Protein: BIN1
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)

Gene: BIN1
Organism: Homo sapiens
Interactions: 137
UniProt ID: O00499

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002020 - protease binding
GO:0005543 - phospholipid binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

138461

AMPH
Amphiphysin

7

17

Small-scale

0.962

High

138533

BIN2
Bridging integrator 2

3

17

Small-scale

0.867

High

138411

BIN1
Myc box-dependent-interacting protein 1

3

17

Small-scale

0.835

High

138439

TAU
Microtubule-associated protein tau

5

13

Small-scale

0.728

High

138512

RIN3
Ras and Rab interactor 3

4

18

Small-scale

0.713

High

138431

MYC
Myc proto-oncogene protein

4

2

Small-scale

0.707

High

138497

DGUOK
Deoxyguanosine kinase, mitochondrial

3

1

High-throughput

0.667

High

138534

NUFP1
FMR1-interacting protein NUFIP1

3

1

High-throughput

0.667

High

138438

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

Small-scale

0.647

High

138483

SOS1
Son of sevenless homolog 1

3

9

Small-scale

0.641

High

138453

CLIP1
CAP-Gly domain-containing linker protein 1

2

3

Small-scale

0.640

High

138517

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

7

Small-scale

0.629

High

138458

CNDD3
Condensin-2 complex subunit D3

2

1

High-throughput

0.628

High

138425

SNX4
Sorting nexin-4

2

9

Small-scale

0.628

High

138479

E2F1
Transcription factor E2F1

2

1

Small-scale

0.624

High

138482

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

138485

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

138539

DLGP4
Disks large-associated protein 4

1

2

Small-scale

0.586

High

138437

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

0

High-throughput

0.585

High

138490

MTM1
Myotubularin

1

4

Small-scale

0.578

High

138511

REPS2
RalBP1-associated Eps domain-containing protein 2

1

19

Small-scale

0.578

High

138513

SYNE2
Nesprin-2

1

8

Small-scale

0.573

High

138434

F16P1
Fructose-1,6-bisphosphatase 1

1

0

Small-scale

0.561

High

138488

XRCC4
DNA repair protein XRCC4

1

0

Small-scale

0.561

High

138470

RAP1A
Ras-related protein Rap-1A

1

13

Small-scale

0.561

High

138455

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

1

High-throughput

0.541

High

138457

CUX1
Homeobox protein cut-like 1

1

4

High-throughput

0.541

High

138526

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

2

High-throughput

0.541

High

138535

DP13A
DCC-interacting protein 13-alpha

1

3

High-throughput

0.541

High

138417

IPO8
Importin-8

1

1

High-throughput

0.536

High

138428

KLF8
Krueppel-like factor 8

1

5

High-throughput

0.536

High

138454

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

138465

GPM6A
Neuronal membrane glycoprotein M6-a

1

1

High-throughput

0.536

High

138474

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

138528

SAR1A
Small COPII coat GTPase SAR1A

1

7

High-throughput

0.536

High

138531

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

2

High-throughput

0.536

High

138537

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.528

High

138481

DYN1
Dynamin-1

1

20

Small-scale

0.527

High

138427

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

138460

RFX3
Transcription factor RFX3

1

0

High-throughput

0.518

High

138468

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

0

High-throughput

0.518

High

138412

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.513

High

138509

CBARP
Voltage-dependent calcium channel beta subunit-associated regulatory protein

1

0

High-throughput

0.513

High

138493

FHL2
Four and a half LIM domains protein 2

1

6

Small-scale

0.508

High

133603

WASL
Actin nucleation-promoting factor WASL

1

20

Small-scale

0.501

High

138414

PLD2
Phospholipase D2

1

3

Small-scale

0.501

High

138429

AP2A1
AP-2 complex subunit alpha-1

1

20

Small-scale

0.501

High

138432

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

138475

ACTG
Actin, cytoplasmic 2

1

12

Small-scale

0.501

High

138477

ACTS
Actin, alpha skeletal muscle

1

10

Small-scale

0.501

High

138484

SOS2
Son of sevenless homolog 2

1

8

Small-scale

0.501

High

138486

PLD1
Phospholipase D1

1

3

Small-scale

0.501

High

138449

ITA6
Integrin alpha-6

1

3

Small-scale

0.481

High

138451

ITA3
Integrin alpha-3

1

3

Small-scale

0.481

High

138467

ITA1
Integrin alpha-1

1

3

Small-scale

0.481

High

138420

ROCK2
Rho-associated protein kinase 2

1

3

High-throughput

0.479

High

138424

AP2A2
AP-2 complex subunit alpha-2

1

20

Small-scale

0.479

High

138433

FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A

1

1

Small-scale

0.479

High

138441

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

2

Small-scale

0.479

High

138444

EF2
Elongation factor 2

1

1

Small-scale

0.479

High

138447

SYN1
Synapsin-1

1

13

Small-scale

0.479

High

138456

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

138459

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

138466

PLK1
Serine/threonine-protein kinase PLK1

1

3

Small-scale

0.479

High

138472

GRB2
Growth factor receptor-bound protein 2

1

18

High-throughput

0.479

High

138473

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

138478

CLH1
Clathrin heavy chain 1

1

5

Small-scale

0.479

High

138480

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

138489

GOGA4
Golgin subfamily A member 4

1

7

High-throughput

0.479

High

138495

BECN1
Beclin-1

1

2

Small-scale

0.479

High

138496

GOGB1
Golgin subfamily B member 1

1

7

High-throughput

0.479

High

138505

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

138523

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

138525

CHM4B
Charged multivesicular body protein 4b

1

2

Small-scale

0.479

High

138530

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

3

Small-scale

0.479

High

138532

HDAC6
Protein deacetylase HDAC6

1

2

Small-scale

0.479

High

138440

CLUS
Clusterin

1

0

Small-scale

0.458

High

138446

BGAL
Beta-galactosidase

1

0

Small-scale

0.458

High

138492

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

Small-scale

0.458

High

138504

CDC73
Parafibromin

1

0

Small-scale

0.458

High

138524

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

Small-scale

0.458

High

138415

SYNJ2
Synaptojanin-2

1

10

High-throughput

0.457

High

138418

PEPL
Periplakin

1

11

High-throughput

0.457

High

138421

KS6A5
Ribosomal protein S6 kinase alpha-5

1

4

High-throughput

0.457

High

138422

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

High-throughput

0.457

High

138423

PIAS2
E3 SUMO-protein ligase PIAS2

1

2

High-throughput

0.457

High

138435

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.457

High

138448

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

2

High-throughput

0.457

High

138450

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

9

High-throughput

0.457

High

138452

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.457

High

138462

RBP2
E3 SUMO-protein ligase RanBP2

1

2

High-throughput

0.457

High

138469

STXB1
Syntaxin-binding protein 1

1

4

High-throughput

0.457

High

138491

FHL1
Four and a half LIM domains protein 1

1

9

High-throughput

0.457

High

138494

GAS6
Growth arrest-specific protein 6

1

5

High-throughput

0.457

High

138506

RNB3L
Ran-binding protein 3-like

1

4

High-throughput

0.457

High

138514

RYR2
Ryanodine receptor 2

1

3

High-throughput

0.457

High

138515

RAB24
Ras-related protein Rab-24

1

7

High-throughput

0.457

High

138516

WBP2
WW domain-binding protein 2

1

5

High-throughput

0.457

High

138518

PWP2A
PWWP domain-containing protein 2A

1

4

High-throughput

0.457

High

138519

KS6C1
Ribosomal protein S6 kinase delta-1

1

4

High-throughput

0.457

High

138521

ZN251
Zinc finger protein 251

1

1

High-throughput

0.457

High

138527

RANB3
Ran-binding protein 3

1

4

High-throughput

0.457

High

138536

YETS2
YEATS domain-containing protein 2

1

4

High-throughput

0.457

High

138542

ZN451
E3 SUMO-protein ligase ZNF451

1

1

High-throughput

0.457

High

138543

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

High-throughput

0.457

High

138430

TTC4
Tetratricopeptide repeat protein 4

1

2

High-throughput

0.445

High

138436

MYZAP
Myocardial zonula adherens protein

1

4

High-throughput

0.445

High

138442

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.445

High

138443

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.445

High

138463

MMP14
Matrix metalloproteinase-14

1

2

High-throughput

0.445

High

138502

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.445

High

138508

DND1
Dead end protein homolog 1

1

2

High-throughput

0.445

High

138529

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

138413

PSA7
Proteasome subunit alpha type-7

1

0

High-throughput

0.438

High

138419

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.438

High

138445

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.438

High

138471

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.438

High

138476

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.438

High

138499

MCAF2
Activating transcription factor 7-interacting protein 2

1

0

High-throughput

0.438

High

138500

Z518A
Zinc finger protein 518A

1

0

High-throughput

0.438

High

138507

AGRA3
Adhesion G protein-coupled receptor A3

1

0

High-throughput

0.438

High

138520

TSNAX
Translin-associated protein X

1

0

High-throughput

0.438

High

138522

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.438

High

138538

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

1

0

High-throughput

0.438

High

138541

MTF2
Metal-response element-binding transcription factor 2

1

0

High-throughput

0.438

High

104813

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

138503

Q6NSK7
RIN3 protein

1

15

High-throughput

0.417

High

138464

DYN2
Dynamin-2

1

20

Small-scale

0.408

High

138426

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.407

High

138510

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.407

High

138501

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

3

0

High-throughput

0.334

High

65649

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

2

0

High-throughput

0.316

High

138416

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.238

Low

138498

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.238

Low

138487

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

138540

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025