HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: ELOC (Q15369)
Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1)
Gene: ELOC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	22084247, 12783885, 30166453, 33961781, 17135358, 15601820
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 112
+	Hs
		1072259 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00
+	Mm
		193383 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		ELOC_MOUSE (1-112): 2.74e-68: 202: 100.00
+	Hs
		256854 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00
+	Dm
		1177326 Q7JVF1_DROME (26-218): 2.24e-49: 166: 18.04		Q7JWD6_DROME (1-112): 1.74e-67: 200: 90.35
+	Hs
		146630 SOCS2_HUMAN (3-221): 1.16e-46: 154: 28.31		ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00
+	Mm
		193363 SOCS2_MOUSE (3-221): 2.11e-46: 154: 28.31		ELOC_MOUSE (1-112): 2.74e-68: 202: 100.00
+	Hs
		1072315 CISH_HUMAN (13-221): 1.55e-45: 153: 30.62		ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00
+	Hs
		147523 SOCS6_HUMAN (15-220): 4.58e-39: 143: 22.64		ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00
+	Hs
		181868 SOCS1_HUMAN (19-221): 4.01e-37: 130: 25.98		ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00
+	Mm
		193346 SOCS1_MOUSE (19-221): 1.43e-36: 129: 25.49		ELOC_MOUSE (1-112): 2.74e-68: 202: 100.00