Protein: TRIO
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)

Gene: TRIO
Organism: Homo sapiens
Interactions: 106
UniProt ID: O75962

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

299534

RAC1
Ras-related C3 botulinum toxin substrate 1

5

20

Small-scale

0.915

High

299535

RHOG
Rho-related GTP-binding protein RhoG

4

20

Small-scale

0.867

High

299549

MARE1
Microtubule-associated protein RP/EB family member 1

3

12

Small-scale

0.853

High

299592

ZN232
Zinc finger protein 232

2

5

High-throughput

0.811

High

299530

RHOA
Transforming protein RhoA

2

20

Small-scale

0.806

High

69750

ZN785
Zinc finger protein 785

3

3

High-throughput

0.765

High

299508

PTPRF
Receptor-type tyrosine-protein phosphatase F

2

2

Small-scale

0.754

High

299581

MYO10
Unconventional myosin-X

2

16

Small-scale

0.754

High

299551

CDC37
Hsp90 co-chaperone Cdc37

2

3

High-throughput

0.737

High

299526

NEK4
Serine/threonine-protein kinase Nek4

1

11

High-throughput

0.691

High

299553

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

3

High-throughput

0.691

High

299514

FLNA
Filamin-A

1

20

Small-scale

0.680

High

299498

TRIO
Triple functional domain protein

1

17

Small-scale

0.647

High

299529

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.647

High

299586

ITSN2
Intersectin-2

1

19

High-throughput

0.621

High

177751

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

17

Small-scale

0.618

High

299501

RASK
GTPase KRas

1

20

High-throughput

0.618

High

299504

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.618

High

299505

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

299507

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

299515

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

2

High-throughput

0.618

High

299518

EPHA2
Ephrin type-A receptor 2

1

17

High-throughput

0.618

High

299520

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.618

High

299521

CCNF
Cyclin-F

1

3

High-throughput

0.618

High

299524

GSK3A
Glycogen synthase kinase-3 alpha

1

17

High-throughput

0.618

High

299525

GSK3B
Glycogen synthase kinase-3 beta

1

19

High-throughput

0.618

High

299527

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.618

High

299531

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.618

High

299532

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

299541

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.618

High

299542

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.618

High

299543

SQSTM
Sequestosome-1

1

9

High-throughput

0.618

High

299546

ARHG7
Rho guanine nucleotide exchange factor 7

1

17

High-throughput

0.618

High

299547

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.618

High

299548

EPHA7
Ephrin type-A receptor 7

1

10

High-throughput

0.618

High

299550

NTRK3
NT-3 growth factor receptor

1

15

High-throughput

0.618

High

299557

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

299559

NAV3
Neuron navigator 3

1

20

Small-scale

0.618

High

299560

NAV2
Neuron navigator 2

1

20

Small-scale

0.618

High

299579

PRD16
Histone-lysine N-methyltransferase PRDM16

1

2

High-throughput

0.618

High

299588

ANFY1
Rabankyrin-5

1

20

High-throughput

0.618

High

299591

ALK
ALK tyrosine kinase receptor

1

16

High-throughput

0.618

High

299593

MARE3
Microtubule-associated protein RP/EB family member 3

1

12

High-throughput

0.618

High

299587

PALS2
Protein PALS2

1

8

High-throughput

0.595

High

299582

DISC1
Disrupted in schizophrenia 1 protein

2

11

High-throughput

0.590

High

299583

EXOC1
Exocyst complex component 1

2

3

High-throughput

0.590

High

299578

TOLIP
Toll-interacting protein

1

0

High-throughput

0.586

High

299595

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.586

High

299589

ZRAN1
Ubiquitin thioesterase ZRANB1

2

10

High-throughput

0.584

High

299573

CDC5L
Cell division cycle 5-like protein

2

8

High-throughput

0.576

High

299511

PIM1
Serine/threonine-protein kinase pim-1

1

11

High-throughput

0.575

High

299512

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.575

High

299570

AURKB
Aurora kinase B

1

2

High-throughput

0.575

High

299571

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

13

High-throughput

0.575

High

299562

NAV1
Neuron navigator 1

1

18

Small-scale

0.561

High

299556

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.553

High

299574

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.546

High

299523

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

11

High-throughput

0.541

High

299509

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.536

High

299563

LMO3
LIM domain only protein 3

1

8

High-throughput

0.536

High

104979

APRIO
Alternative prion protein

2

7

High-throughput

0.533

High

299545

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.518

High

299558

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.514

High

299500

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.489

High

299516

RBTN1
Rhombotin-1

1

8

High-throughput

0.489

High

298993

FLOT1
Flotillin-1

1

8

High-throughput

0.479

High

299506

PROF1
Profilin-1

1

4

High-throughput

0.479

High

299510

LAMP1
Lysosome-associated membrane glycoprotein 1

1

14

High-throughput

0.479

High

299513

CXA1
Gap junction alpha-1 protein

1

11

High-throughput

0.479

High

299519

HSP74
Heat shock 70 kDa protein 4

1

5

High-throughput

0.479

High

299522

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.479

High

299533

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

299536

DAB2
Disabled homolog 2

1

2

Small-scale

0.479

High

299538

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

299539

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

299540

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

High-throughput

0.479

High

299544

CUL3
Cullin-3

1

13

High-throughput

0.479

High

299564

PARD3
Partitioning defective 3 homolog

1

11

High-throughput

0.479

High

299566

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.479

High

299577

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

10

High-throughput

0.479

High

299580

CPAP
Centrosomal P4.1-associated protein

1

20

High-throughput

0.479

High

299590

XPO7
Exportin-7

1

0

High-throughput

0.458

High

142256

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.445

High

299503

C1QC
Complement C1q subcomponent subunit C

1

2

High-throughput

0.445

High

299554

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.445

High

299596

SRPRB
Signal recognition particle receptor subunit beta

1

5

High-throughput

0.445

High

299499

ZFPL1
Zinc finger protein-like 1

1

4

High-throughput

0.437

High

299517

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

299537

CAV1
Caveolin-1

1

10

High-throughput

0.437

High

299552

OCLN
Occludin

1

6

High-throughput

0.437

High

299555

RL22L
Ribosomal protein eL22-like

1

1

High-throughput

0.437

High

299561

NIN
Ninein

1

20

High-throughput

0.437

High

299565

ESR2
Estrogen receptor beta

1

14

High-throughput

0.437

High

299567

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

299572

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

299594

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.426

High

299528

DSCR9
Down syndrome critical region protein 9

1

4

High-throughput

0.417

High

299568

EMID1
EMI domain-containing protein 1

1

2

High-throughput

0.407

High

299569

HDA11
Histone deacetylase 11

1

14

High-throughput

0.407

High

299575

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

2

High-throughput

0.407

High

299584

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

2

0

High-throughput

0.298

High

299502

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.279

Low

299585

ADA2
Adenosine deaminase 2

1

0

High-throughput

0.279

Low

63737

KRBA1
Protein KRBA1

1

0

High-throughput

0.232

Low

299576

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025