1

2

Small-scale

0.536

High

762120

S25A3
Solute carrier family 25 member 3

1

15

Small-scale

0.536

High

762121

KDSR
3-ketodihydrosphingosine reductase

1

14

Small-scale

0.536

High

762126

RCN2
Reticulocalbin-2

1

1

Small-scale

0.536

High

762128

S39AE
Metal cation symporter ZIP14

1

20

Small-scale

0.536

High

762129

TMED2
Transmembrane emp24 domain-containing protein 2

1

5

Small-scale

0.536

High

762130

DHC24
Delta(24)-sterol reductase

1

2

Small-scale

0.536

High

762133

MBRL
Membralin

1

4

Small-scale

0.536

High

762134

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

7

Small-scale

0.536

High

762139

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

Small-scale

0.536

High

762141

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

Small-scale

0.536

High

762148

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

4

Small-scale

0.536

High

762150

CCD47
PAT complex subunit CCDC47

1

1

Small-scale

0.536

High

762155

SEC62
Translocation protein SEC62

1

2

Small-scale

0.536

High

762156

SGMR1
Sigma non-opioid intracellular receptor 1

1

5

Small-scale

0.536

High

762157

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

3

Small-scale

0.536

High

762158

TBA1C
Tubulin alpha-1C chain

1

4

Small-scale

0.536

High

762160

TBB2B
Tubulin beta-2B chain

1

5

Small-scale

0.536

High

762168

HACD3
Very-long-chain

1

3

Small-scale

0.536

High

762170

GGT7
Glutathione hydrolase 7

1

1

Small-scale

0.536

High

762125

SQSTM
Sequestosome-1

1

0

Small-scale

0.520

High

332285

ATE1
Arginyl-tRNA--protein transferase 1

1

0

Small-scale

0.513

High

467387

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.513

High

762106

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

Small-scale

0.513

High

762111

GDIB
Rab GDP dissociation inhibitor beta

1

0

Small-scale

0.513

High

762112

EMD
Emerin

1

0

Small-scale

0.513

High

762169

SE1L1
Protein sel-1 homolog 1

1

0

Small-scale

0.513

High

50499

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

Small-scale

0.489

High

207798

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

2

Small-scale

0.489

High

219278

B4GA1
Beta-1,4-glucuronyltransferase 1

1

3

Small-scale

0.489

High

280137

SC22B
Vesicle-trafficking protein SEC22b

1

1

Small-scale

0.489

High

547556

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

2

Small-scale

0.489

High

559886

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

Small-scale

0.489

High

762109

EFTU
Elongation factor Tu, mitochondrial

1

2

Small-scale

0.489

High

762118

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

Small-scale

0.489

High

762122

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

Small-scale

0.489

High

762135

HECD3
E3 ubiquitin-protein ligase HECTD3

1

10

Small-scale

0.489

High

762140

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

3

Small-scale

0.489

High

762142

MIRO2
Mitochondrial Rho GTPase 2

1

5

Small-scale

0.489

High

762144

K2013
Uncharacterized protein KIAA2013

1

6

Small-scale

0.489

High

762147

COQ8A
Atypical kinase COQ8A, mitochondrial

1

2

Small-scale

0.489

High

762161

FACD2
Fanconi anemia group D2 protein

1

3

Small-scale

0.489

High

762172

DHRS7
Dehydrogenase/reductase SDR family member 7

1

13

Small-scale

0.489

High

63814

PEDS1
Plasmanylethanolamine desaturase 1

1

1

High-throughput

0.481

High

116726

I3L0A0
HCG2044781

1

1

High-throughput

0.470

High

762108

PI4KA
Phosphatidylinositol 4-kinase alpha

1

7

Small-scale

0.445

High

762124

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.437

High

762132

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

6

Small-scale

0.437

High

762143

NRM
Nurim

2

0

High-throughput

0.316

High

762145

TM86A
Lysoplasmalogenase TMEM86A

2

0

High-throughput

0.316

High

762162

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

360385

COX2
Cytochrome c oxidase subunit 2

1

0

Small-scale

0.279

Low

644470

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

0

Small-scale

0.279

Low

762107

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.279

Low


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Last updated: 11Aug2025